唐贵华
副教授
研究领域：天然药物化学
联系邮箱： tanggh5@mail.sysu.edu.cn
联系方式
电子邮箱：tanggh5@mail.sysu.edu.cn
办公地址：中国广州大学城外环东路132号bm11222宝马娱乐网站 510006
简单介绍
bm11222宝马娱乐网站副教授，博士生导师，主要从事药用植物化学与新药研发等方面工作。
研究方向
天然药物化学
招生计划
2024年招收生药学方向学术型硕士生1名和药学专业型硕士生1名，欢迎考生报考。
教育经历
2010/09 – 2013/07，中国科学院昆明植物研究所，药物化学专业，理学博士，导师：郝小江 院士
2007/09 – 2010/06，中国科学院昆明植物研究所，植物学专业，理学硕士，导师：龙春林 研究员
2003/09 – 2007/06，湖南师范大学，生命科学学院，生物科学专业，理学学士
工作经历
2019/01至今，bm11222宝马娱乐网站，副教授
2013/07 – 2019/01，bm11222宝马娱乐网站，讲师
教学情况
承担《天然药物化学实验》、《天然药物化学》、《生药学实验》、《生药学》、《生药学野外实习》等课程教学。
科研项目（主持和参与）
12. 国家自然科学基金委员会面上项目 (81973203), 55万元, 2020.01–2023.12, 主持.
11. 广东省自然科学基金面上项目 (2020A1515010841), 10万元, 2019.10.01-2022.09.30, 主持.
10. 国家自然科学基金委员会青年科学基金 (81402813), 24万元, 2015.01–2017.12, 主持.
9. 中山大学青年教师培育项目 (14YKPY10), 15万元, 2014.07–2017.07, 主持.
8. 广东省普通高校青年创新人才项目 (2014KQNCX007), 10万元, 2014.07–2017.07, 主持.
7. 国家自然科学基金委员会面上项目 (21672266), 65万元, 2017.01-2020.12, 第一参与人.
6. 国家自然科学基金委员会面上项目 (81573302), 60万元, 2016.01-2019.12, 第一参与人.
5. 国家自然科学基金委员会面上项目 (81473319), 68万元, 2015.01-2018.12, 第一参与人.
4. 国家自然科学基金委员会面上项目 (21372228), 80万元, 2014.01-2017.12, 第一参与人.
3. 国家自然科学基金委员会面上项目 (31270404), 80万元, 2013.01-2016.12, 第一参与人.
2. 广东省省级科技计划项目 (2015A020211007), 30万元, 2016.01.01-2018.12.31, 第一参与人.
1. 中山大学青年教师重点培育项目 (17ykzd12), 30万元, 2017.01.01-2018.12.31, 第一参与人.
研究论文 (#共同一作, *通讯作者)
32. Luo, Si-Yuan; Tang, Zhuo-Ya; Li, Qingjiang; Weng, Jiang; Yin, Sheng; Tang, Gui-Hua*, Total synthesis of mulberry Diels–Alder-type adducts kuwanons G and H. The Journal of Organic Chemistry 2021, 86, 4786–4793, DOI: 10.1021/acs.joc.1c00229.
31. Huang, Jia-Luo#; Fan, Run-Zhu#; Zou, Yi-Hong; Zhang, Lei; Yin, Sheng; Tang, Gui-Hua*, Salviplenoid A from Salvia plebeia attenuates acute lung inflammation via modulating NF-κB and Nrf2 signaling pathways. Phytotherapy Research 2021, 35, 1559–1571, DOI: 10.1002/ptr.6922.
30. Tang, Zhuo-Ya; Fan, Run-Zhu; Yin, Ai-Ping; Tang, Di-Kai; Ahmed, Abrar; Cao, Jin; Yin, Sheng; Pu, Rong*; Tang, Gui-Hua*, Flavonoids with anti-inflammatory activities from Daphne giraldii. Arabian Journal of Chemistry 2021, 14, 102962, DOI: 10.1016/j.arabjc.2020.102962.
