jin'jing

金晶

副教授

研究领域：1. 中药药理与毒理学研究；2. 靶器官急慢性毒性损伤机制及干预

办公电话： 020-39943034-808

联系邮箱： jinjing@mail.sysu.edu.cn

联系方式

办公电话：020-39943034-808

电子邮箱：jinjing@mail.sysu.edu.cn

办公地址：广州大学城外环东路132号bm11222宝马娱乐网站，510006

简单介绍

金晶，女，博士，bm11222宝马娱乐网站副教授，硕士生、博士生导师。先后于华中科技大学和中山大学获得药学学士、药剂学硕士和药理学博士学位。目前主要从事药理与毒理学的教学与研究工作。近年来，作为项目负责人主持国家自然科学基金4项，以及省市级科研项目8项，作为课题骨干参加国家重点研发计划和重大新药创制等项目。近年来，以第一/通讯作者在国内外重要学术期刊杂志上发表高水平收录论文近50余篇，获国家授权专利2项，实现中药新药专利成果转化1项。任国家自然科学基金同行评审专家；任多种药理与毒理学国际学术期刊特邀审稿人和学术团体委员。

获奖情况：中国药理学会-青年药理学家奖（2016），“广东省特支计划”百千万工程青年拔尖人才（2017），刘昌孝院士人才奖（2018）

（热忱欢迎报读本组硕士、博士研究生，也非常欢迎博士后等优秀科研人员加入）

研究兴趣

1. 中药药理与毒理学研究

2. 靶器官急慢性毒性损伤机制及干预

教育经历

1997年9月-2001年6月   华中科技大学，药学，本科

2001年7月-2004年6月   华中科技大学，药剂学，硕士

2007年9月-2010年6月   中山大学，药理学，博士

工作经历

2004年7月-2010年12月，bm11222宝马娱乐网站，助教

2011年1月-2015年12月，bm11222宝马娱乐网站，讲师

2016年1月-今，bm11222宝马娱乐网站，副教授

科研项目（主持）

1.     国家自然科学基金，面上项目，2023/01-2026/12，项目负责人

2.     国家自然科学基金，面上项目，2020/01-2023/12，项目负责人

3.     国家自然科学基金，面上项目，2016/01-2019/12，项目负责人

4.     国家自然科学基金，青年基金，2012/01-2014/12，项目负责人

5.     广东省自然科学基金，面上项目，2024/01-2026/12，项目负责人

6.     广东省自然科学基金，面上项目，2020/01-2022/12，项目负责人

7.     广东省自然科学基金，面上项目，2021/01-2023/12，项目负责人

8.     广东省科技计划项目，2017/01-2019/12，项目负责人

9.     中山大学青年教师培育计划，2016/01-2018/12，项目负责人

10.   广东省医学科研基金面上项目，2012/6-2015.6，项目负责人

11.   广东省中医药局科研基金面上项目，2015/01-2016/12，项目负责人

12.   横向课题：系列保健产品的毒性评价，2019-2025，项目负责人

社会/学术任职

1. 广东省药理学会药物毒理学专委会  副主任委员

3. 广东省药理学会临床药理专委会  常务委员

4. 广东省药理学会药物代谢专委会  常务委员

2. 中国药理学会表观遗传药理学专业委员会  委员

5. 广东省药理学会药物筛选与评价专委会  委员

6. 广东GLP与药理毒理评价专委会  委员

7. 中国药理学会药物代谢青委会  委员

教学工作

讲授《药物毒理学》、《药学分子生物学》、《生物化学与基础分子生物学实验》、《药代动力学实验》等药学本科课程

参编《药物毒理学》、《生物化学与基础分子生物学实验》、《药代动力学实验》等教材

论著（近年来文章）

  1. Jiang SQ, Nong TL, Yu T, Qin ZY, Huang JY, Yin ZK, Luo SQ, Lai YT, Jin J*, Long term exposure to multiple environmental stressors induces mitochondrial dynamics imbalance in testis: Insights from metabolomics and transcriptomics, Environment International, 2025, 198:109390.

  2. Zeng W, Sun MJ, Cao JM, Chen CX, Jiang SQ, Wang YY, Yang WQ, Zhao ZX*, Jin J*, Triterpenoids from ilicis rotundae cortex ameliorate hyperlipidemia by affecting bile acids-hepatointestinal FXR axis, Phytomedicine, 2025,139:156537.

