翁江

翁江，男，1982年11月生，博士，副教授，博士生导师。主要研究领域为药物合成化学和有机合成化学。先后承担国家自然科学基金、广东省自然科学基金重等多项基金项目，在国内外重要学术期刊上发表高水平论文50余篇，申请和获得授权发明专利4项。

2024年招收专业型硕士生2名，欢迎考生联系报考。

联系方式

办公电话：020-39943046

E-mail: wengj2@mail.sysu.edu.cn

研究方向

不对称催化和手性技术

手性药物的高效合成

活性天然产物的全合成

自由基化学

学习和工作经历

2012/7-至今，bm11222宝马娱乐网站，历任讲师和副教授

2017/12-2018/12，美国Scripps研究所，访问学者

2010/07 – 2012/07，bm11222宝马娱乐网站，博士后

2007/09 – 2010/06，bm11222宝马娱乐网站，有机化学专业，博士

2005/09 – 2007/06，中山大学化工学院，有机化学专业，硕士

2001/09 – 2005/06，湖北大学化材学院，应用化学专业，学士

教学情况

有机化学；有机化学实验

科研项目

近年主持的纵向科研项目：

1. 国家自然科学基金-青年科学基金项目：环戊烯酮类前列腺素的合成新方法及其靶向白血病干细胞活性研究；21502240；2016.1-2018.12；

2. 广东省自然科学基金项目-面上项目：基于有机催化串联反应构建环状DPP-4抑制剂及其降血糖活性研究；2015A030313130；2015.8.1-2018.8.1；

3. 广东省自然科学基金项目-博士启动项目：有机催化串联Michael/Wittig/Aldol反应及其在前列腺素合成中的应用；S2013040012409；2013.10-2015.10；

4. 广东省医学科学基金项目：前列腺素F的高效合成新方法研究；A2015167；2015.7-2017.6；

5. 中央高校基本科研业务费-中山大学青年教师培育计划项目：2012.11-2015.11；

6. 中山大学青年教师起步资助计划；2012.12-2013.12

论著专利

发表论文：

37. Wang, Sheng-Cai; Zhou, Xiang; Li, Ying-Xian; Zhang, Chun-Yan; Zhang, Zi-Yan; Xiong, Yan-Shi*; Lu, Gui; Dong, Jiajia*; Weng, Jiang*. Enabling Modular Click Chemistry Library through Sequential Ligations of Carboxylic Acids and Amines.  Angew.Chem., Int.Ed.2024, 63, e202410699.

36.Xiong, Ting; Chen, Qi-Long; Zhang, Zi-Yan; Lu, Gui*; Weng, Jiang*. Direct Fluorosulfonamidation of (Hetero)arenes and Alkenes with Photoredox-Active Fluorosulfamoyl Radical Reagents. ACS Catal.2024, 14, 12082-12092.

35. Xiong, Ting; Hu, Zi-Jun; Wang, Ya-Qi; Weng, Jiang*Enhanced Synthesis of Sulfonyl Fluorides and Sulfamoyl Fluorides Using Fluorosulfonyl-Containing Radical Reagents.Synthesis, 2024, DOI: 10.1055/a-2446-8046. (Invited review, Special issue on SuFEx Chemistry)

34. Zhu, Wen-Run; Su, Qiong; Deng, Xiao-Yi; Ouyang, Ze-Long; Weng, Jiang*; Lu, Gui* Organocatalytic asymmetric cascade bicyclization: access to chiral polycyclic bisindoles from 2-indolylmethanols and propargylic alcohols. Org. Chem. Front. 2024, 11, 2040-2046.

33. Ting Xiong, Qi-Long Chen, Zhi-Da Chen, Ji-Tao Yi, Sheng-Cai Wang, Gui Lu,* Albert S.C. Chan, and Jiang Weng*. Switchable carbo-fluorosulfonylation and hydro-fluorosulfonylation of alkenes enabled by bifunctional fluorosulfonyl radical precursors. Chem Catal.2023, 3, 100821.

