张学景

简单介绍

张学景，女，副教授。中山大学“百人计划”人才，硕士生导师

本课题组2025年有专硕招生计划，欢迎联系。

教育经历

2006年9月-2009年6月　中山大学　　　　　有机化学　博士（陈新滋院士、鄢明教授）
2001年9月-2004年7月　中科院广州化学所　有机化学　硕士（邹永研究员）
1997年9月-2001年7月　聊城大学　　　　　化学教育　本科

工作经历

2011年12月至今　bm11222宝马娱乐网站　　 副教授
2018年至2019年   美国Scripps研究所  访问学者 （Prof. Phil Baran）
2009年至2011年　日本京都大学　　　 博士后 (Prof. Tamio Hayashi)
2004年至2006年　中科院广州化学所　 助理研究员

科研项目

中山大学科研启动基金,  40万, 2012.01-2013.12（主持）

国家自然科学基金青年项目,25万,2013.01-2015.12（主持）

广州市南沙区科技计划项目, 20万,2016.10-2018.9(中大主持）

高校基本科研业务费青年教师培育项目，15万，2020.1-2022.12（主持）

广东省基础与应用基础项目，10万，2021.01-2023.12 （主持）

广东省基础与应用基础项目，10万，2022.01-2024.12 （主持）

横向项目3万 2017.10-2018.12（主持）

横向项目26万 2020.01-2021.12（主持）

论著专利

1. Wen-jie Xiao, Cheng-xin Li, Jing-yi Lv, Shan Xu, Wen-xia Shi, Xiao-can Su, Jia-ying Xue, Bao-qin Huang, Yong Zou, Ming Yan, Xue-jing Zhang* Molecular Editing of Pyrroles to Benzenes/Naphthalenes by N2O Deletion Angew. Chem. Int. Ed. 2024, doi/10.1002/anie.202411166
2. Yue Zhang#, Jia-ying Xue#, Xiao-can Su, Wen-jie Xiao, Jing-yi Lv, Wen-xia Shi, Yong Zou, Ming Yan*, Xue-jing Zhang* Skeletal editing of benzene motif: photo-promoted transannulation for synthesis of DNA-encoded seven-membered rings Org. Lett. 2024, 26, 2212-2217.
3. Xiao-can Su, Wen-xia Shi, Yue Zhang, Wen-jie Xiao, Jia-ying Xue, Xin-hai Zhu, Ming Yan, Xue-jing Zhang* Anhydrous Carbene Insertion Reactions: A Synthetic Platform for DNA-Encoded Library Adv. Synth. Catal. 2024, 366, 285-290.
4. Yue Zhang, Shengdi Xia, Wen-xia Shi, Bi-zhen Lin, Xiao-can Su, Weiwei Lu, Xinyuan Wu, Xuan Wang, Xiaojie Lu, Ming Yan, and Xue-jing Zhang* Radical C–H Sulfonation of Arenes: Its Applications on Bioactive and DNA-Encoded Molecules Org. Lett. 2022, 24, 7961-7966.
5. Dong-yu Zhu, Yuan Chen, Xue-jing Zhang* and Ming Yan* Regioselective conjugate addition of isoxazol-5-ones to ethenesulfonyl fluoride Org. Biomol. Chem., 2022, 20, 4714–4718.
6. Jie Chen, Yue Zhang, Dong-yu Zhu, Xue-jing Zhang,* Ming Yan* Construction of Chiral Quaternary Carbon Stereocenters by Asymmetric Michael Addition of 4-Amido-5-hydroxylpyrazoles to Ethylene Sulfonyl Fluoride Asian J. Org. Chem. 2022, e202200063
7. Bizhen Lin, Weiwei Lu, Zhen-yu Chen, Yue Zhang, Yin-zhe Duan, Xiaojie Lu, Ming Yan, and Xue-jing Zhang* Enhancing the Potential of Miniature-Scale DNA-Compatible Radical Reactions via an Electron Donor-Acceptor Complex and a Reversible Adsorption to Solid Support Strategy Org. Lett. 2021, 23, 7381-7385
8. Dong-yu Zhu, Xue-jing Zhang,* and Ming Yan* Enantioselective Addition of Azlactones to Ethylene Sulfonyl Fluoride via Dual Catalysis, Org. Lett. 2021, 23, 4228−4232
9. Jing-xuan Zhou, Dong-yu Zhu, Jie Chen, Xue-jing Zhang*, Ming Yan*, Albert S.C. Chan Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications Tetrahedron Letters 65 (2021) 152792
