1

张元庆

教授

研究领域：高通量微流控芯片用于液体活检和单细胞分析；框架核酸材料在分析方法学中的应用；多功能纳米材料用于癌症的诊断和治疗

办公电话： bm11222宝马娱乐网站323室

联系邮箱： zhangyq65@mail.sysu.edu.cn

联系方式

电子邮箱：zhangyq65@mail.sysu.edu.cn

办公地址：bm11222宝马娱乐网站323室

简单介绍

张元庆教授，博导，长期从事微流控芯片和框架核酸材料在癌症转移、液体活检等领域的基础和应用研究。其科研成果以通讯作者身份在Angewandte Chemie International Edition、Journal  of  the  American  Chemical  Society、Nano  Letters和Advanced Science等期刊上发表多篇高水平论文。

研究方向

高通量微流控芯片用于液体活检和单细胞分析；框架核酸材料在分析方法学中的应用；多功能纳米材料用于癌症的诊断和治疗。

教育经历

2006.09 - 2011.06 中国科学院上海应用物理所 博士

2000.09 - 2004.07 中国科学技术大学 学士

工作经历

2015.10 - 至今   bm11222宝马娱乐网站教授

2011.07 - 2015.10 美国康奈尔大学医学院HMRI博士后

教学情况

《分析化学》《基础化学》《大学化学实验二》等 本科生课程

《药物仪器分析》 研究生课程

社会/学术任职

《药学学报》青年编委 第二届

广东省药学会生物医药分析专业委员会副主任委员

中国微米纳米技术学会微纳流控技术分会理事会理事

科研项目

广东省自然科学基金 面上项目 2024-2026

国家自然科学基金 面上项目 2021-2024；

广东省自然科学基金 杰出青年项目 2017-2021;

国家自然科学基金 青年项目 2017-2019；

中山大学“百人计划二期”启动项目 2015-2017；

中山大学青年教师重点培育计划 2016-2017；

中山大学重大项目培育和新兴、交叉学科资助计划 2017-2018;

其他与企业合作的横向项目等。

论著专利

代表性论文：

  1. Dongdong Zhu, Xiaocao Ma, Jingguo Wang, Tiantian Chen, Jiahui Yang, Yan Liu, Zhun Lin, Minhao Wu*, Tony Y. Hu*,  Yuanqing Zhang*. A Sequential Release Micro-nano System for Colitis Therapy via Gut Microbiota and Immune Regulation. Angewandte Chemie International Edition2025, DOI：10.1002/anie.202424409
  2. Jingguo Wang, Siping Liang, Dongdong Zhu, Xiaocao Ma, Qin Peng, Guanzhao Wang, Yuting Wang, Tiantian Chen, Minhao Wu*, Tony Y Hu*, Yuanqing Zhang*. Valence-Change MnO2-coated Arsenene Nanosheets as Pin1 Inhibitor for Hepatocellular Carcinoma Treatment. Journal of the American Chemical Society;2024; 146, 21568−21582
  3. Miao Mao, Zhun Lin,  Liang Chen, Zhengyu Zou, Jie Zhang, Quanhao Dou, Jiacheng Wu, Jinglin Chen, Minhao Wu, Li Niu,  Chunhai Fan, Yuanqing Zhang*. Modular DNA-Origami-Based Nanoarrays Enhanced Cell Binding-Affinity through “Lock-and-Key” Interaction. Journal of the American Chemical Society;2023;  145, 9, 5447–5455
  4. Jiacheng Wu, Zhun Lin, Zhengyu Zou, Siping Liang, Minhao Wu*, Tony Y Hu*, Yuanqing Zhang*. Identifying the Phenotypes of Tumor-Derived Extracellular Vesicles using Size-coded Affinity Microbeads. Journal of the American Chemical Society;2022; 144, 51, 23483–23491
  5. Zhun Lin,Jie Zhang,Zhengyu Zou,Gen Lu,Minhao Wu*,Li Niu*,Yuanqing Zhang*. A Dual-Encoded Bead-Based Immunoassay with Tunable Detection Range for COVID-19 Serum Evaluation. Angewandte Chemie International Edition 2022, 61(37), e202203706 