32. Jing Guo, Ying Xie, Ze-Min Lai, Jiang Weng*, Albert S. C. Chan, and Gui Lu*. Enantioselective hydroalkylation of alkenylpyridines enabled by merging photoactive electron donor–acceptor complexes with chiral bifunctional organocatalysis. ACS Catal.2022, 12, 13065-13074.

31. Ji-Tao Yi, Xiang Zhou, Zhi-Da Chen, Qi-Long Chen, Gui Lu,* Jiang Weng.* Copper-catalyzed direct decarboxylative fluorosulfonylation of aliphatic carboxylic acids. Chem. Commun., 2022, 58, 9409-9412. (Highlighted by SYNFACTS, 2022, 18, 1806.)

30. Zhi-Da Chen, Xiang Zhou, Ji-Tao Yi, Hong-Juan Diao, Qi-Long Chen, Gui Lu, Jiang Weng.* Catalytic decarboxylative fluorosulfonylation enabled by energy-transfer-mediated photocatalysis. Org. Lett. 2022, 24, 2474-2478. (Selected as Front Cover)

29. Wen-Run Zhu, Qiong Su, Xiao-Yi Deng, Jia-Sheng Liu, Tao Zhong, Shan-Shui Meng, Ji-Tao Yi, Jiang Weng,* Gui Lu.* Organocatalytic enantioselective SN1-type dehydrative nucleophilic substitution: access to bis(indolyl)methanes bearing quaternary carbon stereocenters. Chem. Sci. 2022, 13, 170-177.

28. Tao Zhong, Ji-Tao Yi, Zhi-Da Chen, Quan-Can Zhuang, Yong-Zhao Li, Gui Lu, Jiang Weng.* Photoredox-catalyzed aminofluorosulfonylation of unactivated olefins. Chem. Sci. 2021, 12, 9359-9365.

27. Tao Zhong, Zhi-Da Chen, Ji-Tao Yi, Gui Lu,* Jiang Weng.* Recent progress in the synthesis of sulfonyl fluorides for SuFEx click chemistry. Chin. Chem. Lett. 2021, 32, 2736-2750.

26. Tao Zhong, Meng-Ke Pang, Zhi-Da Chen, Bin Zhang, Jiang Weng,* Gui Lu. Copper-free Sandmeyer-type Reaction for the Synthesis of Sulfonyl Fluorides. Org. Lett. 2020, 22, 3072-3078.

25. Wen-Run Zhu, Qiong Su, Hong-Juan Diao, Er-Xuan Wang, Feng Wu, Yun-Long Zhao, Jiang Weng,* Gui Lu.*  Enantioselective Dehydrative gamma-Arylation of alpha-Indolyl Propargylic Alcohols with Phenols: Access to Chiral Tetrasubstituted Allenes and Naphthopyrans. Org. Lett. 2020, 22, 6873-6878. 

24. Wen-Run Zhu, Kai Liu, Jiang Weng,* Wei-Hua Huang, Wei-Jie Huang, Qing Chen, Ning Lin,* Gui Lu.* Catalytic Asymmetric Synthesis of Vicinal Tetrasubstituted Diamines via Umpolung Cross-Mannich Reaction of Cyclic Ketimines. Org. Lett. 2020, 22, 5014-5019

23. Jing Guo, Ying Xie,  Wen-Tian Zeng, Qiao-Lei Wu, Jiang Weng,* Gui Lu.*  Visible-Light Catalyzed [1+2+2] Cycloaddition Reactions Enabled by the Formation of Methylene Nitrones. Adv. Synth. Catal. 2020, 362: 5450-5456.

22. Wei-Hua Huang, Gong-Bin Huang, Wen-Run Zhu, Jiang Weng,* Gui Lu.* Transition Metal-free Synthesis of α-Aryl Ketones via Oxyallyl Cation Capture with Arylboronic Acids. Org. Chem. Front.2020, 7, 2480-2485.