10. Jie Chen, Dong-yu Zhu, Xue-jing Zhang,* and Ming Yan* Highly Enantioselective Addition of N‑2,2,2-Trifluoroethylisatin Ketimines to Ethylene Sulfonyl Fluoride J. Org. Chem. 2021, 86, 3041−3048
11. Zhen-Yu Chen, Bi-Zhen Lin, Lei Chen, Yong Zou, Ming Yan,* and Xue-Jing Zhang* Perfluorobutyl Iodide-Mediated [1,2] and [2,3] Stevens Rearrangement for the Synthesis of Indolin-3-ones Adv. Synth. Catal. 2020, 362, 4368-4372.
12. Wen-tao Wei, Zhen-yu Chen, Yong-lu Lin, Ri-xing Chen, Qi Wang, Qing-guang Wu, Si-jun Liu,* Ming Yan, and Xue-jing Zhang* Synthesis of Isoindolinones through Intramolecular Amidation of ortho-Vinyl Benzamides Adv. Synth. Catal. 2020, 362, 1972– 1976.
13. Flood, D. T.;# Zhang, X. J.;# （共同一作）Fu, X.; Zhao, Z. X.; Asai, S.; Sanchez, B. B.; Sturgell, E. J.; Vantourout, J. C.; Richardson, P.; Flanagan, M. E.; Piotrowski, D. W.; Kölmel, D. K.; Wan, J. Q.; Chang, Y.; Wang Z.; Chen, J. S.; Baran P. S.;* Dawson, P. E.* RASS-Enabled S/P–C and S–N Bond Formation for DEL Synthesis. Angew. Chem. Int. Ed. 2020, 59, 7377–7383.
14. Dillon T. Flood, # Shota Asai, # （共一） Xuejing Zhang, Jie Wang, Leonard Yoon, Zoë C. Adams, Blythe C. Dillingham, Brittany B. Sanchez, Julien C. Vantourout, Mark E. Flanagan, David W. Piotrowski, Paul Richardson, Samantha A. Green, Ryan A. Shenvi, Jason S. Chen, Phil S. Baran,* and Philip E. Dawson* Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support J. Am. Chem. Soc. 2019, 141, 9998-1000
15. Jie Chen, Bao-qin Huang, Zeng-qing Wang, Xue-Jing Zhang, Ming Yan* Asymmetric Conjugate Addition of Ethylene Sulfonyl Fluorides to 3-Amido-2-oxindoles: Synthesis of Chiral Spirocyclic Oxindole Sultams Org. Lett. 2019, 21, 9742–9746
16. Zhen-Yu Chen, Hua-Ju Liang, Ri-Xing Chen, Lei Chen, Xiang-Zheng Tang, Ming Yan,* and Xue-Jing Zhang,* Cross-Dehygrogenative C-O Coupling of Oximes with Acetonitrile, Ketones and Esters Adv. Synth. Catal. 2019, 361, 3324-3330.
17. Lei Chen, Jie Liang, Zhen-yu Chen, Jie Chen, Ming Yan, * and Xuejing Zhang,* A Convenient Synthesis of Sulfones via Light Promoted Coupling of Sodium Sulfinates and Aryl Halides Adv. Synth. Catal. 2019, 361, 956-960.
18. Lang Tong#, Zhifeng Mao#, Xiangzheng Tang, Xuejing Zhang*, Ming Yan* Cycloaddition of hydrazones and 1, 2-diarylalkynes promoted by t-BuOK/DMF: A convenient synthesis of tetraarylpyrazoles Chin. Chem. Lett. 2019, 30, 395–397.
19. Xiang-zheng Tang, Lang Tong, Hua-ju Liang, Jie Liang, Yong Zou, Xue-jing Zhang, * Ming Yan * and Albert S. C. Chan Facile synthesis of substituted diaryl sulfones via a [3 + 3] benzannulation strategy Org. Biomol. Chem., 2018,16, 3560
