黄世亮

2025年招收专硕2名，欢迎报考，联系方式lsshsl@mail.sysu.edu.cn

简单介绍

黄世亮，1973年，博士，博导，副教授。1995年于沈阳药科大学获得化学制药专业学士学位，并于1998年获该校药物化学硕士学位，2006年于中山大学获有机化学博士学位。1998年在中山大学任教至今。2010-2011年国家公派英国诺丁汉大学bm11222宝马娱乐网站访问学者。

科研项目

1）热休克转录因子HSF1选择性抑制剂的设计、合成及抗肿瘤作用机制研究，国家自然科学基金面上项目（82073680），2021.1-2024.12

2)  以阿的平为先导化合物的Hsp90/Topo II双靶点抑制剂的结构改造、活性筛选与机制研究（2021A1515010554），2021.1-2023.12

3)  选择性靶向Top IIa的ATPase的新型抗肿瘤曼宋酮类化合物的设计、合成及机制研究(21272288/B020601),国家自然科学基金，2013.1-2016.12.

4）基于FP和TR-FRET高通量筛选技术：靶向Top IIa ATPase新先导物的发现及结构改造（2015A030313120）,省自然科学基金面上项目，2014年10月至 2017年9月

5）选择性靶向Top IIα的ATPase的新型抗肿瘤曼宋酮类化合物的设计、合成及机制研究(21272288), 国家自然科学基金，2013.1-2016.12.

6） 靶向TopIIα ATPase位点的新型曼宋酮类化合物的设计、合成及机制研究,药用资源化学与药物分子工程教育部重点实验室资助课题（CMEMR2012-B02）, 2012.6-2015.5

论著专利

1) Xu, S. M.; Wang, L.; Liu, X. Z.; Huang, W. H.; Hu, Y. T.; Chen, S. B.; Huang, Z. S.*; Huang, S. L*. Synergistic anticancer activity of HSP70 and HSF1 inhibitors in colorectal cancer cells: A new strategy for combination therapy. Biochim Biophys Acta Mol Basis Dis 2024, 167630

2) Ou, J. B.; Huang, W. H.; Liu, X. Z.; Dai, G. Y.; Wang, L.; Huang, Z. S.; Huang, S. L.* MSN8C: A Promising Candidate for Antitumor Applications as a Novel Catalytic Inhibitor of Topoisomerase II. Molecules2023, 28(14), 5598-5605.

3) Pan, X.; Mao, T.-y.; Mai, Y.-w.; Liang, C.-c.; Huang, W.-h.; Rao, Y.; Huang, Z.-s.; Huang, S.-l.* Discovery of Quinacrine as a Potent Topo II and Hsp90 Dual-Target Inhibitor, Repurposing for Cancer Therapy. Molecules2022, 27.5561-5577.

4)  Mai, Y.-W.; Liang, C.-C.; Ou, J.-B.; Xie, H.-T.; Chen, S.-B.; Zhou, D.-C.; Yao, P.-F.; Huang, Z.-S.; Wang, H.; Huang, S.-L.* 9-Bromo-2,3-diethylbenzo[de]chromene-7,8-dione (MSN54): A novel non-intercalative topoisomerase II catalytic inhibitor. Bioorganic Chemistry2021, 114.105097

5) Zhou, M.; Wang, X.; Xia, J.; Cheng, Y.; Xiao, L.; Bei, Y.; Tang, J.; Huang, Y.; Xiang, Q.*; Huang, S.* A Mansonone Derivative Coupled with Monoclonal Antibody 4D5-Modified Chitosan Inhibit AKR1C3 to Treat Castration-Resistant Prostate Cancer. Int J Nanomedicine2020, 15, 3087-3098.

6) Zhou, D. C.; Lu, Y. T.; Mai, Y. W.; Zhang, C.; Xia, J.; Yao, P. F.; Wang, H. G.; Huang, S. L.*; Huang, Z. S.*，Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors. Bioorg Chem2019, 91, 103131.

7) Peng Lv, Chun-Li Xia, Ning Wang, Zhen-Quan Liu, Zhi-Shu Huang, Shi-Liang Huang. Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation. Bioorg Med Chem, 2018, 26(16), 4693-4705

8）Xie, H.-T.; Zhou, D.-C.; Mai, Y.-W.; Huo, L.; Yao, P.-F.; Huang, S.-L.*; Wang, H.-G.; Huang, Z.-S.; Gu, L.-Q. Construction of the oxaphenalene skeletons of mansonone F derivatives through C–H bond functionalization and their evaluation for anti-proliferative activities. RSC Adv. 2017, 7, 20919-20928.

