唐贵华

联系方式

电子邮箱：tanggh5@mail.sysu.edu.cn

办公地址：中国广州大学城外环东路132号bm11222宝马娱乐网站 510006

简单介绍

bm11222宝马娱乐网站副教授，博士生导师，主要从事药用植物化学与新药研发等方面工作。

研究方向

天然药物化学

招生计划

2024年招收生药学方向学术型硕士生1名和药学专业型硕士生1名，欢迎考生报考。

教育经历

2010/09 – 2013/07，中国科学院昆明植物研究所，药物化学专业，理学博士，导师：郝小江 院士

2007/09 – 2010/06，中国科学院昆明植物研究所，植物学专业，理学硕士，导师：龙春林 研究员

2003/09 – 2007/06，湖南师范大学，生命科学学院，生物科学专业，理学学士

工作经历

2019/01至今，bm11222宝马娱乐网站，副教授

2013/07 – 2019/01，bm11222宝马娱乐网站，讲师

教学情况

承担《天然药物化学实验》《天然药物化学》《药用植物学》《生药学实验》《生药学》《生药学野外实习》等课程教学。

科研项目（主持和参与）

12.   国家自然科学基金委员会面上项目 (81973203), 55万元, 2020.01–2023.12, 主持.

11.   广东省自然科学基金面上项目 (2020A1515010841), 10万元, 2019.10.01-2022.09.30, 主持.

10.   国家自然科学基金委员会青年科学基金 (81402813), 24万元, 2015.01–2017.12, 主持.

9.     中山大学青年教师培育项目 (14YKPY10), 15万元, 2014.07–2017.07, 主持.

8.     广东省普通高校青年创新人才项目 (2014KQNCX007), 10万元, 2014.07–2017.07, 主持.

7.     国家自然科学基金委员会面上项目 (21672266), 65万元, 2017.01-2020.12, 第一参与人.

6.     国家自然科学基金委员会面上项目 (81573302), 60万元, 2016.01-2019.12, 第一参与人.

5.     国家自然科学基金委员会面上项目 (81473319), 68万元, 2015.01-2018.12, 第一参与人.

4.     国家自然科学基金委员会面上项目 (21372228), 80万元, 2014.01-2017.12, 第一参与人.

3.     国家自然科学基金委员会面上项目 (31270404), 80万元, 2013.01-2016.12, 第一参与人.

2.     广东省省级科技计划项目 (2015A020211007), 30万元, 2016.01.01-2018.12.31, 第一参与人.

1.     中山大学青年教师重点培育项目 (17ykzd12), 30万元, 2017.01.01-2018.12.31, 第一参与人.

研究论文 (#共同一作, *通讯作者)

48.   Li, Lei#; Zhu, Xin-Ying#; Zhu, Jun-Yu; Wu, Zhi-Hao; Zhang, Yan-Jiang; Yuan, Fang-Yu; Huang, Dong; Yin, Sheng*; Tang, Gui-Hua*. Penispirolactam and penipyrroloindole, two unusual polycyclic indole diterpenoids with anti-hepatic fibrosis activity from the endophytic fungus Penicillium janthinellum H-6. Chinese Chemical Letters 2025, 111161, DOI: 10.1016/j.cclet.2025.111161.

47.   Wu, Shu-Qi#; Zhu, Xinying#; Yuan, Fang-Yu; Weng, Han-Zhuang; Li, Lei; Huang, Dong; Tang, Gui-Hua*; Yin, Sheng*. Malbrumpenoids A-N, unusually cyclized triterpenoids from the Euphorbia endophyte Malbranchea umbrina D16. Chinese Chemical Letters 2025, 111336, DOI: 10.1016/j.cclet.2025.111336.

