赵德鹏

简单介绍

赵德鹏，博士，中山大学教授，博导。2017入选国家重大人才项目并进入bm11222宝马娱乐网站工作。主要研究领域为分子马达设计合成、合成有机化学、多肽及小分子药物化学等。至今在Nature， Nature Chemistry，Chem，Nature Communications, J. Am. Chem. Soc.，Angew. Chem. Int. Ed., Chemical Science等杂志发表论文30余篇，文章累计被引用1500余次。目前主持国家海外高层次青年人才启动基金，中山大学“百人计划”启动基金，国家自然科学基金面上项目，国家自然科学基金青年科学基金等多个基金项目，并以第一核心成员参与2017年“珠江人才计划”创新创业团队青年英才项目。2019年入选广东省珠江人才计划青年拔尖人才项目。

ORCID ID：https://orcid.org/0000-0002-3058-9958

研究方向

1. 化学能驱动分子机器的设计合成。
2. 多肽药物与手性药物的研发。
3. 光控分子开关以及超分子催化体系的设计。

教育经历

2007.09 - 2012.07 兰州大学，博士

2003.09 - 2007.07 兰州大学，学士

工作经历

2017.05 - 至今   bm11222宝马娱乐网站，教授

2012.09 - 2017.02 荷兰格罗宁根大学，博士后，合作导师：Ben L. Feringa (2016诺贝尔化学奖得主)

招生招聘信息

1)   实验室开始接收2023年博士申请，欢迎联系。

2）实验室长期招聘有机合成方向博士后。

论著专利

近期工作

7) Geshuyi Chen, Zhe Chang, Pei Yuan, Si Wang, Yongxiu Yang*, Xiaolei Liang* and Depeng Zhao*, Late-stage functionalization of 5-nitrofurans derivatives and their antibacterial activities, RSC Adv., 2023,13, 3204-3209

6) Zhanyong Tang, Ke Mo, Xiaoqiang Ma, Jialin Huang, Depeng Zhao*, para-Selective Radical Trifluoromethylation of Benzamide Derivatives via Iminium Intermediates, Angew. Chem. Int. Ed., 2022, DOI: 10.1002/anie.202208089

5) Hong Wang, Zhe Chang, Guo-di Cai, Ping Yang, Jiang-he Chen, Shan-shu Yang, Yin-feng Guo, Ming-yu Wang, Xue-hua Zheng, Jin-ping Lei, Pei-qing Liu, De-peng Zhao* & Jun-jian Wang*,  The novel indomethacin derivative CZ-212-3 exerts antitumor effects on castration-resistant prostate cancer by degrading androgen receptor and its variants. Acta Pharmacol Sin (2021). https://doi.org/10.1038/s41401-021-00738-w

4) Zhe Chang, Jialin Huang, Si Wang, Geshuyi Chen, Heng Zhao, Rui Wang* & Depeng Zhao*, Copper catalyzed late-stage C(sp3)-H functionalization of nitrogen heterocycles. Nat. Commun. 12, 4342 (2021). https://doi.org/10.1038/s41467-021-24671-y

3） Yu Zhang, Zhe Chang, Heng Zhao, Stefano Crespi, Ben L. Feringa*, and Depeng Zhao*，A Chemically Driven Rotary Molecular Motor Based on Reversible Lactone Formation with Perfect Unidirectionality. Chem, 2020, 6, 2420-2429. https://doi.org/10.1016/j.chempr.2020.07.025

2）Ajmal Khan*， Heng Zhao，Meina Zhang， Shahid Khan，Depeng Zhao*，Regio- and Enantioselective Synthesis of Sulfone-Bearing Quaternary Carbon Stereocenters by Pd-Catalyzed Allylic Substitution. Angew. Chem. Int. Ed. 2020, 59,1340 –1345.  https://doi.org/10.1002/anie.201910378

1）Zhe Chang，Tong Ma，Yu Zhang，Zheng Dong，Heng Zhao，Depeng Zhao* Synthesis of Functionalized Indoles via Palladium-Catalyzed Cyclization of N-(2-allylphenyl) Benzamide: A Method for Synthesis of Indomethacin Precursor.Molecules 2020, 25(5), 1233. https://doi.org/10.3390/molecules25051233

前期工作

1) Depeng Zhao, Thomas van Leeuwen, Jinling Cheng, Ben L. Feringa*, Dynamic Control of Chirality and Self-Assembly of Double–Stranded Helicates with Light, Nature Chemistry, 2017, 9, 250-256.