29. Wang, Rong; Fan, Run-Zhu; Ni, Fu-Qiang; Sang, Jun; Xie, Xing-Lin; Luo, Si-Yuan; Tang, Gui-Hua*; Yin, Sheng*, 19-nor-, 20-nor-, and tetranor-Halimane-type furanoditerpenoids from Croton crassifolius. Journal of Natural Products 2020, 83, 255–267, DOI: 10.1021/acs.jnatprod.9b00634.
28. Luo, Si-Yuan; Pu, Rong; Tang, Ya-Qi; Fan, Run-Zhu; Yin, Sheng; Tang, Gui-Hua*, Euphane- and 19(10→9)abeo-euphane-type triterpenoids from Jatropha gossypiifolia. Fitoterapia 2020, 143, 104582, DOI: 10.1016/j.fitote.2020.104582
27. Wang, Rong; Ni, Fu-Qiang; Sang, Jun; Zhang, Yao; Huang, Jia-Luo; Yin, Sheng; Tang, Gui-Hua*, Toonapolyynes A–D, new polyynes from Toona ciliata. Natural Product Research 2020, 34, 935–942, DOI: 10.1080/14786419.2018.1542392.
26. Tang, Gui-Hua#; Lu, Na#; Li, Wei; Chen, Yun-Yun; Wu, Min; Zhang, Hai-Ying; He, Shao-Yun*, Mannosylxylarinolide, a new 3,4-seco-ergostane-type steroidal saponin featuring a β-D-mannose from the endophytic fungus Xylaria sp. Journal of Asian Natural Products Research 2020, 22, 397–403, DOI: 10.1080/10286020.2018.1563075.
25. Song, Qin-Qin#; Rao, Yong#; Tang, Gui-Hua#; Sun, Zhang-Hua; Zhang, Jun-Sheng; Huang, Zhi-Shu*; Yin, Sheng*, Tigliane diterpenoids as a new type of antiadipogenic agents inhibit GRα-Dexras1 axis in adipocytes. Journal of Medicinal Chemistry 2019, 62, 2060–2075, DOI: 10.1021/acs.jmedchem.8b01693.
24. Xia, Chun-Li#; Tang, Gui-Hua#; Guo, Yan-Qiong; Xu, You-Kai; Huang, Zhi-Shu*; Yin, Sheng*, Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease. Phytochemistry 2019, 157, 82–91, DOI: 10.1016/j.phytochem.2018.10.028.
23. Jiang, Cheng-Shi#; Guo, Yan-Qiong#; Yin, Sheng; Zhang, Hua*; Tang, Gui-Hua*, A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus. Journal of Asian Natural Products Research 2019, 21, 377–383, DOI: 10.1080/10286020.2018.1424138.
22. Guo, Yan-Qiong#; Tang, Gui-Hua#; Lou, Lan-Lan; Li, Wei; Zhang, Bei; Liu, Bo; Yin, Sheng*, Prenylated flavonoids as potent phosphodiesterase-4 inhibitors from Morus alba: Isolation, modification, and structure-activity relationship study. European Journal of Medicinal Chemistry 2018, 144, 758–766, DOI: 10.1016/j.ejmech.2017.12.057.
21. Zou, Yi-Hong; Zhao, Liang; Xu, You-Kai; Bao, Jing-Mei; Liu, Xin; Zhang, Jun-Sheng; Li, Wei; Ahmed, Abrar; Yin, Sheng; Tang, Gui-Hua*, Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia: Regulates pro-inflammatory mediators through inhibition of NF-κB and Erk1/2 signaling pathways in LPS-induced Raw264.7 cells. Journal of Ethnopharmacology 2018, 210, 95–106, DOI: 10.1016/j.jep.2017.08.034.
20. Chen, Lin; Liu, Bo; Deng, Jun-Jie; Zhang, Jun-Sheng; Li, Wei; Ahmed, Abrar; Yin, Sheng; Tang, Gui-Hua*, Lindera cyclopentenedione intermediates from the roots of Lindera aggregata. RSC Advances 2018, 8, 17898–17904, DOI: 10.1039/C8RA03094D.