46.   Li, Lei#; Zhu, Xin-Ying#; Zhu, Jun-Yu#; Cui, Qing-Ya; Lin, Yu-Wei; Lu, Qing-Ren; Wu, Shu-Qi; Fu, Yi-Fan; Zhou, Qi-Lang; Yuan, Tao; Sun, Zhang-Hua; Huang, Dong; Yuan, Fang-Yu; Yin, Sheng; Tang, Gui-Hua*. HSQC-guided discovery and structural optimization of antiadipogenic indole diterpenoids from endophytic fungus Penicillium janthinellum H-6. European Journal of Medicinal Chemistry 2025, 297, 117956, DOI: 10.1016/j.ejmech.2025.117956.

45.   Lu, Qing-Ren; Li, Lei; Cui, Qing-Ya; Liao, Qiong; Malik, Nirmal; Wu, Lei-Ming; Liao, Yi-Ling; Wu, Shu-Qi; Yuan, Fang-Yu; Yin, Sheng; Huang, Jia-Luo*; Tang, Gui-Hua*. Sclerotiorin-type azaphilones isolated from a marine-derived fungus Microsphaeropsis arundinis P1B. Journal of Natural Products 2025, 88 , 1075-1084, DOI: 10.1021/acs.jnatprod.5c00169.

44.   Wu, Wei-Ye#; Wei, Xun#; Liao, Qiong; Fu, Yi-Fan; Wu, Lei-Ming; Li, Lei; Wu, Shu-Qi; Lu, Qing-Ren; Yuan, Fang-Yu; Huang, Dong; Sun, Zhang-Hua; Yuan, Tao; Tang, Gui-Hua*. Structurally diverse polyketides and alkaloids produced by a plant-derived fungus Penicillium canescens L1. Natural Products and Bioprospecting 2025, 15, 22, DOI: 10.1007/s13659-025-00503-0.

43.   Wang, Yan#; Song, Shao-Hua#; Wu, Lei-Ming; Zhou, Xue; Lu, Qing-Ren; Yin, Ai-Ping; Yin, Sheng; Tang, Gui-Hua*. Chemical constituents of Penicillium ferraniaense GE-7 and their cytotoxicities. Natural Product Research 2025, 39, 3915–3922, DOI: 10.1080/14786419.2024.2324113.

42.   Chen, Jia-Qian; Li, Shen; Fan, Run-Zhu; Sun, Zhang-Hua; Zhu, Xin-Ying; Yin, Ai-Ping; Tang, Gui-Hua*; Yin, Sheng. Talaesthanes A–C, three new meroterpenoids from the endophytic fungus Talaromyces primulinus H21. Fitoterapia 2024, 177, 106085, DOI: 10.1016/j.fitote.2024.106085.

41.   Zhu, Jun-Yu; Weng, Han-Zhuang; Tang, Di-Kai; Long, Jin-Chen; Tang, Zhuo-Ya; Chen, Ye; Yin, Sheng; Tang, Gui-Hua*. Prenylated dihydroflavones from the root barks of Morus alba. Natural Product Research 2024, 38 , 2569-2576, DOI: 10.1080/14786419.2023.2189710.

40.   Lu, Qing-Ren#; Wang, Yan#; Tang, Zhuo-Ya; Chen, Ye; Weng, Han-Zhuang; Yin, Sheng; Tang, Gui-Hua*. Chemical constituents of Wikstroemia alternifolia and their neuroprotective activities. Natural Product Research 2024, 38, 986-993, DOI: 10.1080/14786419.2023.2209821.

39.   Yuan, Fang-Yu#; Tang, Zhuo-Ya#; Yan, Xue-Long; Huang, Dong; Weng, Han-Zhuang; Huang, Jia-Luo; Fan, Run-Zhu; Chen, Ye; Yin, Sheng; Tang, Gui-Hua*. Diversity of sesquiterpenoids from Stellera chamaejasme with neuroprotective effects. Phytochemistry 2023, 208, 113588, DOI: 10.1016/j.phytochem.2023.113588.

38.   Wei, Xun; Huang, Jia-Luo; Gao, Hua-Hua; Yuan, Fang-Yu; Tang, Gui-Hua*; Yin, Sheng*. New halimane and clerodane diterpenoids from Croton cnidophyllus. Natural Products and Bioprospecting 2023, 13, 21, DOI: 10.1007/s13659-023-00386-z.