21. Hang Shi, Yi Lu, Jiang Weng, Katherine L. Bay, Xiangyang Chen, Keita Tanaka, Pritha Verma, Kendall N. Houk,* Jin-Quan Yu.* Differentiation and functionalization of remote C-​H bonds in adjacent positions.  Nature Chem.2020, 12, 399-404.

20. Yan-Shi Xiong, Bin Zhang, Yang Yu, Jiang Weng,* Gui Lu.* Construction of sulfonyl phthalides via copper-catalyzed oxysulfonylation of 2-vinylbenzoic acids with sodium sulfinates. J. Org. Chem. 2019, 84, 13465-13472.

19. Guoqin Xia, Jiang Weng, Luoyan Liu,Pritha Verma, Ziqi Li, Jin-Quan Yu.* Reversing conventional site-​selectivity in C(sp3)​-​H bond activation. Nature Chem. 2019, 11, 571-577.

18. Jing Guo, Gong-Bin Huang, Qiao-Lei Wu, Ying Xie, Jiang Weng,* Gui Lu.* An efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction. Org. Chem. Front. 2019, 6, 1955-1960.

17. Gong-Bin Huang, Wei-Hua Huang, Jing Guo, Xu Dong-Liang, Xiao-Chen Qu, Pei-Hong Zhai, Xiu-Hua Zheng, Jiang Weng,* Gui Lu.* Enantioselective synthesis of  triarylmethanes via organocatalytic 1,6-addition of arylboronic acids to para-quinone methides. Adv. Synth. Catal. 2019, 361, 1241-1246.

16. Yan-Shi Xiong, Jiang Weng,* Gui Lu.* Manganese(III)-mediated and -catalyzed decarboxylative hydroxysulfonylation of arylpropiolic acids with sodium sulfinates in water. Adv. Synth. Catal. 2018, 360, 1611-1616.

15. Jing Guo, Qiao-Lei Wu, Ying Xie, Jiang Weng,* Gui Lu.* Visible-light-mediated decarboxylative benzylation of imines with arylacetic acids. J. Org. Chem. 2018, 83, 12559-12567.

14. Yan-Shi Xiong, Yang Yu, Jiang Weng,* Gui Lu.* Copper-​catalyzed peri-​selective direct sulfenylation of 1-​naphthylamines with disulfides. Org. Chem. Front. 2018, 5, 982-989.

13. Jun-Ming Li, Yong-Heng Wang, Yang Yu, Ruibo Wu, Jiang Weng,* Gui Lu.* Copper-catalyzed remote C–H functionalizations of naphthylamides through coordinating activation strategy and single-electron-transfer (SET) mechanism. ACS Catalysis, 2017, 7, 2661-2667.

12. Jing Guo, Zi-Hui Lin, Kai-Bin Chen, Ying Xie; Albert S. C.Chan, Jiang Weng,* Gui Lu.* Asymmetric amination of 2-substituted indolin-3-ones catalyzed by natural cinchona alkaloids. Org. Chem. Front. 2017, 4, 1400-1406.

10. Wei-Jie Huang, Qing Chen, Ning Lin*, Xian-Wen Long, Wei-Gao Pan, Yan-Shi Xiong, Jiang Weng*, Gui Lu* Asymmetric synthesis of trifluoromethyl-substituted 3,3′-pyrrolidinyl-dispirooxindoles through organocatalytic 1,3-dipolar cycloaddition reactions. Org. Chem. Front., 2017, 4, 472-482.

9. Can Liu, Jiang Weng*, Zi-Hui Lin, Wei-Jie Huang, Jing Guo, Lin-Jie Huang, Gui Lu*, Asymmetric synthesis of vicinal amino alcohols via organocatalytic sequential α-amination/Grignard addition reactions of aldehydes. Tetrahedron: Asymmetry, 2017, 28, 41-46.

