陈硕斌
副教授
研究领域：以G-四链体及其解旋酶为靶点的药物化学与化学生物学
办公电话： 020-39943072
联系邮箱： chenshb8@mail.sysu.edu.cn
基本介绍：
陈硕斌，男，博士，副教授，博士生导师。
研究方向：以G-四链体及其解旋酶为靶点的药物化学与化学生物学。
科研情况：主持8项科研项目，包括国家自然科学基金项目面上与青年项目、广东省自然科学杰出青年基金、广州市科技计划项目珠江科技新星专题等； 发表高水平论文50多篇，其中近五年以一作/通讯作者身份在J. Am. Chem. Soc.、Angew. Chem. Int. Ed.、Adv. Sci.、J. Med. Chem.、Nucleic Acid Res. 等国际权威期刊上发表高水平论文十数篇；担任J. Med. Chem.、Eur. J. Med. Chem.等杂志的审稿人。此外获授权中国专利10项。
教学情况：参与本科一流课程《生物化学》、《生物化学与基础分子生物学实验》等教学；参与研究生课程《生物有机化学》、《计算模拟在药学研究中的应用》等教学。
2025年招生计划：招学硕1名（邮件联系 chenshb8@mail.sysu.edu.cn）
教育与工作经历：
2007.09-2011.06 bm11222宝马娱乐网站，药学专业，获学士学位
2011.09-2016.06 bm11222宝马娱乐网站，药物化学专业，获博士学位
2016.07-2019.04 bm11222宝马娱乐网站，副研究员
2019.05-至今 bm11222宝马娱乐网站，副教授
主持省部级科研项目：
1. 国家自然科学基金—面上项目（2024年）：WRN解旋酶特异性变构抑制剂的发现及其在“化学合成致死”上的作用机制研究；
2. 国家自然科学基金—面上项目（2020年）：靶向G-四链体解旋酶DHX36新型c-MYC转录抑制剂的发现及其作用机制研究；
3. 广东省自然科学基金—杰出青年项目（2019年）：以RecQ家族G-四链体解旋酶为新靶点的药物化学研究；
4. 国家自然科学基金—青年项目（2018年）：基于癌基因NRAS 翻译调控的抗黑色素瘤先导化合物发现及作用机制研究；
5. 广州市科技计划项目珠江科技新星专题（2019年）：新型癌基因NRAS 翻译抑制剂的快速筛选与抗癌活性研究；
6. 广东省自然科学基金-自由申请项目（2017年）：c-myc 启动子G-四链体荧光杂交探针的设计合成及其在转录调控研究中的应用。
近年代表性论著（中科院1区）：
[1] Zhang, K.#; Nie, Q.#; Li, M.#; Chen, X.; Zhong, L.; Dai, T.; Guo, X.; Zhao, H.; Lau, T. C.-K.; Wang, H.; Chen, S.-B.*; Kwok, C. K.*, RNA G-quadruplex structure-based PROTACs for targeted DHX36 protein degradation and gene activity modulation in mammalian cells. Nucleic acids Res.2025, 53 (3), doi:10.1093/nar/gkaf039.
[2] Ning, K.#; Tang, X.; Li, Z.; Zhong, L.; Zhou, Y.; Wang, J.; Huang, W.; Zhang, H.; Ke, J.; Luan, T.*; Chen, S.-B.*; Zhai, J.*, Specific Monitoring the DNA Helicase Function via Anchor-Embedded DNA Probe. Adv. Sci.2024, n/a (n/a), 2413368.
[3] Jiang, Z.; Hu, Y.-T.; Guo, S.-Y.; Li, Y.-X.; Zhao, D.-D.; Wei, L.-Y.; Lin, Y.-W.; Xu, S.-M.; Huang, S.-L.; Li, Q.; Tan, J.-H.; Rao, Y.; Chen, S.-B.; Huang, Z.-S., Development of Novel N-Acylhydrazone Derivatives with High Anti-obesity Activity and Improved Safety by Exploring the Pharmaceutical Properties of Aldehyde Group. Journal of medicinal chemistry 2024, 67 (14), 12439-12458.
[4] Li, M.-L.#; Dai, L.-T.; Gao, Z.-Y.; Yan, J.-T.; Xu, S.-M.; Tan, J.-H.; Huang, Z.-S.; Chen, S.-B.*; Chen, X.-C.*, Discovery of Novel Coumarin-quinolinium Derivatives as Pan-KRAS Translation Inhibitors by Targeting 5'-UTR RNA G-Quadruplexes. J. Med. Chem.2024, 67 (3), 1961-1981.
[5] Cai, J.-H.#; Yang, D.-Y.#; Zhang, J.-J.; Tan, J.-H.; Huang, Z.-S.*; Chen, S.-B.*, Constructing triazole-modified quinazoline derivatives as selective c-MYC G-quadruplex ligands and potent anticancer agents through click chemistry. Bioorg. Chem.2024, 144, 107173.