37.   Su, Tong; Pu, Mei-Cen; Tang, Di-Kai; Long, Jin-Chen; Yuan, Fang-Yu; Yin, Ai-Ping; Wu, Shu-Qi; Yin, Sheng; Tang, Gui-Hua*. New benzofuran neolignans with neuroprotective activity from Phyllanthodendron breynioides. Natural Product Research 2023, 37, 3798-3805, DOI: 10.1080/14786419.2022.2153454.

36.   Zou, Ming-Feng#; Fan, Run-Zhu#; Yin, Ai-Ping; Hu, Rong; Huang, Dong; Li, Wei; Yin, Sheng; Pu, Rong*; Tang, Gui-Hua*. Discovery of 29-O-acyl-toosendanin-based derivatives as potent anti-cancer agents. Arabian Journal of Chemistry 2022, 15, 104283, DOI: 10.1016/j.arabjc.2022.104283. 

35.   Luo, Si-Yuan; Zhu, Jun-Yu; Zou, Ming-Feng; Yin, Sheng; Tang, Gui-Hua*. Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis. Natural Products and Bioprospecting 2022, 12, 31, DOI: 10.1007/s13659-022-00355-y. 

34.   Weng, Han-Zhuang; Zhu, Jun-Yu; Yuan, Fang-Yu; Tang, Zhuo-Ya; Tian, Xiao-Qing; Chen, Ye; Fan, Cheng-Qi*; Tang, Gui-Hua*; Yin, Sheng. Homo/hetero-dimers of aromatic bisabolane sesquiterpenoids with neuroprotective activity from the fungus Aspergillus versicolor A18 from south China sea. Marine Drugs 2022, 20, 322, DOI: 10.3390/md20050322.

33.   Weng, Han-Zhuang#; Tian, Yang#; Zhang, Jun-Sheng; Huang, Jia-Luo; Tang, Gui-Hua*; Yin, Sheng*. A new tigliane-type diterpenoid from Euphorbia tirucalli. Natural Product Research 2022, 36, 5380-5386. DOI: 10.1080/14786419.2021.1938039.

32.   Luo, Si-Yuan; Tang, Zhuo-Ya; Li, Qingjiang; Weng, Jiang; Yin, Sheng; Tang, Gui-Hua*, Total synthesis of mulberry Diels–Alder-type adducts kuwanons G and H. The Journal of Organic Chemistry 2021, 86, 4786–4793, DOI: 10.1021/acs.joc.1c00229.

31.   Huang, Jia-Luo#; Fan, Run-Zhu#; Zou, Yi-Hong; Zhang, Lei; Yin, Sheng; Tang, Gui-Hua*, Salviplenoid A from Salvia plebeia attenuates acute lung inflammation via modulating NF-κB and Nrf2 signaling pathways. Phytotherapy Research 2021, 35, 1559–1571, DOI: 10.1002/ptr.6922.

30.   Tang, Zhuo-Ya; Fan, Run-Zhu; Yin, Ai-Ping; Tang, Di-Kai; Ahmed, Abrar; Cao, Jin; Yin, Sheng; Pu, Rong*; Tang, Gui-Hua*, Flavonoids with anti-inflammatory activities from Daphne giraldii. Arabian Journal of Chemistry 2021, 14, 102962, DOI: 10.1016/j.arabjc.2020.102962.

29.   Wang, Rong; Fan, Run-Zhu; Ni, Fu-Qiang; Sang, Jun; Xie, Xing-Lin; Luo, Si-Yuan; Tang, Gui-Hua*; Yin, Sheng*, 19-nor-, 20-nor-, and tetranor-Halimane-type furanoditerpenoids from Croton crassifolius. Journal of Natural Products 2020, 83, 255–267, DOI: 10.1021/acs.jnatprod.9b00634.