其他论文：

  1. Peng Zhang, Jinxiu Han, Xue Kong, Shaojun Liu, Yuqing Chen, Juan Li, Yuanqing Zhang*, Chuanxin Wang*, Lutao Du*. Biomimetic Synthesis of Nanomachine Inspired from Neutrophil Extracellular Traps for Multi-modal Antibacterial Application. ACS Nano.2025. ASAP
  2. Zhun Lin, Siping Liang, Zhe Pu, Zhengyu Zou, Luxuan He, Christopher J. Lyon, Yuanqing Zhang*,Tony Y. Hu*, Minhao Wu*. Phenotypic plasticity and secretory heterogeneity in subpopulations derived from single cancer cell. Acta Pharmaceutica Sinica B. 2025. ASAP
  3. Yuyuan Zhang, Xiaojie Qin, Zhanyu Xu, Weifeng Liu, Hao Lu, Yu Yang, Jie Yang, Xinchun Li, Yuanqing Zhang*, Fan Yang*. Electric Field-Resistant Bubble-Enhanced Wash-Free Profiling of Extracellular Vesicle Surface Markers.  ACS Nano.2025. ASAP
  4. Jie Zhang, Jiacheng Wu, Guanzhao Wang, Luxuan He, Ziwei Zheng, Minhao Wu, Yuanqing Zhang*. Extracellular Vesicles: Techniques and Biomedical Applications Related to Single Vesicle Analysis. ACS Nano.2023 Sep 26;17(18):17668-17698.
  5. Jie Zhang, Liwen Wei, Xiaocao Ma, Jingguo Wang, Siping Liang, Kang Chen, Minhao Wu, Li Niu, Yuanqing Zhang*. pH-sensitive tumor-tropism hybrid membrane-coated nanoparticles for reprogramming the tumor microenvironment and boosting the antitumor immunity. Acta Biomater .2023 166:470-484.
  6. Zhengyu Zou, Zhun Lin, Chenglin Wu, Jizhou Tan, Jie Zhang, Yanwen Peng, Kunsong Zhang, Jiaping Li, Minhao Wu*, Yuanqing Zhang*. Micro-Engineered Organoid-on-a-Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients. Advanced Science2023 Sep;10(27):e2302640. doi: 10.1002/advs.202302640.
  7. Zhun Lin, Zhengyu Zou, Zhe Pu, Minhao Wu*,Yuanqing Zhang*.  Application of Microfluidic Technologies on COVID-19 Diagnosis and Drug Discovery.Acta Pharmaceutica Sinica B. 2023; 13(7):2877-2896. 
  8. Jizhou Tan, Ting Liu, Wenzhe Fan, Jialiang Wei, Bowen Zhu, Yafang Liu, Lingwei Liu, Xiaokai Zhang, Songling Chen, Haibiao Linc, Yuanqing Zhang*, Jiaping Li*. Anti-PD-L1 antibody enhances curative effect of cryoablation via antibody-dependent cell-mediated cytotoxicity mediating PD-L1highCD11b+ cells elimination in hepatocellular carcinoma. Acta Pharmaceutica Sinica B. 2023; 13(2), 632-647
  9. Liang Chen, Shihua Luo, Zhilei Ge, Chunhai Fan, Yang Yang*, Qian Li*,  Yuanqing Zhang*. Unbiased Enrichment of Circulating Tumor Cells via DNAzyme Catalyzed Proximal Protein Biotinylation. Nano Letters.2022, 22, 4, 1618–1625.
  10. Lingwei Liu, Jialang Zhuang, Jizhou Tan, Ting Liu, Wenzhe Fan, Yuanqing Zhang*, and Jiaping Li*. Doxorubicin-Loaded UiO-66/Bi2S3 Nanocomposite-Enhanced Synergistic Transarterial Chemoembolization and Photothermal Therapy against Hepatocellular Carcinoma. ACS Applied Materials & Interfaces. 2022, 14, 6, 7579–7591.
  11. Yan Liu, Zhun Lin, Ziwei Zheng, Yuanqing Zhang*, Lingling Shui*.  Accurate Isolation of Circulating Tumor Cells via a Heterovalent DNA Framework Recognition Element Functionalized Microfluidic Chip. ACS Sensors. 2022, 7, 2, 666–673.
  12. Siping Liang,  Jiaying Li, Zhengyu Zou, Miao Mao, Siqi Ming, Fan Lin, Ziyan Zhang, Can Cao, Jinyu Zhou, Yuanqing Zhang*, Jiaping Li *, Minhao Wu*. Tetrahedral DNA Nanostructures Synergize with MnO2 to Enhance Antitumor Immunity via Promoting STING Activation and M1 Polarization. Acta Pharmaceutica Sinica B. 2022; 12(5), 2494-2505.
  13. Liang Chen, Jie Zhang, Zhun Lin, Ziyan Zhang, Miao Mao, Jiacheng Wu, Qian Li, Yuanqing Zhang*, Chunhai Fan*. Pharmaceutical applications of framework nucleic acids. Acta Pharmaceutica Sinica B. 2022; 12(1), 76-91. Invited Review
  14. Ziyan Zhang, Qiaojuan Liu, Jizhou Tan, Xiaoxia Zhan, Ting Liu, Yuting Wang, Gen Lu*, Minhao Wu*, Yuanqing Zhang*. Coating with flexible DNA network enhanced T-cell activation and tumor killing for adoptive cell therapy. Acta Pharmaceutica Sinica B. 2021;11, 1965-1977.(Cover story)
  15. Fan Lin, Yong Shao, Yingjie Wu, Yuanqing Zhang*. NIR light-Propelled Janus-Based Nanoplatform for Cytosolic-Fueled MicroRNA Imaging. ACS  Appl. Mater. Interfaces. 2021; 13(3), 3713-3721.
  16. Weiwei Qin, Liang Chen, Zhiru Wang, Qian Li*, Chunhai Fan, Minhao Wu, Yuanqing Zhang*. Bioinspired DNA Nanointerface with Anisotropic Aptamers for Accurate Capture of Circulating Tumor Cells. Advanced Science. 2020;DOI: 10.1002/advs.202000647.