[6] Xu, Y.-H.#; Hu, Y.-T.#; Xu, S.-M.; Song, B.-B.; Yuan, H.; Zhao, D.-D.; Guo, S.-Y.; Jiang, Z.; Wei, L.-Y.; Rao, Y.; Tan, J.-H.; Huang, S.-L.; Li, Q.-J.; Chen, S.-B.*; Huang, Z.-S.*, Design and Synthesis of Bouchardatine Derivatives as a Novel AMP-Activated Protein Kinase Activator for the Treatment of Colorectal Cancer. J. Med. Chem.2023, 66 (11), 7387-7404.
[7] Chen, X.-C.#; Tang, G.-X.#; Dai, J.#; Dai, L.-T.; Wu, T.-Y.; Li, W.-W.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.*; Chen, S.-B.*, Discovery of Clinically Used Octenidine as NRAS Repressor That Effectively Inhibits NRAS-Mutant Melanoma. J. Med. Chem.2023, 66 (7), 5171-5184.
[8] Yuan, J.-H.#; Tu, J.-L.; Liu, G.-C.; Chen, X.-C.; Huang, Z.-S.; Chen, S.-B.*; Tan, J.-H.*, Visualization of ligand-induced c-MYC duplex–quadruplex transition and direct exploration of the altered c-MYC DNA-protein interactions in cells. Nucleic Acids Res.2022, 50(8), 4246-4257.
[9] Li, M.-L.#; Yuan, J.-M.#; Yuan, H.; Wu, B.-H.; Huang, S.-L.; Li, Q.-J.; Ou, T.-M.; Wang, H.-G.; Tan, J.-H.; Li, D.; Chen, S.-B.*; Huang, Z.-S.*, Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex. J. Med. Chem.2022, 65, 12675.
[10] Jiang, X.-C.#; Tu, F.-H.#; Wei, L.-Y.; Wang, B.-Z.; Yuan, H.; Yuan, J.-M.; Rao, Y.; Huang, S.-L.; Li, Q.-J.; Ou, T.-M.; Wang, H.-G.; Tan, J.-H.; Chen, S.-B.*; Huang, Z.-S.*, Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer. J. Med. Chem.2022, 65, 12346.
[11] Yu, Z.-Y.#; Luo, W.-H.#; Wang, J.-E.; Diao, H.-J.; Wu, T.-Y.; Zeng, S.-T.; Chen, X.-C.; Huang, Z.-S.; Tan, J.-H.; Chen, S.-B.*, Dual-color imaging of DNA and RNA simultaneously with an aggregation/monomer-based deep-red fluorescent probe. Sens. Actuators. B Chem. 2022, 361, 131730.
[12] Chen, X.-C.#; Tang, G.-X.; Luo, W.-H.; Shao, W.; Dai, J.; Zeng, S.-T.; Huang, Z.-S.; Chen, S.-B.*; Tan, J.-H.*, Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis. J. Am. Chem. Soc.2021, 143 (49), 20779-20791.
[13] Wang, C.-X.#; Zhang, Z.-L.; Yin, Q.-K.; Tu, J.-L.; Wang, J.-E.; Xu, Y.-H.; Rao, Y.; Ou, T.-M.; Huang, S.-L.; Li, D.; Wang, H.-G.; Li, Q.-J.; Tan, J.-H.; Chen, S.-B.*; Huang, Z.-S.*, Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors. J. Med. Chem. 2020, 63 (17), 9752-9772.
[14] Yin, Q.-K.#; Wang, C.-X.; Wang, Y.-Q.; Guo, Q.-L.; Zhang, Z.-L.; Ou, T.-M.; Huang, S.-L.; Li, D.; Wang, H.; Tan, J.-H.; Chen, S.-B.*; Huang, Z.-S.*, Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors that Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J. Med. Chem.2019, 62 (6), 3147-3162.
[15] Huang, Z.-L.#; Dai, J.#; Luo, W.-H.; Wang, X.-G.; Tan, J.-H.; Chen, S.-B.*; Huang, Z.-S.*, Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions. J. Am. Chem. Soc. 2018,140 (51), 17945-17955.
[16] Chen, X.-C.#; Chen, S.-B.#; Dai, J.; Yuan, J.-H.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.*, Tracking the Dynamic Folding and Unfolding of RNA G-Quadruplexes in Live Cells. Angew. Chem. Int. Ed. Engl. 2018,57 (17), 4702-4706.
[17] Hu, M.-H.#; Wang, Y.-Q.#; Yu, Z.-Y.; Hu, L.-N.; Ou, T.-M.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.*, Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex. J. Med. Chem. 2018,61 (6), 2447-2459.
[18] Wang, Y.-Q.#; Hu, M.-H.#; Guo, R.-J.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.*, Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA. Sens. Actuators. B Chem. 2018,266, 187-194.
[19] Chen, S.-B.#; Hu, M.-H.; Liu, G.-C.; Wang, J.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.*; Tan, J.-H.*, Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe. J. Am. Chem. Soc. 2016,138 (33), 10382-10385.