28.   Luo, Si-Yuan; Pu, Rong; Tang, Ya-Qi; Fan, Run-Zhu; Yin, Sheng; Tang, Gui-Hua*, Euphane- and 19(10→9)abeo-euphane-type triterpenoids from Jatropha gossypiifolia. Fitoterapia 2020, 143, 104582, DOI: 10.1016/j.fitote.2020.104582

27.   Wang, Rong; Ni, Fu-Qiang; Sang, Jun; Zhang, Yao; Huang, Jia-Luo; Yin, Sheng; Tang, Gui-Hua*, Toonapolyynes A–D, new polyynes from Toona ciliata. Natural Product Research 2020, 34, 935–942, DOI: 10.1080/14786419.2018.1542392.

26.   Tang, Gui-Hua#; Lu, Na#; Li, Wei; Chen, Yun-Yun; Wu, Min; Zhang, Hai-Ying; He, Shao-Yun*, Mannosylxylarinolide, a new 3,4-seco-ergostane-type steroidal saponin featuring a β-D-mannose from the endophytic fungus Xylaria sp. Journal of Asian Natural Products Research 2020, 22, 397–403, DOI: 10.1080/10286020.2018.1563075.

25.   Song, Qin-Qin#; Rao, Yong#; Tang, Gui-Hua#; Sun, Zhang-Hua; Zhang, Jun-Sheng; Huang, Zhi-Shu*; Yin, Sheng*, Tigliane diterpenoids as a new type of antiadipogenic agents inhibit GRα-Dexras1 axis in adipocytes. Journal of Medicinal Chemistry 2019, 62, 2060–2075, DOI: 10.1021/acs.jmedchem.8b01693.

24.   Xia, Chun-Li#; Tang, Gui-Hua#; Guo, Yan-Qiong; Xu, You-Kai; Huang, Zhi-Shu*; Yin, Sheng*, Mulberry Diels-Alder-type adducts from Morus alba as multi-targeted agents for Alzheimer's disease. Phytochemistry 2019, 157, 82–91, DOI: 10.1016/j.phytochem.2018.10.028.

23.   Jiang, Cheng-Shi#; Guo, Yan-Qiong#; Yin, Sheng; Zhang, Hua*; Tang, Gui-Hua*, A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus. Journal of Asian Natural Products Research 2019, 21, 377–383, DOI: 10.1080/10286020.2018.1424138.

22.   Guo, Yan-Qiong#; Tang, Gui-Hua#; Lou, Lan-Lan; Li, Wei; Zhang, Bei; Liu, Bo; Yin, Sheng*, Prenylated flavonoids as potent phosphodiesterase-4 inhibitors from Morus alba: Isolation, modification, and structure-activity relationship study. European Journal of Medicinal Chemistry 2018, 144, 758–766, DOI: 10.1016/j.ejmech.2017.12.057.

21.   Zou, Yi-Hong; Zhao, Liang; Xu, You-Kai; Bao, Jing-Mei; Liu, Xin; Zhang, Jun-Sheng; Li, Wei; Ahmed, Abrar; Yin, Sheng; Tang, Gui-Hua*, Anti-inflammatory sesquiterpenoids from the Traditional Chinese Medicine Salvia plebeia: Regulates pro-inflammatory mediators through inhibition of NF-κB and Erk1/2 signaling pathways in LPS-induced Raw264.7 cells. Journal of Ethnopharmacology 2018, 210, 95–106, DOI: 10.1016/j.jep.2017.08.034.

20.   Chen, Lin; Liu, Bo; Deng, Jun-Jie; Zhang, Jun-Sheng; Li, Wei; Ahmed, Abrar; Yin, Sheng; Tang, Gui-Hua*, Lindera cyclopentenedione intermediates from the roots of Lindera aggregata. RSC Advances 2018, 8, 17898–17904, DOI: 10.1039/C8RA03094D.

