照片

吴一诺

副教授

研究领域：靶向磷酸二酯酶的原创候选药物发现及其在纤维化疾病中的应用

办公电话： 020-39943062

联系邮箱： wyinuo3@mail.sysu.edu.cn

简单介绍

吴一诺 博士，副教授，博士生导师。2006年本科毕业于中山大学化学与化学工程学院应用化学专业。2011年毕业于bm11222宝马娱乐网站药物化学专业，获理学博士学位。2011年至2013年于香港理工大学应用生物与化学科技系进行博士后研究。2013年加入bm11222宝马娱乐网站。主要从事"靶向磷酸二酯酶的原创候选药物发现及其在纤维化疾病中的应用"。目前已在 J. Med.Chem,Acta Pharma. Sin. B. Org. Lett., Chem.Commun.等国际权威杂志发表高水平收录论文60余篇。共主持国家自然科学基金等项目9项，并作为课题骨干参与国家科技部重点研发计划。

教育经历

2006/09 - 2011/06，中山大学，bm11222宝马娱乐网站，药物化学，博士

2002/09 - 2006/06，中山大学，化学与化学工程学院，应用化学系，学士

工作经历

2018/04- 至今，中山大学，bm11222宝马娱乐网站，副教授

2013/07 - 2018/04，中山大学，bm11222宝马娱乐网站，讲师

2011/07 - 2013/06，香港理工大学，应用生物与化学科技系，博士后

教学情况

中山大学第十一届教师教学竞赛理科组特等奖

《现代分析技术与应用》

《基础化学》

《大学化学实验》

科研项目

1. 国家自然科学基金面上项目，抗血管性痴呆嘧啶酮类PDE1选择性抑制剂的结构优化与作用机制研究，项目编号：22377155；2024.01 - 2027.12; 50万元

2. 国家自然科学基金面上项目，选择性磷酸二酯酶9型抑制剂的成药性优化及抗肺纤维化作用研究，项目编号：21977127；2020.01 - 2023.12; 66万元

3. 广东省自然科学基金面上项目，高选择性磷酸二酯酶9型抑制剂的设计、成药性优化及其抗血管性痴呆作用研究，项目编号：2019A1515011883；2019.01 - 2022.12; 10万元

4. 广州市科技计划项目珠江科技新星专题，新型萘内酰亚胺类磷酸二酯酶二型抑制剂的合理化设计、合成及其抗阿尔茨海默症药效研究，2018.01 - 2020.12；30万元。

5. 国家自然科学基金青年项目，钯催化下甲苯类酰化试剂参与的邻位和间位C-H酰基化反应，项目编号：21402243；2015.01 - 2017.12; 25万元

6. 中山大学青年教师培育基金，C-H键磷酯方法高效构建苯（杂）环类有机磷化合物新型方法研究，项目编号：13ykpy10；2013.11 - 2016.12；15万元。

7. 国家重点研发计划，课题骨干，基于E 级高性能计算生物医药应用软件系统研制及应用。课题四：癌症、糖尿病与感染性疾病新药研究与软件应用验证, 课题编号：2017YFB0202604; 2017.07 - 2020.12; 749万元。

论著专利

  1. Zhou, Q. #; Le, M.#; Yang, Y.; Wang W.; Huang, Y.; Wang, Q.; Tian, Y.; Jiang, M.; Rao Y.*; Luo, H.-B.*; Wu, Yinuo*, Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation and activating cAMP/CREB axis.Acta Pharmaceutica Sinica B.2023, 13, 1180-1191.(中科院医学一区，Top)

  2. Zhang, B. #;  Yang, Y.#; Zhao, Z-J.#; Wang W.; Huang, Y.; Wang, Q.; Tian, Y.; Jiang, M.; Wang, Q.*; Luo, H.-B.*; Wu, Yinuo*, Identification of novel quinolin-2(1H)-ones as phosphodiesterase 1 inhibitors for the treatment of inflammatory bowel disease. Journal of Medicinal Chemistry.2023, 66, 12468.(中科院医学一区，Top)