20. Chen, Zi-cong; Tong, Lang; Du, Zhi-bo; Mao, Zhi-feng; Zhang, Xue-jing; Zou, Yong; Yan, Ming Annulation of β-​naphthols and 4-​hydroxycoumarins with vinylsulfonium salts: synthesis of dihydrofuran derivatives Organic & Biomolecular Chemistry 2018, 16, 2634-2638.
21. Zhen-yu Chen, Liang-yu Wu, Hai-sheng Fang, Ting Zhang, Zhi-feng Mao, Yong Zou, Xue-jing Zhang and Ming Yan Intramolecular Hydroamidation of ortho-Vinyl Benzamides Promoted by Potassium tert-Butoxide/N,N-Dimethylformamide Adv. Synth. Catal. 2017, 357, 3894–3899.
22. Ting Zhang, Lu Qian, Zhen-yu Chen, Yong Zou, Xue-jing Zhang,* and Ming Yan* Intramolecular dehydrogenative coupling of biaryl tertiary amines promoted with t-BuOK/DMF: A convenient synthesis of 6-aryl-5,6-dihydrophenanthridines Arkivoc 2017, (IV), 174-183.
23. Lin-miao Ye, Jie Chen, Peng Mao, Xue-jing Zhang, Ming Yan* Visible-light promoted synthesis of 3-arylthioindoles from indoles anddiaryl disulfides Tetrahedron Letters, 2017, 58, 2743–2746.
24. Lin-miao Ye, Jie Chen, Peng Mao, Zhi-feng Mao, Xue-jing Zhang, Ming Yan* Visible-light-promoted synthesis of benzothiazoles from 2-aminothiophenols and aldehydes Tetrahedron Letters, 2017, 58, 874-876.
25. Lin-Miao Ye, Lu Qian, Yan-Yan Chen, Xue-Jing Zhang and Ming Yan，A practical synthesis of benzothiophenes via visible-light-promoted cyclization of disulfides and alkynes, Org. Biomol. Chem. 2017, 15, 550–554.
26. Yan-yan Chen, Zhen-yu Chen, Niu-niu Zhang, Jia-hua Chen, Xue-jing Zhang, Ming Yan*, Intramolecular Addition of Triarylmethanes to Alkynes Promoted by KOtBu/DMF: A Synthetic Approach to Indene Derivatives, Eur. J. Org. Chem. 2016, 3, 599-606.
27. Jia-hua Chen, Zi-cong Chen, Hong Zhao, Yong Zou, Xue-jing Zhang* and Ming Yan* Intramolecular cyclization of diarylmethanols and α,β-unsaturated amides promoted by KOt-Bu/DMF: a metal-free approach towards 3,4-disubstituted quinolinones Org. Biomol. Chem., 2016, 14, 11148.
28. Jia-hua Chen, Zi-cong Chen, Hong Zhao, Ting Zhang, Wei-juan Wang, Yong Zou, Xue-jing Zhang* and Ming Yan Intramolecular addition of diarylmethanols to imines promoted by KOt-Bu/DMF: a new synthetic approach to indole derivatives Org. Biomol. Chem., 2016, 14, 4071–4076.
29. Wei-juan Wang, Jia-hua Chen, Zi-cong Chen, Yu-feng Zeng, Xue-jing Zhang*, Ming Yan* Albert S. C. Chan A convenient synthesis of 1-aryl- and 2-aryl-substituted indazolones via intramolecular C–N coupling promoted by KOt-Bu Synthesis, 2016, 48, 3551–3558.
30. Wei-juan Wang, Ting Zhang, Li-jun Duan, Xue-jing Zhang *, Ming Yan * KOt-Bu promoted homocoupling and decomposition of N′-aryl acylhydrazines: synthesis of unsymmetric N′,N′-diaryl acylhydrazines Tetrahedron 2015, 71, 9073-9080.