8. Ji-Quan Zhang, Yong-Jie Luo, Yan-Shi Xiong, Yang Yu, Zheng-Chao Tu, Zi-Jie Long, Xiao-Ju Lai, Hui-Xuan Chen, Yu Luo, Jiang Weng, Gui Lu. Design, Synthesis, and Biological Evaluation of Substituted Pyrimidines as Potential Phosphatidylinositol 3-Kinase (PI3K) Inhibitors. J. Med. Chem. 2016, 59, 7268–7274. 

7. Jun-Ming Li, Jiang Weng,* Gui Lu, Albert S.C. Chan. Copper-catalyzed C5-regioselective C-H sulfonylation of 8-aminoquinoline amides with aryl sulfonyl chlorides. Tetrahedron Lett., 2016, 57, 2121-2124. 

6. Jing Guo, Jiang Weng,* Gong-Bin Huang,  Lin-Jie Huang, Albert S. C. Chan,  Gui Lu.* Indoxyl-based umpolung strategy for the synthesis of unsymmetrical 3,3'-biindoles. Tetrahedron Lett., 2016, 57, 5493-5496. 

5. Jiang Weng,* Sheng Wang, Lin-Jie Huang , Zhang-Yi Luo, Gui Lu.*  Stereoselective Synthesis of Epoxyisoprostanes: An Organocatalytic and "Pot-economy" Approach. Chem. Commun. 2015, 51, 10170-10173. (Highlighted by Organic Chemistry Portal)

4. Lin-Jie Huang, Jiang Weng,* Sheng Wang, Gui Lu.* Organocatalytic Diels-Alder Reaction of 2-Vinylindoles with Methyleneindolinones: An Efficient Approach to Functionalized Carbazolespirooxindoles. Adv. Synth. Catal.2015, 357(5), 993-1003.  (Highlighted by X-MOL)

3. Jiang Weng, Jun-Ming Li, Feng-Quan Li, Zhi-Sheng Xie, Gui Lu.* Asymmetric domino nitro-Michael/Horner-Wadsworth-Emmons reaction for disubstituted cyclohexenecarboxylate annulation: efficient synthesis of DPP-4 inhibitor ABT-341 and influenza neuraminidase inhibitors. Adv. Synth. Catal., 2012, 354, 1961-1970.

2. Jiang Weng, Yong-Bo Li, Rui-Bin Wang, Gui Lu. Organocatalytic Michael reaction of nitroenamines with aldehydes: efficient asymmetric synthesis of (−)-oseltamivir. ChemCatChem, 2012, 4, 1007-1012. (Invited paper)

1. Jiang Weng,Yong-Bo Li, Rui-Bin Wang, Feng-Quan Li, Can Liu, Albert S. C. Chan, Gui Lu. A practical and azide-free synthetic approach to oseltamivir from diethyl D-tartrate. J. Org. Chem., 2010, 75, 3125-3128. (Highlighted by SYNFACTS, 2010, 8, 857) 

发明专利

授权专利：

1. Process for the preparation of 1-nitro-4-oxobutanylamides. European Patent application, EP 11164806.9. Juraj Rehak, Gui Lu, Julius Durmis, Jiang Weng, Henrich Brath, Yong-Bo Li, Martin Hutka, Stefan Toma, Attila Latika. （欧洲发明专利）

2. 一种具有流感病毒神经胺酸酶抑制活性的环己烯衍生物的制备，中国发明专利。 201110257557.X. 发明人：鲁桂、黎逢权、翁江、李勇波

3.  一种3，3’-双 吲哚化合物的制备方法，中国发明专利。申请号：201610133055.9 发明人：翁江、鲁桂、郭靖

申请专利：

1.  一种醋酸阿比特龙酯的制备方法，中国发明专利。申请号：201410426938.X. 发明人：翁江、鲁桂、黄琳杰、王尧