  3. Huang, M. X. #; Tian, Y. J. #; Han, C.; Liu, R. D.; Xie, X.; Yuan, Y.; Yang, Y. Y.; Li, Z.; Chen, J.;* Luo, H. B.*; Wu, Yinuo*. Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects.Journal of Medicinal Chemistry.2022, 65, 8444-8455. (中科院医学一区，Top)

  4. Wu, X.-N.#; Qian, Z. #; Huang, Y.-D.; Xie X; Li Z; Wu, Yinuo*; Luo, H.-B.*, Structure-based discovery of orally efficient inhibitors via unique interactions with H-pocket of PDE8 for the treatment of vascular dementia. Acta Pharm. Sin. B 2022, 12, 3103-3112. (中科院医学一区，Top)

  5. Wu Y, Wang Q, Jiang MY, Huang YY, Zhu Z, Han C, et al. Discovery of Potent Phosphodiesterase-9 Inhibitors for the Treatment of Hepatic Fibrosis. Journal of Medicinal Chemistry.2021;64, 9537-49. (中科院医学一区，Top)

  6. Wu Y#, Li Z, Yun-Song Zhao, et al. Therapeutic targets and potential agents for the treatment of COVID-19. Med Res Rev,2021, 41, 1775-1797. (中科院医学一区)

  7. Wu, Y.;  Tian, Y. J.;  Le, M. L.;  Zhang, S. R.;  Zhang, C.;  Huang, M. X.;  Jiang, M. Y.;  Zhang, B.; Luo, H. B., Discovery of Novel Selective and Orally Bioavailable Phosphodiesterase-1 Inhibitors for the Efficient Treatment of Idiopathic Pulmonary Fibrosis. Journal of Medicinal Chemistry.2020,63, 7867-7879. (中科院医学一区，Top)

  8. Wu, Yinuo#; Zhou, Q.#; Zhang, T.#; Li, Z.; Chen, Y. P.; Zhang, P.; Yu, Y. F.; Geng, H.; Tian, Y. J.; Zhang, C.; Wang, Y.; Chen, J. W.*; Chen, Y.*; Luo, H. B.*, Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. Journal of Medicinal Chemistry.2019, 62, 4218-4224. (中科院医学一区，Top)

  9. Huang, Y. Y.; Yu, Y. F.; Zhang, C.; Chen, Y.; Zhou, Q.; Li, Z.; Zhou, S.; Li, Z.; Guo, L.; Wu, D. *; Wu, Yinuo;*; Luo, H. B. *, Validation of Phosphodiesterase-10 as a Novel Target for Pulmonary Arterial Hypertension via Highly Selective and Subnanomolar Inhibitors. Journal of Medicinal Chemistry.2019, 62, 3707-3721.(中科院医学一区，Top)

  10. Wu, Yinuo; Li, Z.; Huang, Y.-Y.; Wu, D.; Luo, H.-B. *, Novel Phosphodiesterase Inhibitors for Cognitive Improvement in Alzheimer's Disease. Journal of Medicinal Chemistry.2018, 61, 5467-5483.(中科院医学一区，Top)

  11. Wu, X. N.; Huang, Y. D.; Li, J.; Yu, Y.-F.;Zhou, Q.; Zhang, C.; Wu, Yinuo*and Luo, H.-B.* Structure-based design, synthesis, and biological evaluation of novel pyrimidinone derivatives as PDE9 inhibitors. Acta Pharmaceutica Sinica B.2018, 8, 615-628.(中科院医学一区，Top)

  12. Li, J.; Chen, J.-Y.; Deng, Y.-L.; Zhou, Q.; Wu, Yinuo*; Wu, D. *; Luo, H.-B., Structure-based design, synthesis, biological evaluation, and molecular docking of novel PDE10 inhibitors with antioxidant activities. Front. Chem. 2018, 6, 167/1-167/12.

  13. Zhang, C.; Zhou, Q.; Wu, X. N.; Huang, Y. D.; Zhou, J.; Lai, Z.; Wu, Yinuo*; Luo, H.-B. Discovery of novel PDE9A inhibitors with antioxidant activities for treatment of Alzheimer’s disease. J. Enzym. Inhib. Med. Chem. 2018,33 (1), 260-270.