31. Ri-long Liu, Yun-yun Yan, Ting Zhang, Xue-jing Zhang, Ming Yan* A practical synthesis of optically active d-nitro-a-ketoesters and 4-cyclohexyl-proline catalyzed by chiral squamides Tetrahedron Asymm., 2015, 26, 1416-1422.
32. Wei, Wen-Tao; Ya-Juan Cheng, Yu Hu, Yan-yan Chen, Xue-Jing Zhang; Zou, Yong; Ming Yan * Concise Synthesis of 4-​Arylquinolines via Intramolecular Cyclization of Allylamines and Ketones Adv. Synth. Catal. 2015, 357, 3474-3478.
33. Yan-yan Chen, Zhen-yu Chen, Niu-niu Zhang, Jia-hua Chen, Xue-Jing Zhang; Ming Yan Intramolecular Addition of Triarylmethanes to Alkynes Promoted by KOtBu​/DMF: A Synthetic Approach to Indene Derivatives Eur. J. Org. Chem. 2016, 2016, 599-606.
34. Xiang Sun, Xiao-Hui Lv, Lin-Miao Ye, Yu Hu, Yan-Yan Chen, Xue-Jing Zhang, Ming Yan* Synthesis of benzimidazoles via iridium-catalyzed acceptorless dehydrogenative coupling Org. Biomol. Chem., 2015, 13, 7381–7383.
35. Yan-yan Chen, Niu-niu Zhang, Lin-miao Ye, Jia-hua Chen, Xiang Sun, Xue-jing Zhang, Ming Yan* KOt-Bu/DMF promoted intramolecular cyclization of 1,10-biphenyl aldehydes and ketones: an efficient synthesis of phenanthrenes RSC Adv., 2015, 5, 48046-48049.
36. Yan-yan Chen, Jia-hua Chen, Niu-niu Zhang, Lin-miao Ye, Xue-jing Zhang, Ming Yan* A new synthesis of indoles via intramolecular cyclization of o-alkynyl N,N-dialkylanilines promoted by KOt-Bu/DMSO Tetrahedron Lett. 2015, 56, 478-481.
37. Wen-tao Wei, Yu Liu, Lin-miao Ye, Rong-Hui Lei, Xue-jing Zhang, Ming Yan* Rapid synthesis of isoquinolinones by intramolecular coupling of amides and ketones Org. Biomol. Chem., 2015, 13, 817–824.
38. Yu Hu, Liang Liang, Wen-tao Wei, Xiang Sun, Xue-jing Zhang,* Ming Yan* A convenient synthesis of deuterium labeled amines and nitrogen heterocycles with KOt-Bu/DMSO-d6 Tetrahedron 2015, 71, 1425–14
39. Wei-juan Wang, Xu Zhao, Lang Tong, Jia-hua Chen, Xue-jing Zhang,* and Ming Yan* Direct Inter- and Intramolecular Addition of Amides to Arylalkenes J. Org. Chem. 2014, 79, 8557−8565.
40. Wen-tao Wei, Xue-jiao Dong, Shao-zhen Nie, Yan-yan Chen, Xue-jing Zhang, and Ming Yan* Intramolecular Dehydrative Coupling of Tertiary Amines and Ketones Promoted by KO-t-Bu/DMF: A New Synthesis of Indole Derivatives Org. Lett., 2013, 15 (23), 6018–6021.
41. Yan-yan Chen, Xue-jing Zhang, Hui-min Yuan, Wen-tao Wei and Ming Yan*, Efficient cyclization of tertiary amines and alkenes promoted by KOt-Bu–DMF Chem. Commun., 2013, 49, 10974-10976.
42. Shao-zhen Nie, Xiang Sun, Wen-tao Wei, Xue-jing Zhang, Ming Yan,* and Jian-liang Xiao* Unprecedented Construction of C=C Double Bonds via Ir-Catalyzed Dehydrogenative and Dehydrative Cross-Couplings Org. Lett., 2013, 15 (23), 2394-2397.