  17. Liang Chen, Siping Liang, Yu Chen, Minhao Wu*, Yuanqing Zhang*. Destructing the Plasma Membrane with Activatable Vesicular DNA Nanopores. ACS  Appl. Mater. Interfaces. 2020;12, 1: 96-105.
  18. Jialang Zhuang, Jizhou Tan, Chenglin Wu, Jie Zhang, Ting Liu, Chunhai Fan, Jiaping Li*, Yuanqing Zhang*. Extracellular vesicles engineered with valency-controlled DNA nanostructures deliver CRISPR/Cas9 system for gene therapy. Nucleic Acids Research, 2020, 48(16)，8870-8882.
  19. Yubing Liu, Dabin Chen, Weiqiong Zhang, Yuanqing Zhang*. Mobile DNA tetrahedron on ultra-low adsorption lipid membrane for directional control of cell sensing. Sensors and Actuators B: Chemical.2020; 307, 127570.
  20. Jialang Zhuang, Jie Zhang, Minhao Wu, Yuanqing Zhang* A Dynamic 3D Tumor Spheroid Chip Enables More Accurate Nanomedicine Uptake Evaluation. Advanced Science. 2019; DOI: 10.1002/advs.201901462
  21. Zhiru Wang, Weiwei Qin*, Jialang Zhuang, Minhao Wu, Qian Li, Chunhai Fan*, Yuanqing Zhang*. Virus-Mimicking Cell Capture Using Heterovalency Magnetic DNA Nanoclaws. ACS  Appl. Mater. Interfaces. 2019; 11: 12244–12252.
  22. Maosheng Xu, Kunsong Zhang, Yubing Liu, Jie Wang, Ke Wang*, Yuanqing Zhang*. Multifunctional MoS2 nanosheets with Au NPs grown in situ for synergistic chemo-photothermal therapy. Colloids and Surfaces B: Biointerfaces2019; 184, 110510.
  23. Ke Wang, Xi Liu, Jialang Zhuang, Yubing Liu, Maosheng Xu, Dong Xie, Junjia Chen*, Xiaoyong Zhang, Yen Wei, Yuanqing Zhang*. Small fluorescent albumin nanoparticles for targeted photothermal therapy via albumin-Binding protein pathways. Colloids and Surfaces B: Biointerfaces2019; 181,696-704.
  24. Jialang Zhuang, Yongjian Wu, Liang Chen, Siping Liang, Minhao Wu, Ledu Zhou, Chunhai Fan, Yuanqing Zhang*. Single‐Cell Mobility Analysis of Metastatic Breast Cancer Cells. Advanced Science. 2018；DOI: 10.1002/advs.201801158.
  25. Dabin Chen, Duanping Sun, Zhiru Wang, Weiwei Qin, Liang Chen, Ledu Zhou, Yuanqing Zhang*. A DNA nanostructured aptasensor for the sensitive electrochemical detection of HepG2 cells based on multibranched hybridization chain reaction amplification strategy.  Biosensors and Bioelectronics.2018; 117:416-421.
  26. Zijun Zhao, Yu Chen, Ngiambudulu M. Francisco, Yuanqing Zhang*, Minhao Wu*. The application of CAR-T cell therapy in hematological malignancies: Advantages and challenges. Acta Pharmaceutica Sinica B. 2018; 8; 539-551.
  27. Duanping Sun, Jing Lu, Dabin Chen, Yunfei Jiang, Zhiru Wang, Weiwei Qin, Yanyan Yu, Zuanguang Chen,Yuanqing Zhang*. Label-free electrochemical detection of HepG2 tumor cells with a self-assembled DNA nanostructure-based aptasensor. Sensors and Actuators B: Chemical.2018; 268:359-367.
  28. Yunfei Jiang, Duanping Sun, Zhixian Liang, Liang Chen, Yuanqing Zhang*, Zuanguang Chen*. Label-free and competitive aptamer cytosensor based on layer-by-layer assembly of DNA-platinum nanoparticles for ultrasensitive determination of tumor cells. Sensors and Actuators B: Chemical. 2018; 262:35-43.
  29. Ke Wang, Jialang Zhuang, Yubing Liu, Maosheng Xu, Jingyuan Zhuang, Zuanguang Chen, Yen Wei, Yuanqing Zhang*. PEGylated chitosan nanoparticles with embedded bismuth sulfide for dual-wavelength fluorescent imaging and photothermal therapy. Carbohydrate Polymers. 2018; 184:445-452.
  30. Ke Wang, Jialang Zhuang, Liang Chen, Dazhuang Xu, Xiaoyong Zhang, Zuanguang Chen, Yen Wei, Yuanqing Zhang*. One-pot synthesis of AIE based bismuth sulfide nanotheranostics for fluorescence imaging and photothermal therapy. Colloids and Surfaces B: Biointerfaces2017; 160(1): 297-304.
  31. Duanping Sun, Zuanguang Chen, Minhao Wu*, Yuanqing Zhang*. Nanomaterial-based Microfluidic Chips for the Capture and Detection of Circulating Tumor Cells. Nanotheranostics2017; 1(4):389-402. doi:10.7150/ntno.21268. 
  32. Duanping Sun, Jing Lu, Xiangyan Wang, Yuanqing Zhang*, Zuanguang Chen*. Voltammetric aptamer based detection of HepG2 tumor cells by using an indium tin oxide electrode array and multifunctional nanoprobes. Microchimica Acta 2017; 84(9): 3487–3496.
  33. Ying Zhu, Jichao Zhang, Aiguo Li, Yuanqing Zhang*, Chunhai Fan*. Synchrotron-based X-ray microscopy for sub-100nm resolution cell imaging. Current Opinion in Chemical Biology. 2017; 15, 11-16.
  34. Weiwei Qin, Guan Huang, Zuanguang Chen*, Yuanqing Zhang*. Nanomaterials in Targeting Cancer Stem Cells for Cancer Therapy. Frontiers in Pharmacology. 2017; 18, 1-8.