  14. Yu, Y. F.; Huang, Y. D.; Zhang, C; Wu, X. N.; Zhou, Q; Wu, D. Y.; Wu, Yinuo*;  Luo, H. B. * Discovery of Novel Pyrazolopyrimidinone Derivatives as  Phosphodiesterase 9A Inhibitors Capable of Inhibiting  Butyrylcholinesterase for Treatment of Alzheimer's Disease. ACS Chem. Neurosci. 2017, 8, 2522.

  15. Zhang, C; Feng, L. J.; Huang, Y. Y.; Wu, D. Y.; Li, Z.; Zhou, Q.; Wu, Yinuo*;  Luo,  H. B.* Discovery of Novel Phosphodiesterase-2A Inhibitors by  Structure-Based Virtual Screening, Structural Optimization, and  Bioassay. J. Chem. Inf. Model. 2017, 57, 355.

  16. Wu, Yinuo;  Jiang, C.; Wu, D.; Gu, Q.; Luo, Z. Y.; Luo, H. B.*. Palladium-catalyzed  C–H bond carboxylation of acetanilides: an efficient usage of N,  N-dimethyloxamic acid as the carboxylate source.Chem. Commun.2016, 52, 1286.

  17. Wu, Yinuo; Sun, L.; Chen, Y.; Zhou, Q.; Huang, J. W.; Miao, H.; Luo, H. B.* Palladium-catalyzed decarboxylative acylation of N-nitrosoanilines with α-oxocarboxylic acids. J. Org. Chem.2016, 81, 1244.

  18. Cai, Y. H.; Guo, Y.; Li, Z.;Wu, D.; Li, X.; Zhang, H.; Yang, J.; Lu, H.; Sun. Z.; Luo, H. B.; Yin, S.*;  Wu, Yinuo*. Discovery and modelling studies of natural ingredients from Gaultheria yunnanensis (FRANCH.) against phosphodiesterase-4. Eur. J. Med. Chem.2016, 114, 134.

  19. Li, Z.; Lu, X.; Feng, L.-J.; Gu, Y.; Li, X.; Wu, Yinuo*; Luo, H.-B.*Molecular dynamics-based discovery of novel phosphodiesterase-9A inhibitors with non-pyrazolopyrimidinone scaffolds.Mol. BioSyst.2015, 11, 115.

  20. Wu, Yinuo;Feng, L. J.; Lu, X.; Kwong, F. Y.*; Luo, H. -B.*. Palladium-catalyzed oxidative C–H bond acylation of N-nitrosoanilines with toluene derivatives: a traceless approach to synthesize N-alkyl-2-aminobenzophenones. Chem. Commun.2014, 50,15352.

  21. Wu, Yinuo; Choy P. Y., Mao F., Kwong F. Y.* Toluene Derivatives as Simple Coupling Precursors for Cascade Palladium-Catalyzed Oxidative C-H bond Acylation of Acetanilides. Chem. Commun. 2013, 49, 689.

  22. Wu, Yinuo;Wong, S. M.; Mao, F.; Chan, T. L.; Kwong, F. Y. * Intramolecular Direct C-H Bond Arylation from Aryl Chlorides: A Transition-Metal-Free Approach for Facile Access of Phenanthridines. Org. Lett. 2012, 14, 5306.

  23. Wu, Yinuo; Wang, J.; Li, P. *; Kwong, F. Y.* Catalyst-free efficient aza-michael addition of azoles to nitroalkenes, Synlett, 2012, 23, 788

  24. Wu, Yinuo;Li, B.; Mao, F.; Li, X.;* Kwong, F. Y.* Palladium -Catalyzed Oxidative C-H Bond Coupling of Steered Acetanilides and Aldehydes: A Facile Access to ortho-Acylacetanilide. Org. Lett. 2011, 13, 3258.

  25. Wu, Yinuo; Mao, F.; Meng, F.; Li. X.* Enantioselective Vanadium-Catalyzed Oxidation of 1,3-Dithianes from Aldehydes and Ketones using beta-Amino Alcohol Derived Schiff Base Ligands. Adv. Synth.Catal.2011,353, 1707.