  3. Cao L, Qin ZY, Yu T, Bai XP, Jiang SQ, Wang DF, Ning FQ, Huang M, Jin J*, Tanshinone IIA acts as a regulator of lipogenesis to overcome osimertinib acquired resistance in lung cancer, Biochemical Pharmacology, 2024, 224:116207. doi: 10.1016/j.bcp.2024.116207

  4. Xu JY, Lu LQ, Jiang SQ, Qin ZY, Huang JY, Huang M, Jin J*, Paeoniflorin ameliorates oxaliplatin-induced peripheral neuropathy via inhibiting neuroinflammation through influence on gut microbiota, European Journal of Pharmacology, 2024, 971:176516. doi: 10.1016/j.ejphar.2024.176516.

  5. Zhang L, Xu CC, Huang JY, Jiang SQ, Qin ZY, Cao L, Tan GY, Zhao ZX, Huang M, Jin J*. Tanshinone IIA reverses gefitinib resistance in EGFR-mutant lung cancer via inhibition of SREBP1-mediated lipogenesis. Phytotherapy Research, 2024, doi: 10.1002/ptr.8130.

  6. Zhang L, Lu LQ, Jiang SQ, Yin ZK, Tan GY, Ning FQ, Qin ZY, Huang JY, Huang M, Jin J*. Salvianolic acid extract prevents Tripterygium wilfordii polyglycosides-induced acute liver injury by modulating bile acid metabolism. Journal of Ethnopharmacology, 2024, 19:117939.

  7. Qin ZY, Song JX, Huang JY, Jiang SQ, Zhang GY, Huang M, Huang ZY, Jin J*, Mitigation of triptolide-induced testicular Sertoli cell damage by melatonin via regulating the crosstalk between SIRT1 and NRF2, Phytomedicine, 2023, 118: 154945.

  8. Qin ZY, Zhang GY, Jiang SQ, Ning FQ, Zhao ZX, Huang M, Jin J*, Integration of metabolomics and transcriptomics to reveal ferroptosis is involved in Tripterygium wilfordii polyglycoside tablet-induced testicular injury, Journal of Ethnopharmacology, 2023, 304:116055.

  9. Zhang L, Jiang SQ, Guan ZH, Huang JY, Yin ZK, Tan GY, Wang YY, Zhao ZX, Huang M, Jin J*, Effect of Salvia miltiorrhiza Bunge extracts on improving the efficacy and reducing the toxicity of Tripterygium wilfordii polyglycosides in the treatment of rheumatoid arthritis, Journal of Ethnopharmacology, 2023, 317:116785.

  10. Tan GY, Qin ZY, Jiang SQ, Zhang L, Zhang GY, Huang M, Huang ZY, Jin J*, MitoQ alleviates triptolide-induced cardiotoxicity via activation of p62/Nrf2 axis in H9c2 cells, Toxicology in Vitro, 2023, 86:105487.

  11. Chen J, Cao D, Jiang SQ, Liu X, Pan WC, Cui H, YangWQ, Liu ZQ, Jin J*, Zhao ZX*, Triterpenoid saponins from Ilex pubescens promote blood circulation in blood stasis syndrome by regulating sphingolipid metabolism and the PI3K/AKT/eNOS signaling pathway, Phytomedicine, 2022, 104:154242.

  12. Xu CC, Zhang L, Wang DF, Jiang SQ, Cao D, Zhao ZX, Jin J*, Lipidomics reveals that sustained SREBP-1-dependent lipogenesis is a key mediator of gefitinib-acquired resistance in EGFR-mutant lung cancer, Cell Death Discovery, 2021, 7:353.

  13. Jiang SQ, Shen XT, Xuan SX, Yang B, Ruan QF, Cui H, Zhao ZX*, Jin J*, Serum and colon metabolomics study reveals the anti-ulcerative colitis effect of Croton crassifolius Geisel, Phytomedicine, 2021, 87:153570.

  14. Cao L, Hong WP, Xu CC, Bai XP, Zhao ZX, Huang M, Jin J*. Cryptotanshinone strengthens the effect of gefitinib against non-small cell lung cancer through inhibiting transketolase, European Journal of Pharmacology, 2021, 890:173647.