19. Ahmed, Abrar; Li, Wei; Chen, Fang-Fang; Zhang, Jun-Sheng; Tang, Ya-Qi; Chen, Lin; Tang, Gui-Hua*; Yin, Sheng, Monoterpene indole alkaloids from Rhazya stricta. Fitoterapia 2018, 128, 1–6, DOI: 10.1016/j.fitote.2018.04.018.
18. Ahmed, Abrar; Li, Wei; Zhang, Jun-Sheng; Sam, Pek-Ha; Zou, Yi-Hong; Tang, Gui-Hua*; Yin, Sheng, A new bisabolane sesquiterpenoid and a new abietane diterpenoid from Cephalotaxus sinensis. Natural Product Research 2018, 32, 175–181, DOI: 10.1080/14786419.2017.1343323.
17. Li, Wei#; Tang, Gui-Hua#; Chen, Lin; Tang, Ya-Qi; Xu, You-Kai; Liu, Bo*; Yin, Sheng*, New pyridocarbazole alkaloids from Strychnos nitida. Natural Product Research 2018, 32, 1532–1536, DOI: 10.1080/14786419.2017.1385016.
16. Liu, Xin#; Tang, Gui-Hua#; Weng, Han-Zhuang; Zhang, Jun-Sheng; Xu, You-Kai; Yin, Sheng*, A new selaginellin derivative and a new triarylbenzophenone analogue from the whole plant of Selaginella pulvinata. Journal of Asian Natural Products Research 2018, 20, 1123–1128.
15. Tang, Gui-Hua#; Dong, Zhen#; Guo, Yan-Qiong; Cheng, Zhong-Bin; Zhou, Chu-Jun; Yin, Sheng*, Psiguajadials A–K: Unusual Psidium meroterpenoids as phosphodiesterase-4 inhibitors from the leaves of Psidium guajava. Scientific Reports 2017, 7, 1047–1061, DOI: 10.1038/s41598-017-01028-4.
14. Li, Wei; Zhang, Jun-Sheng; Huang, Jia-Luo; Jiang, Min-Hong; Xu, You-Kai; Ahmed, Abrar; Yin, Sheng; Tang, Gui-Hua*, New prenylated coumarins from the stems of Toddalia asiatica. RSC Advances 2017, 7, 31061–31068, DOI: 10.1039/C7RA04794K.
13. Zhang, Jun-Sheng; Huang, Jia-Luo; Zou, Yi-Hong; Liu, Xin; Ahmed, Abrar; Tang, Gui-Hua*; Yin, Sheng, Novel degraded polycyclic polyprenylated acylphloroglucinol and new polyprenylated benzophenone from Hypericum sampsonii. Phytochemistry Letters 2017, 21, 190–193, DOI: 10.1016/j.phytol.2017.06.023.
12. Sun, Zhang-Hua; Li, Wei; Tang, Gui-Hua*; Yin, Sheng, A new serratene triterpenoid from Lycopodium japonicum. Journal of Asian Natural Products Research 2017, 19, 299–303, DOI: 10.1080/10286020.2016.1208182.
11. Li, Wei#; Lou, Lan-Lan#; Zhu, Jian-Yong; Zhang, Jun-Sheng; Liang, An-An; Bao, Jing-Mei; Tang, Gui-Hua*; Yin, Sheng, New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense. Fitoterapia 2016, 115, 24–30, DOI: http://dx.doi.org/10.1016/j.fitote.2016.09.010.
10. Zhang, Jun-Sheng; Zou, Yi-Hong; Zhao, Jing-Jun; Chen, Ye; Bao, Jing-Mei; Tang, Gui-Hua*, Three new diterpenoids from Marrubium aschersonii. Phytochemistry Letters 2016, 16, 241–244, DOI: 10.1016/j.phytol.2016.05.004.
9. Zou, Yi-Hong; Liu, Xin; Liu, Ye-Na; Tang, Gui-Hua*; Yin, Sheng, A novel heterodimer from Crotalaria ferruginea. Natural Product Communications 2016, 11, 793–794.