19.   Ahmed, Abrar; Li, Wei; Chen, Fang-Fang; Zhang, Jun-Sheng; Tang, Ya-Qi; Chen, Lin; Tang, Gui-Hua*; Yin, Sheng, Monoterpene indole alkaloids from Rhazya stricta. Fitoterapia 2018, 128, 1–6, DOI: 10.1016/j.fitote.2018.04.018.

18.   Ahmed, Abrar; Li, Wei; Zhang, Jun-Sheng; Sam, Pek-Ha; Zou, Yi-Hong; Tang, Gui-Hua*; Yin, Sheng, A new bisabolane sesquiterpenoid and a new abietane diterpenoid from Cephalotaxus sinensis. Natural Product Research 2018, 32, 175–181, DOI: 10.1080/14786419.2017.1343323.

17.   Li, Wei#; Tang, Gui-Hua#; Chen, Lin; Tang, Ya-Qi; Xu, You-Kai; Liu, Bo*; Yin, Sheng*, New pyridocarbazole alkaloids from Strychnos nitida. Natural Product Research 2018, 32, 1532–1536, DOI: 10.1080/14786419.2017.1385016.

16.   Liu, Xin#; Tang, Gui-Hua#; Weng, Han-Zhuang; Zhang, Jun-Sheng; Xu, You-Kai; Yin, Sheng*, A new selaginellin derivative and a new triarylbenzophenone analogue from the whole plant of Selaginella pulvinata. Journal of Asian Natural Products Research 2018, 20, 1123–1128.

15.  Tang, Gui-Hua#; Dong, Zhen#; Guo, Yan-Qiong; Cheng, Zhong-Bin; Zhou, Chu-Jun; Yin, Sheng*, Psiguajadials A–K: Unusual Psidium meroterpenoids as phosphodiesterase-4 inhibitors from the leaves of Psidium guajava. Scientific Reports 2017, 7, 1047–1061, DOI: 10.1038/s41598-017-01028-4.

14.   Li, Wei; Zhang, Jun-Sheng; Huang, Jia-Luo; Jiang, Min-Hong; Xu, You-Kai; Ahmed, Abrar; Yin, Sheng; Tang, Gui-Hua*, New prenylated coumarins from the stems of Toddalia asiatica. RSC Advances 2017, 7, 31061–31068, DOI: 10.1039/C7RA04794K.

13.   Zhang, Jun-Sheng; Huang, Jia-Luo; Zou, Yi-Hong; Liu, Xin; Ahmed, Abrar; Tang, Gui-Hua*; Yin, Sheng, Novel degraded polycyclic polyprenylated acylphloroglucinol and new polyprenylated benzophenone from Hypericum sampsonii. Phytochemistry Letters 2017, 21, 190–193, DOI: 10.1016/j.phytol.2017.06.023.

12.   Sun, Zhang-Hua; Li, Wei; Tang, Gui-Hua*; Yin, Sheng, A new serratene triterpenoid from Lycopodium japonicum. Journal of Asian Natural Products Research 2017, 19, 299–303, DOI: 10.1080/10286020.2016.1208182.

11.   Li, Wei#; Lou, Lan-Lan#; Zhu, Jian-Yong; Zhang, Jun-Sheng; Liang, An-An; Bao, Jing-Mei; Tang, Gui-Hua*; Yin, Sheng, New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense. Fitoterapia 2016, 115, 24–30, DOI: http://dx.doi.org/10.1016/j.fitote.2016.09.010.

10.   Zhang, Jun-Sheng; Zou, Yi-Hong; Zhao, Jing-Jun; Chen, Ye; Bao, Jing-Mei; Tang, Gui-Hua*, Three new diterpenoids from Marrubium aschersonii. Phytochemistry Letters 2016, 16, 241–244, DOI: 10.1016/j.phytol.2016.05.004.

9.     Zou, Yi-Hong; Liu, Xin; Liu, Ye-Na; Tang, Gui-Hua*; Yin, Sheng, A novel heterodimer from Crotalaria ferruginea. Natural Product Communications 2016, 11, 793–794.