  15. Yang B, Xuan SX, Ruan QF, Jiang SQ, Cui H, Zhu LP, Luo X, Jin J*, Zhao ZX*. UPLC/Q-TOF-MS/MS-based metabolomics revealed the lipid-lowering effect of Ilicis Rotundae Cortex on high-fat diet induced hyperlipidemia rats. Journal of Ethnopharmacology, 2020,256: 112784.

  16. Wang DF, Yu WB, Cao L, Xu CC, Tan GY, Zhao ZX, Huang M*, Jin J*, Comparative pharmacokinetics and tissue distribution of cryptotanshinone, tanshinone IIA, dihydrotanshinone I, and tanshinone I after oral administration of pure tanshinones and liposoluble extract of Salvia miltiorrhiza to rats, Biopharmceutics & Drug Disposition, 2020, 41(1-2):54-63.

  17. Chen YB, Zhou ZY, Li GM, Xiao CX, Yu WB, Zhong SL*, Cai YF*, Jin J*, Huang M, Influences of an NR1I2 polymorphism on heterogeneous antiplatelet reactivity responses to clopidogrel and clinical outcomes in acute ischemic stroke patients, Acta Pharmacologica Sinica, 2019, 40(6):762-768.

  18. Yu WB, Xu CC, Li GM, Hong WP, Zhou ZY, Xiao CX, Zhao YQ, Cai YF, Huang M, Jin J*. Simultaneous determination of trimethylamine N-oxide, choline, betaine by UPLC-MS/MS in human plasma: An application in acute stroke patients. Journal of Pharmaceutical and Biomedical Analysis, 2018, 152(4): 179-187.

  19. Cao D, Xu CC, Xue YY, Ruan QF, Yang B, Liu ZQ, Cui H, Zhang L, Zhao ZX*, Jin J*. The therapeutic effect of Ilex pubescens extract on blood stasis model rats according to serum metabolomics. Journal of Ethnopharmacology, 2018,227:18-28.

  20. Hong WP, Cai PH, Xu CC, Cao D, Yu WB, Zhao ZX, Huang M, Jin J*, Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System. Frontiers in Pharmacology, 2018, 9:43.

  21. Bai XP, Hong WP, Cai PH, Chen YB, Xu CC, Cao D, Yu WB, Zhao ZX, Huang M, Jin J*. Valproate induced hepatic steatosis by enhanced fatty acid uptake and triglyceride synthesis. Toxicology and Applied Pharmacology, 2017, 324(6): 12-25.

  22. Bai XP, Chen YB, Hou XY, Huang M*, Jin J*. Emerging role of NRF2 in chemoresistance by regulating drug-metabolizing enzymes and efflux transporters. Drug Metabolism Reviews. 2016, 48(4):541-567.

  23. Chen XM, Zhao ZX, Chen YB, Gou XL, Zhou ZY, Zhong GP, Cai YF, Huang M, Jin J*. Mechanistic understanding of the effect of Dengzhan Shengmai capsule on the pharmacokinetics of clopidogrel in rats. Journal of Ethnopharmacology. 2016, 192:362-369.

  24. Hou XY, Bai XP, Gou XL, Zeng H, Xia C, Zhuang W, Chen XM, Zhao ZX, Huang M, Jin J*. 3',4',5',5,7-Pentamethoxyflavone sensitizes cisplatin-resistant A549 cells to cisplatin by inhibition of Nrf2 pathway, Molecules and Cells, 2015, 38(5): 396-401.

  25. Jin J, Sun XZ, Zhao ZX, Wang WW, Qiu YW, Fu XL, Huang M, Huang ZY*. Activation of the farnesoid X receptor attenuates triptolide-induced liver toxicity. Phytomedicine, 2015, 22(10):894-901.

  26. Jin J, Li M., Wang WW, Sun XZ, Li J, Zhao ZX, Huang M, Huang ZY*. Protective effect of Wuzhi tablet (Schisandra sphenanthera extract) against cisplatin-induced nephrotoxicity via Nrf2-mediated defense response. Phytomedicine, 2015, 22(5):528-535.

  27. Wang WW, Guan CW, Sun XZ, Zhao ZX, Li J, Fu XL, Qiu YW, Huang M, Jin J*, Huang ZY*. Tanshinone IIA protects against acetaminophen-induced hepatotoxicity via activating the Nrf2 pathway. Phytomedicine, 2016，23：589-596.