43. Xiang Sun, Yu Hu, Shao-zhen Nie, Yun-yun Yan, Xue-jing Zhang, and Ming Yan* Efficient Construction of C=N Double Bonds via Acceptorless Dehydrogenative Coupling Adv. Synth. Catal. 2013, 355, 2179–2184. (IF 5.542)
44. Nian-hua Luo, Xiang Sun, Wen-tao Wei, Xue-jing Zhang*, Ming Yan Asymmetric synthesis of multicyclic spiro-1,3-indandiones via a cascade Michael/Michael reaction of curcumins and 2-arylidene-1,3-indandiones Tetrahedron Asymm. 2013, 24, 402-408.
45. Zhi-Peng Hu, Jian Li, Xiao-Gang Yin, Xue-Jing Zhang,*and Ming Yan Quinine-catalyzed enantioselective tandem conjugate addition /intramolecular cyclization of malononitrile and 1,4-dien-3-ones ARKIVOC 2013 (iii) 1-13.
46. Zhi-Peng Hu, Wei-Juan Wang, Xiao-Gang Yin, Xue-Jing Zhang, Ming Yan* Enantioselective synthesis of 2-amino-4H-pyrans via the organocatalytic cascade reaction of malononitrile and a-substituted chalcones Tetrahedron: Asymmetry 2012, 23, 461–467.
47. Rui-jiong Lu, Wen-tao Wei, Jin-jia Wang, Shao-zhen Nie, Xue-jing Zhang, Ming Yan* Organocatalytic conjugate addition of α-nitroacetates to β,γ-unsaturated α-keto esters and subsequent decarboxylation: synthesis of optically active δ-nitro-α-keto esters Tetrahedron 2012, 68, 9397-9404.
48. Wen-Tao Wei, Chun-Xia Chen, Rui-Jiong Lu, Jin-Jia Wang, Xue-Jing Zhang and Ming Yan* Enantioselective synthesis of 3,3’-dihydropyrryl-spirooxindoles via an organocatalytic three-component reaction Org. Biomol. Chem., 2012, 10, 5245-5252.
49. Eiji Shirakawa*, Xuejing Zhang, Tamio Hayashi* Mizoroki–Heck-Type Reaction Mediated by Potassium tert- Butoxide Angew. Chem. Int. Ed. 2011, 50, 4671-4674 (IF 13.734)
50. Xue-jing Zhang, Sheng-ping Liu, Xue-ming Li, Ming Yan*, Albert S.C. Chan Highly Enantioselective Conjugate Addition of Aldehydes to Nitroolefins Catalyzed by Chiral Bifunctional Sulfamides. Chem. Commun., 2009, 833-835 (Highlight in Synfact: Chiral Sulfamides as Bifunctional Catalysts in Conjugate Addition Reactions).
51. Xue-jing Zhang, Dan Huang, Ming Yan* Catalyzed Addition of Diazoacetoacetates to Imines: Synthesis of Highly Functionalized Aziridines. Org. Biomol. Chem., 2009, 7, 187-192.
52. Xue-jing Zhang, Sheng-ping Liu, Ming Yan* Asymmetric Bifunctional Thiourea Organocatalytic Conjugate Addition of Carbonyl Compounds to Nitroolefins. Tetrahedron Asymm., 2009, 20, 1451-1458.
53. Sheng-ping Liu, Xue-jing Zhang, Jin-hua Lao, Ming Yan* Asymmetric Conjugate Addition of Ketones to Nitroalkenes Catalyzed by Chiral Bifunctional Sulfamides. Arkivoc, 2009, 268-270.
54. Jin-hua Lao, Xue-jing Zhang, Jin-jia Wang, Xue-ming Li, Ming Yan* The Effect of Hydrogen Bond Donors in Asymmetric Organocatalytic Conjugate Addition. Tetrahedron Asymm., 2009, 20, 2818-2822.