钱宇

简单介绍

钱宇，博士，教授，博士研究生导师。2017年3月通过中山大学“百人计划”二期加入bm11222宝马娱乐网站。主要从事通过设计开发高效合成新技术在抗感染及肿瘤领域进行药物开发与研究。

教育经历

2011-2013， 美国马里兰大学化学与生物化学系，访问学者。

2007-2013， 华东师范大学， 有机化学专业， 博士。

2003-2007， 大连理工大学， 制药工程专业， 学士。

工作经历

2025.04 - 至今，       中山大学，bm11222宝马娱乐网站，教授

2017.11 - 2025.03， 中山大学，bm11222宝马娱乐网站，副教授

2016.07 - 2017.11，华东师范大学，化学与分子工程学院，副研究员

2013.07 - 2016.06， 上海药明康德新药研发有限公司， 国际新药研发部项目组长

教学情况

主讲本科生课程 《大学化学》，《基础化学实验》，《有机化学实验》以及 研究生课程《实用药物合成放大方法与技术》

科研项目

中山大学“百人计划”二期启动项目，主持

广东省科学技术厅，小分子药物发现创新团队，核心成员

“重大新药创制”国家科技重大专项子课题，负责人，

中山大学青年教师培育项目，主持

广东省自然科学基金面上项目，主持

国家自然科学基金青年项目，主持

科技部国家重点研发计划项目，核心成员

广东省重点领域研发计划项目,  核心成员

国家自然科学基金委员会重大研究计划， 核心成员

近期代表性成果

(1) Xiaoyan Yang, Xiaoyu Zhou, Wenhao Hu*, Yu Qian*, “Asymmetric multi-component trifunctionalization reactions with α-Halo Rh-carbenes”, Nature Communications, volume 16, Article number: 1434 (2025).

(2) Mengchu Zhang, Xiaoyan Yang, Xiang Fu, Xiaoyu Zhou, Yu Qian* and Wenhao Hu*, “Chemo- and diastereoselective four-component reactions with Rh carbynoids”, Green Synthesis and Catalysis,2025, 6, 101-105. 

(3) Lisheng Yang, Xinglin Li, Lei Zhao, Wenhao Hu* and Yu Qian*, “Design, synthesis and bioactivity evaluation of novel monomethyl auristatin F analogues”, Molecular Diversity, 2025, 29, 535-550.

(4)  Pei Li, Maoqing Shi, Kaixin Yang, Tongfei Jing, Zhenghui Kang,* Wenhao Hu, and Yu Qian*, Diastereoselective Synthesis of 4‑Hydroxy-2-quinolinones via Formal [2 + 4] Cycloaddition Reactions Using α‑Diazo Pyrazoleamides as C2 Synthons, Org. Lett. 2024, 26, 5554–5559.

(5) Jie Tang, Xiaoyan Yang, Gejun Niu, Tianyuan Zhang, Wenhao Hu* and Yu Qian*, “Rhodium-Catalyzed Formal Four-Component Reaction with Hypervalent Iodine Diazoesters, Alcohols, and Isatins for the Synthesis of Multi-functionalized Oxindoles”, Org. Chem. Front., 2024, 11, 1106–1111. 1

(6) Yu Qian*, Jie Tang, Xiaoyu Zhou, Jian Luo, Xiaoyan Yang, Zhuofeng Ke*, and Wenhao Hu*, “Enantioselective Multifunctionalization with Rh Carbynoids”, J. Am. Chem. Soc. 2023, 145, 26403−26411  

(7) Mengchu Zhang, Tianyuan Zhang, Sifan Yu, Huang Qiu, Abdulla Yusuf, Xinfang Xu, Yu Qian*, Wenhao Hu, “Construction of 4-hydroxycoumarin derivatives with adjacent quaternary and tertiary stereocenters via ternary catalysis”, Chemical Science, 2023,14, 11850-11857.

(8) Maoqing Shi, Gejun Niu, Tianyuan Zhang, Aimin Xu, Rimei Zheng, abdulla yusuf, Taoda Shi, Wenhao Hu and Yu Qian*, “Silver-Catalyzed Pyrazole Migration and Cycloaddition Reaction of Diazo Pyrazoleamides with Ketimines”, Chemical Communications, 2023, 59, 10311–10314

(9) Rimei Zheng; Aimin Xu; Tianyuan Zhang; Pei Li; Maoqing Shi; Shanliang Dong; Wenhao Hu; Yu Qian*, “Asymmetric Acyclic 1,3-Difunctionalization of Vinyl Carbenes via Site-Selective Vinylogous Mannich-Type Interception of Oxonium Ylides”, Org. Lett.2023,25, 5509–5514.

(10) Hongkai Sha, Yu Qian,* Xiangji Yang, Kuiyong Dong, Xinfang Xu and Wenhao Hu, “A copper-catalyzed three-component reaction of dithioacetals with diazo ketones and ketimines” Org. Biomol. Chem., 2022, 20, 8223 – 8227.

(11) Aimin Xu, Xiaoyu Zhou, Rimei Zheng, Zhijing Zhang, Xinru Yin, Kemiao Hong, Zhofeng Ke*, Yu Qian*, Wenhao Hu*, “Chiral rhodium(II)-catalyzed asymmetric aldol-type interception of an oxonium ylide to assemble chiral 2,3-dihydropyrans”, Sci. China Chem.2022,65(8), 1607-1614.

(12) Rimei Zheng, Aimin Xu, Jiawu Huang, Zhijing Zhang, Xinru Yin, Tianyuan Zhang, Wenhao Hu, Yu Qian*, “A Rh(II)-catalyzed highly stereoselective [3 + 2] annulation of vinyl diazoacetates with indole-2-carbaldehyde for the synthesis of indolyl dihydrofurans”, Molecular Diversity, 2022, 26, 3379–3386. (封面文章)

PCT专利：

Wenhao Hu, Fengping Lv, Yang Tang, Ziyan Li, Chen Chen，JianHai Wei，Suzhen Dong，Yu Qian.“SPIRO THREE-MEMBERED RING, SPIRO FIVE-MEMBERED RING PEPTIDE DEFORMYLASE INHIBITOR AND USE THEREOF IN ANTIBACTERIA AND ANTI-TUMOR”专利号：PCT/CN2017/083698

国内发明专利：

• 钱宇; 许爱民; 张芷菁; 郑日梅; 尹鑫茹; 史滔达; 徐新芳; 胡文浩 ; 一种手性二氢吡喃环衍生物及 其制备方法和应用, ZL202110122657.5
• 钱宇; 胡吉迪; 石茂清; 黄佳武; 张芷菁; 史滔达; 徐新芳; 胡文浩 ; 一种芳基酮类肽脱甲酰基酶抑制剂及其在抗菌和抗肿瘤方面的应用,  ZL202110546757.0
• 钱宇; 黄佳武; 石茂清; 张中辉; 张恬源; 胡文浩 ; "一种具有抗肿瘤功效的咪唑类肽脱甲酰基酶抑制剂" ZL202210457993.X
• 钱宇，许爱民，张芷菁，史滔达，郑日梅，尹鑫茹，徐新芳，胡文浩, “一种手性二氢吡喃环衍生物及其制备方法和应用” ZL202110122657.5
• 钱宇，胡吉迪，尹鑫茹，许爱民，杨晓涵，符立梧，徐新芳，胡文浩，“一种吲哚类衍生物及其制备方法和应用” ZL202011134446.5