9）Li, P. H.; Zeng, P.; Chen, S. B.; Yao, P. F.; Mai, Y. W.; Tan, J. H.; Ou, T. M.; Huang, S. L.*; Li, D.; Gu, L. Q.; Huang, Z. S.*Synthesis and Mechanism Studies of 1,3-Benzoazolyl Substituted Pyrrolo[2,3-b]pyrazine Derivatives as Nonintercalative Topoisomerase II Catalytic Inhibitors. J Med. Chem. 2016, 59, 238-52.

10）Zhai, P.; Xia, C. L.; Tan, J. H.; Li, D.; Ou, T. M.; Huang, S. L.*; Gu, L. Q.; Huang, Z. S.* Syntheses and evaluation of asymmetric curcumin analogues as potential multifunctional agents for the treatment of Alzheimer's disease. Current Alzheimer research2015, 12, 403-14.

11） Yao, B. L.; Mai, Y. W.; Chen, S. B.; Xie, H. T.; Yao, P. F.; Ou, T. M.; Tan, J. H.; Wang, H. G.; Li, D.; Huang, S. L.*; Gu, L. Q.; Huang, Z. S.* Design, synthesis and biological evaluation of novel 7-alkylamino substituted benzo[a]phenazin derivatives as dual topoisomerase I/II inhibitors. Eur. J. Med. Chem.2015, 92, 540-53.   

12）Zhuo, S. T., Li, C. Y., Hu, M. H., Chen, S. B., Yao, P. F., Huang, S. L.,* Ou, T. M., Tan, J. H., An, L. K., Li, D., Gu, L. Q., and Huang, Z. S.* Synthesis and biological evaluation of benzo[a]phenazine derivatives as a dual inhibitor of topoisomerase I and II, Org. Biomol. Chem.2013,11(24), 3989-4005.

13)   Huang, Z. H., Zhuo, S. T., Li, C. Y., Xie, H. T., Li, D., Tan, J. H., Ou, T. M., Huang, Z. S., Gu, L. Q., and Huang, S. L.* Design, synthesis and biological evaluation of novel mansonone E derivatives prepared via CuAAC click chemistry as topoisomerase II inhibitors, Eur. J. Med. Chem. 2013,68C, 58-71.

14)   Chen, Y. P., Zhang, Z. Y., Li, Y. P., Li, D., Huang, S. L.,* Gu, L. Q., Xu, J., and Huang, Z. S. () Syntheses and evaluation of novel isoliquiritigenin derivatives as potential dual inhibitors for amyloid-beta aggregation and 5-lipoxygenase, Eur. J. Med. Chem. 2013, 66, 22-31.

15)   Li, Y. P., Weng, X., Ning, F. X., Ou, J. B., Hou, J. Q., Luo, H. B.,* Li, D., Huang, Z. S., Huang, S. L.,* and Gu, L. Q. 3D-QSAR studies of azaoxoisoaporphine, oxoaporphine, and oxoisoaporphine derivatives as anti-AChE and anti-AD agents by the CoMFA method, J. Mol. Graph. Model.2013, 41, 61-67.

16)   Li, Y.-P., Ning, F.-X., Yang, M.-B., Li, Y.-C., Nie, M.-H., Ou, T.-M., Tan, J.-H., Huang, S.-L.,* Li, D., Gu, L.-Q., Huang, Z.-S. Syntheses and characterization of novel oxoisoaporphine derivatives as dual inhibitors for cholinesterases and amyloid beta aggregation. Eur. J. Med. Chem., 2011. 46(5): 1572-1581

17)    Fang Xian Ning, Xiang Weng, Shi Liang Huang,* Li Jun Gu, Zhi Shu Huang, * Lian Quan Gu.A facile and efficient method for hydroxylation of azabenzanthrone compounds.Chin. Chem. Lett.2011,22(1), 41-44

18)   Wei-bin Wu, Jie-bin Ou, Zhi-shu Huang, Shuo-bin Chen, Tian-miao Ou, Jia-heng. Tan, Ding Li, Liu-lan. Shen, Shi-liang Huang*, Lian-quan Gu and Zhi-shu Huang, Eur. J. Med. Chem.2011, 46, 3339-3347.

19)   Zhong Liu, Shi-Liang Huang, Man-Mei Li, Zhi-Shu Huang, Kin Sing Lee*, Lian-Quan Gu*. Inhibition of thioredoxin reductase by mansonone F analogues: Implications for anticancer activity. Chem-Bio. Interac.2009, 177(1), 48-57

20)   Hua-pei Jian, Xing-yuan Wang, Zhi-shu Huang, Shi-liang Huang,*, Lian-quan Gu. A Facile Synthesis of Novel Heteropolycyclic Pyrazines and Oxazoles Mechanistic Studies of 2,3-Dihydrobenzo[de]chromene-7,8-dione with Amines. Heterocycles.2008,75(7),1773-1778.