2) Depeng Zhao, Thomas M. Neubauer, and Ben L. Feringa*, Dynamic Control of Chirality in Phosphine Ligands for Enantioselective Catalysis, Nature Communications, 2015, 6652.

3) Depeng Zhao, Linqing Wang, Dongxu Yang, Yixin Zhang and Rui Wang*, Highly Diastereo- and Enantioselective Synthesis of α-Alkyl Norstatine Derivatives: Catalytic Asymmetric Mannich Reactions of 5H-Oxazol-4-ones, Angew. Chem. Int. Ed., 2012, 51, 7523 –7527. 

4) Depeng Zhao, Dongxu Yang, Yijie Wang, Yuan Wang, Linqing Wang, Lijuan Mao and Rui Wang*, Enantioselective Mannich reaction of a highly reactive Horner–Wadsworth–Emmons reagent with imines catalyzed by a bifunctional thiourea, Chem. Sci., 2011, 2, 1918-1921. 

5) Depeng Zhao, Martín Fañanás-Mastral, Mu-Chieh Chang, Edwin Otten, and Ben L. Feringa*, Asymmetric Synthesis of N,O-Heterocycles Derivatives via Iridium-Catalysed Intramolecular Enantioselective Allylic Substitution with Amides, Chem. Sci., 2014, 5,4216-4220.

6) Depeng Zhao, and Rui Wang*, Recent Developments in Metal Catalyzed Asymmetric Addition of Phosphorus Nucleophiles, Chem. Soc. Rev., 2012, 41, 2095-2108.

7) Depeng Zhao, Lijuan Mao, Linqing Wang, Dongxu Yang, and Rui Wang*, Catalytic Asymmetric Construction of Tetrasubstituted Carbon Stereocenters by Conjugate Addition of Dialkyl Phosphine Oxides to β,β-Disubstituted α,β-Unsaturated Carbonyl Compounds, Chem. Commun., 2012, 48, 889–891. 

8) Depeng Zhao, Lijuan Mao, Yuan Wang, Dongxu Yang, Quanliang Zhang, and Rui Wang*, Catalytic Asymmetric Hydrophosphinylation of α,β-Unsaturated N-Acylpyrroles: Application of Dialkyl Phosphine Oxides in Enantioselective Synthesis of Chiral Phosphine Oxides or Phosphines, Org. Lett. 2010, 12, 1880-1882. 

9) Depeng Zhao, Lijuan Mao, Dongxu Yang, and Rui Wang*, Zinc-Mediated Asymmetric Additions of Dialkylphosphine Oxides to α,β-Unsaturated Ketones and N-Sulfinylimines, J. Org. Chem., 2010, 75, 6756. 

10) Depeng Zhao, Ye Yuan, Albert S. C. Chan, and Rui Wang*, Highly Enantioselective 1,4-Addition of Diethyl Phosphite to Enones Using a Dinuclear Zn Catalyst, Chem. Eur. J., 2009, 15, 2738-2741. 

11) Depeng Zhao, Yuan Wang, Lijuan Mao, and Rui Wang*, Highly Enantioselective Conjugate Additions of Phosphites to α,β-Unsaturated N-Acylpyrroles and Imines: A Practical Approach to Enantiomerically Enriched Amino Phosphonates. Chem. Eur. J., 2009, 15, 10983-10987. 

12) Depeng Zhao, Linqing Wang, Dongxu Yang, Yixin Zhang and Rui Wang*, Highly Efficient Asymmetric Michael Addition of Diaryl Phosphine Oxides to α,β-Unsaturated N-Acylated Oxazolidin-2-ones, Chem. Asian J., 2012,7, 881-883. 

13) Thomas M. Neubauer , Thomas van Leeuwen, Depeng Zhao , Anouk S. Lubbe , Jos C. M. Kistemaker , and Ben L. Feringa*, Asymmetric Synthesis of First Generation Molecular Motors, Org. Lett., 2014, 16 , 4220–4223.

14) Thomas van Leeuwen, G. Henrieke Heideman, Depeng Zhao, Sander J. Wezenberg * and Ben L. Feringa *, In situ control of polymer helicity with a non-covalently bound photoresponsive molecular motor dopant, Chem. Commun., 2017, 53, 6393-6396. 

15) Dongxu Yang, Linqing Wang, Fengxia Han, Depeng Zhao, Bangzhi Zhang, Rui Wang*, Direct Site-Specific and Highly Enantioselective γ-Functionalization of Linear α,β-Unsaturated Ketones: Bifunctional Catalytic Strategy, Angew. Chem. Int. Ed., 2013, 52, 6739–6742.