2016年之前

  1. Yuanqing Zhang, Minhao Wu, Xin Han, Ping Wang, Lidong Qin*. High‐Throughput, Label-Free Isolation of Cancer Stem Cells on the Basis of Cell Adhesion Capacity. Angewandte Chemie International Edition 2015; 127，10838-10842.
  2. Yuanqing Zhang, Ledu Zhou, Lidong Qin*. Utilizing a High-Throughput Microfluidic Platform to Study Hypoxia-Driven Mesenchymal-Mode Cell Migration. Integrative Biology 2015； 7，672-680.
  3. Yuanqing Zhang, Ledu Zhou, Lidong Qin*. High-Throughput 3D Cell Invasion Chip Enables Accurate Cancer Metastatic Assays. Journal of the American Chemical Society 2014; 136， 15257-15262.
  4. Yuanqing Zhang, Weijia Zhang, Lidong Qin*. Mesenchymal-Mode Migration Assay and Antimetastatic Drug Screening with High-Throughput Microfluidic Channel Networks. Angewandte Chemie International Edition 2014; 53，2344-2348.
  5. Yuanqing Zhang, Xiaoping Xu, Lu Wang, Jun Lin, Ying Zhu, Zhi Guo, Yanhong Sun*, Hua Wang, Yun Zhao, Renzhong Tai, Xiaohan Yu, Chunhai Fan, Qing Huang*. Dendrimer-folate-copper conjugates as bioprobes for synchrotron X-ray fluorescence imaging. Chemical Communications 2013; 49，10388-10390.
  6. Yuanqing Zhang, Yanhong Sun, XiaopingXu, Xuezhu Zhang, Hua Zhu, Liliang Huang, Yujin Qi, Yu-Mei Shen*. Synthesis, biodistribution, and microsingle photon emission computed tomography (SPECT) imaging study of technetium-99m labeled PEGylated dendrimer poly(amidoamine) (PAMAM)-folic acid conjugates. Journal of Medicinal Chemistry. 2010; 53, 3262-72.

其他

本课题组常年欢迎特聘研究员系列、博士后、研究助理和研究生等优秀科研人员加入。