8. Tang, Gui-Hua; Sun, Zhang-Hua; Zou, Yi-Hong; Yin, Sheng*, New cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton ehrenbergi. Molecules 2016, 21, 587–593, DOI: 10.3390/molecules21050587.
7. Zhu, Jian-Yong; Li, Wei; Bao, Jing-Mei; Zhang, Jun-Sheng; Yin, Sheng; Tang, Gui-Hua*, Diterpenoids from the South China Sea soft coral Sarcophyton solidum. Biochemical Systematics and Ecology 2015, 62, 6–10, DOI: 10.1016/j.bse.2015.07.033.
6. Tang, Gui-Hua#; Chen, Zi-Wei#; Lin, Ting-Ting; Tan, Min; Gao, Xiao-Yun; Bao, Jing-Mei; Cheng, Zhong-Bin; Sun, Zhang-Hua; Huang, Gang; Yin, Sheng*, Neolignans from Aristolochia fordiana prevent oxidative stress-induced neuronal death through maintaining the Nrf2/HO-1 pathway in HT22 cells. Journal of Natural Products 2015, 78, 1894–1903, DOI: 10.1021/acs.jnatprod.5b00220.
5. Tang, Gui Hua; Zhang, Yu; Yuan, Chun Mao; Li, Yan; Gu, Yu Cheng; Di, Ying Tong; Wang, Yue Hu; Zuo, Guo Ying; Li, Shi Fei; Li, Shun Lin; He, Hong Ping*; Hao, Xiao Jiang*, Trigohowilols A–G, degraded diterpenoids from the stems of Trigonostemon howii. Journal of Natural Products 2012, 75, 1962–1966, DOI: 10.1021/np3006315.
4. Tang, Gui Hua; Zhang, Yu; Gu, Yu Cheng; Li, Shi Fei; Di, Ying Tong; Wang, Yue Hu; Yang, Cui Xian; Zuo, Guo Ying; Li, Shun Lin; He, Hong Ping; Hao, Xiao Jiang, Trigoflavidols A–C, degraded diterpenoids with antimicrobial activity, from Trigonostemon flavidus. Journal of Natural Products 2012, 75, 996–1000, DOI: 10.1021/np3001128.
3. Tang, Gui Hua; He, Hong Ping; Gu, Yu Cheng; Di, Ying Tong; Wang, Yue Hu; Li, Shi Fei; Li, Shun Lin; Zhang, Yu*; Hao, Xiao Jiang*, 3,4-seco-Diterpenoids from Trigonostemon flavidus. Tetrahedron 2012, 68, 9679–9684, DOI: 10.1016/j.tet.2012.09.052.
2. Tang, Gui Hua; Chen, Dong Mei; Qiu, Bei Ying; Sheng, Li; Wang, Yue Hu; Hu, Guang Wan; Zhao, Fu Wei; Ma, Li Juan; Wang, Huan; Huang, Qiao Qin; Xu, Jin Jin; Long, Chun Lin*; Li, Jia*, Cytotoxic amide alkaloids from Piper boehmeriaefolium. Journal of Natural Products 2011, 74, 45–49, DOI: 10.1021/np100606u.
1. Tang, Gui Hua; Sun, Chang Song; Long, Chun Lin*; Li, Ma Lin*; Wang, Yue Hu; Luo, Min; Wang, Hong Sheng; Shi, Ya Na, Sesquiterpenoids from Pilea cavaleriei subsp crenata. Bioorganic & Medicinal Chemistry Letters 2009, 19, 5737–5740, DOI: 10.1016/j.bmcl.2009.08.001.
授权专利
2. 尹胜; 黄志纾; 饶勇; 唐贵华; 宋芹芹, 一类惕格烷型二萜化合物及其制备方法和应用. ZL201810522191.6, 2020.04.17 (授权日期).
1. 尹胜; 唐贵华; 张君生; 刘信, 一种天然产物selaginpulvilin的衍生物及其制备方法和应用. ZL201611043917.5, 2020.05.08 (授权日期).