16) Dongxu Yang, Depeng Zhao, Lijuan Mao, Linqing Wang, and Rui Wang*, Copper/DIPEA-Catalyzed, Aldehyde-Induced Tandem Decarboxylation-Coupling of Natural alpha-Amino Acids and Phosphites or Secondary Phosphine Oxides, J. Org. Chem., 2011, 76 , 6426.

17) Dongxu Yang, Linqing Wang, Depeng Zhao, Fengxia Han, Bangzhi Zhang, Rui Wang*, Development of Metal/Organo Catalytic Systems for Direct Vinylogous Michael Reactions to Build Chiral γ,γ-Disubstituted Butenolides. Chem. Eur. J., 2013, 19, 4691–4694.

18) Liang Hong, Wangsheng Sun, Chunxia Liu, Depeng Zhao and Rui Wang*, Chem. Commun., 2010, 46, 2856.

19) Wenjin Yan, Dong Wang, Jingchao Feng, Peng Li, Depeng Zhao, Rui Wang*, Synthesis of N-Alkoxycarbonyl Ketimines Derived from Isatins and Their Application in Enantioselective Synthesis of 3-Aminooxindoles, Org. Lett., 2012, 2512–2515.

20) Xin Liu, Yuan Wang, Yanhong Xing, Jing Yu, Hong Ji, Ming Kai,Zilong Wang, Dan Wang, Yixin Zhang, Depeng Zhao, Rui Wang*, Design, Synthesis and Pharmacological Characterization of Novel Endomorphin-1 Analogues as Extremely Potent μ Opioid Agonists, J. Med. Chem., 2013, 56, 3102–3114.

21) Yuan Wang, Yanhong Xing, Xin Liu, Hong Ji, Ming Kai, Zongyao Chen, Jing Yu, Depeng Zhao, Hui Ren, Rui Wang*, A new class of highly potent and selective endomorphin-1 analogues containing α-methylene-β-aminopropanoic acids (map), J. Med. Chem., 2012, 55, 6224–6236.

22) Dongxu Yang, Linqing Wang, Fengxia Han, Depeng Zhao and Rui Wang*, Design of a Combinational Magnesium Catalyst for the Stereocontrolled Cross Reaction of Enones, Chem. Eur. J., 2014, 20, 8584 – 8588.

23) Bangzhi Zhang, Fengxia Han, Linqing Wang, Dan Li, Dongxu Yang, Xiaoli Yang, Junxian Yang, Xiaofang Li, Depeng Zhao, and Rui Wang*, Catalytic Asymmetric Michael Reaction of 5H-Oxazol-4-Ones with α,β-Unsaturated AcylImidazoles, Chem. Eur. J., 2015, 21, 17234 – 17238.

24) Dongxu Yang, Dan Li, Linqing Wang, Depeng Zhao, and Rui Wang*, Development and Application of α-Heteroatom Ketones in Asymmetric Michael Reaction with β- Trans –Nitroalkenes, J. Org. Chem., 2015, 80, 4336–4348.

25) Dongxu Yang, Linqing Wang, Fengxia Han, Dan Li, Depeng Zhao, and Rui Wang* Intermolecular Enantioselective Dearomatization Reaction of β-Naphthol Using meso -Aziridine: A Bifunctional In Situ Generated Magnesium Catalyst, Angew. Chem. Int. Ed., 2015, 54, 2185 –2189.

26) Dongxu Yang, Linqing Wang, Dan Li, Fengxia Han, Depeng Zhao, and Rui Wang*, Asymmetric anti-Selective Michael Reaction of Imidazole-Modified Ketones with trans-β-Nitroalkenes. Chem. Eur. J., 2015, 21, 1458 – 1462.

27) Dongxu Yang, Linqing Wang, Fengxia Han, Dan Li, Depeng Zhao, Yiming Cao, Yunxia Ma, Weidong Kong, Quantao Sun, and Rui Wang* Highly Enantioselective Ring-Opening Reactions of Aziridines with Indole and Its Application in the Building of C3-Halogenated Pyrroloindolines. Chem. Eur. J., 2014, 20, 16478 – 16483.

28) Linqing Wang, Dongxu Yang,Fengxia Han,Dan Li, Depeng Zhao, and Rui Wang*, Catalytic Asymmetric Construction of Pyrroloindolines via an in situ Generated Magnesium Catalyst, Org. Lett., 2015, 17, 176−179.

获奖情况

1) 教育部自然科学奖一等奖2014（排名第四），

2）中国药学会科学技术奖一等奖2013（排名第六）

3）珠江人才计划青年拔尖项目