8.     Tang, Gui-Hua; Sun, Zhang-Hua; Zou, Yi-Hong; Yin, Sheng*, New cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton ehrenbergi. Molecules 2016, 21, 587–593, DOI: 10.3390/molecules21050587.

7.     Zhu, Jian-Yong; Li, Wei; Bao, Jing-Mei; Zhang, Jun-Sheng; Yin, Sheng; Tang, Gui-Hua*, Diterpenoids from the South China Sea soft coral Sarcophyton solidum. Biochemical Systematics and Ecology 2015, 62, 6–10, DOI: 10.1016/j.bse.2015.07.033.

6.     Tang, Gui-Hua#; Chen, Zi-Wei#; Lin, Ting-Ting; Tan, Min; Gao, Xiao-Yun; Bao, Jing-Mei; Cheng, Zhong-Bin; Sun, Zhang-Hua; Huang, Gang; Yin, Sheng*, Neolignans from Aristolochia fordiana prevent oxidative stress-induced neuronal death through maintaining the Nrf2/HO-1 pathway in HT22 cells. Journal of Natural Products 2015, 78, 1894–1903, DOI: 10.1021/acs.jnatprod.5b00220.

5.     Tang, Gui Hua; Zhang, Yu; Yuan, Chun Mao; Li, Yan; Gu, Yu Cheng; Di, Ying Tong; Wang, Yue Hu; Zuo, Guo Ying; Li, Shi Fei; Li, Shun Lin; He, Hong Ping*; Hao, Xiao Jiang*, Trigohowilols A–G, degraded diterpenoids from the stems of Trigonostemon howii. Journal of Natural Products 2012, 75, 1962–1966, DOI: 10.1021/np3006315.

4.     Tang, Gui Hua; Zhang, Yu; Gu, Yu Cheng; Li, Shi Fei; Di, Ying Tong; Wang, Yue Hu; Yang, Cui Xian; Zuo, Guo Ying; Li, Shun Lin; He, Hong Ping; Hao, Xiao Jiang, Trigoflavidols A–C, degraded diterpenoids with antimicrobial activity, from Trigonostemon flavidus. Journal of Natural Products 2012, 75, 996–1000, DOI: 10.1021/np3001128.

3.     Tang, Gui Hua; He, Hong Ping; Gu, Yu Cheng; Di, Ying Tong; Wang, Yue Hu; Li, Shi Fei; Li, Shun Lin; Zhang, Yu*; Hao, Xiao Jiang*, 3,4-seco-Diterpenoids from Trigonostemon flavidus. Tetrahedron 2012, 68, 9679–9684, DOI: 10.1016/j.tet.2012.09.052.

2.     Tang, Gui Hua; Chen, Dong Mei; Qiu, Bei Ying; Sheng, Li; Wang, Yue Hu; Hu, Guang Wan; Zhao, Fu Wei; Ma, Li Juan; Wang, Huan; Huang, Qiao Qin; Xu, Jin Jin; Long, Chun Lin*; Li, Jia*, Cytotoxic amide alkaloids from Piper boehmeriaefolium. Journal of Natural Products 2011, 74, 45–49, DOI: 10.1021/np100606u.

1.     Tang, Gui Hua; Sun, Chang Song; Long, Chun Lin*; Li, Ma Lin*; Wang, Yue Hu; Luo, Min; Wang, Hong Sheng; Shi, Ya Na, Sesquiterpenoids from Pilea cavaleriei subsp crenata. Bioorganic & Medicinal Chemistry Letters 2009, 19, 5737–5740, DOI: 10.1016/j.bmcl.2009.08.001.

授权专利

2.     尹胜; 黄志纾; 饶勇; 唐贵华; 宋芹芹, 一类惕格烷型二萜化合物及其制备方法和应用. ZL201810522191.6, 2020.04.17 (授权日期).

1.     尹胜; 唐贵华; 张君生; 刘信, 一种天然产物selaginpulvilin的衍生物及其制备方法和应用. ZL201611043917.5, 2020.05.08 (授权日期).