[6] Yuan, J.-H.#; Tu, J.-L.; Liu, G.-C.; Chen, X.-C.; Huang, Z.-S.; Chen, S.-B.*; Tan, J.-H.*, Visualization of ligand-induced c-MYC duplex–quadruplex transition and direct exploration of the altered c-MYC DNA-protein interactions in cells. Nucleic Acids Res. 2022, 50(8), 4246-4257.
[7] Li, M.-L.#; Yuan, J.-M.#; Yuan, H.; Wu, B.-H.; Huang, S.-L.; Li, Q.-J.; Ou, T.-M.; Wang, H.-G.; Tan, J.-H.; Li, D.; Chen, S.-B.*; Huang, Z.-S.*, Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex. J. Med. Chem. 2022, 65, 12675.
[8] Jiang, X.-C.#; Tu, F.-H.#; Wei, L.-Y.; Wang, B.-Z.; Yuan, H.; Yuan, J.-M.; Rao, Y.; Huang, S.-L.; Li, Q.-J.; Ou, T.-M.; Wang, H.-G.; Tan, J.-H.; Chen, S.-B.*; Huang, Z.-S.*, Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer. J. Med. Chem. 2022, 65, 12346.
[9] Tu, J.-L.#; Wu, B.-H.#; Wu, H.-B.; Wang, J.-E.; Zhang, Z.-L.; Gao, K.-Y.; Zhang, L.-X.; Chen, Q.-R.; Zhou, Y.-C.; Tan, J.-H.; Huang, Z.-S.; Chen, S.-B.*, Design, synthesis and evaluation of N3-substituted quinazolinone derivatives as potential Bloom's Syndrome protein (BLM) helicase inhibitor for sensitization treatment of colorectal cancer. Eur. J. Med. Chem. 2022, 246, 114944.
[10] Yu, Z.-Y.#; Luo, W.-H.#; Wang, J.-E.; Diao, H.-J.; Wu, T.-Y.; Zeng, S.-T.; Chen, X.-C.; Huang, Z.-S.; Tan, J.-H.; Chen, S.-B.*, Dual-color imaging of DNA and RNA simultaneously with an aggregation/monomer-based deep-red fluorescent probe. Sens. Actuators. B Chem. 2022, 361, 131730.
[11] Chen, X.-C.#; Tang, G.-X.; Luo, W.-H.; Shao, W.; Dai, J.; Zeng, S.-T.; Huang, Z.-S.; Chen, S.-B.*; Tan, J.-H.*, Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis. J. Am. Chem. Soc. 2021, 143 (49), 20779-20791.
[12] Wang, C.-X.#; Zhang, Z.-L.; Yin, Q.-K.; Tu, J.-L.; Wang, J.-E.; Xu, Y.-H.; Rao, Y.; Ou, T.-M.; Huang, S.-L.; Li, D.; Wang, H.-G.; Li, Q.-J.; Tan, J.-H.; Chen, S.-B.*; Huang, Z.-S.*, Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors. J. Med. Chem. 2020, 63 (17), 9752-9772.
[13] Yin, Q.-K.#; Wang, C.-X.; Wang, Y.-Q.; Guo, Q.-L.; Zhang, Z.-L.; Ou, T.-M.; Huang, S.-L.; Li, D.; Wang, H.; Tan, J.-H.; Chen, S.-B.*; Huang, Z.-S.*, Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors that Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. J. Med. Chem. 2019, 62 (6), 3147-3162.
[14] Huang, Z.-L.#; Dai, J.#; Luo, W.-H.; Wang, X.-G.; Tan, J.-H.; Chen, S.-B.*; Huang, Z.-S.*, Identification of G-Quadruplex-Binding Protein from the Exploration of RGG Motif/G-Quadruplex Interactions. J. Am. Chem. Soc. 2018, 140 (51), 17945-17955.
[15] Chen, X.-C.#; Chen, S.-B.#; Dai, J.; Yuan, J.-H.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.*, Tracking the Dynamic Folding and Unfolding of RNA G-Quadruplexes in Live Cells. Angew. Chem. Int. Ed. Engl. 2018, 57 (17), 4702-4706.
[16] Hu, M.-H.#; Wang, Y.-Q.#; Yu, Z.-Y.; Hu, L.-N.; Ou, T.-M.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.*, Discovery of a New Four-Leaf Clover-Like Ligand as a Potent c-MYC Transcription Inhibitor Specifically Targeting the Promoter G-Quadruplex. J. Med. Chem. 2018, 61 (6), 2447-2459.
[17] Wang, Y.-Q.#; Hu, M.-H.#; Guo, R.-J.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.*, Tuning the selectivity of a commercial cyanine nucleic acid dye for preferential sensing of hybrid telomeric G-quadruplex DNA. Sens. Actuators. B Chem. 2018, 266, 187-194.
[18] Chen, S.-B.#; Hu, M.-H.; Liu, G.-C.; Wang, J.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.*; Tan, J.-H.*, Visualization of NRAS RNA G-Quadruplex Structures in Cells with an Engineered Fluorogenic Hybridization Probe. J. Am. Chem. Soc. 2016, 138 (33), 10382-10385.
