邹滔滔

邹滔滔

教授

研究领域：金属药物化学和化学生物学领域，尤其是基于小分子的抗癌药物和肿瘤发光探针，包括抗癌药物的设计合成及其抗肿瘤活性研究、光亲和标记-点击化学相结合的分子靶点识别方法、核酸多级结构探针、药物可控释放等。

办公电话： 39943040（bm11222宝马娱乐网站408办公室）

联系邮箱： zoutt3@mail.sysu.edu.cn

个人主页： https://ttzouchem.wixsite.com/zoulab

简单介绍

邹滔滔，博士，中山大学教授、博士生导师，国家优秀青年基金获得者，广东省“珠江人才计划”青年拔尖人才，中山大学“百人计划”中青年杰出人才。本科毕业于武汉大学化学学院（导师：杨楚罗教授），博士毕业于香港大学化学系（导师：支志明院士），并在Scripps研究所（导师：Xiang-Lei Yang教授、Paul Schimmel教授)、香港大学（导师：支志明教授）、华威大学（导师Peter J Sadler教授）从事博士后研究工作，研究方向为药物化学生物学和生物无机化学，长期致力于开发含金属药物，近期研究方向集中在设计新型抗癌前体药物和发展具有抗癌免疫活性的小分子药物等领域，并以通讯作者在Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Coord. Chem. Rev.等期刊发表多篇论文。担任《Science Bulletin》和《科学通报》特邀编委。

ORCID: https://orcid.org/0000-0001-9129-4398

Researcher ID: G-2044-2018 

招生招聘信息

  1. 课题组长期招聘具有化学生物学、药物化学、生物无机背景，对抗癌药物感兴趣的博士后和专职科研人员，提供优厚待遇。
  2. 欢迎报考本课题组硕士研究生、博士研究生。
  3. 欢迎对药物化学生物学感兴趣的本科生到实验室交流学习。

所获荣誉

  • 2021年  国家自然科学基金“优秀青年科学基金”
  • 2020年  AsBIC Graeme Hanson Early Career Award (亚洲生物无机化学学会青年科学家奖)
  • 2019年 “珠江人才计划”引进青年拔尖人才
  • 2019年  深圳市自然科学一等奖（排名第五）
  • 2016年  CAS/SciFinder Future Leaders
  • 2015年  Reaxys PhD Prize (Finalist)
  • 2015年  Springer Theses Prize
  • 2015年  Li Ka Shing Prize
  • 2014年  Hong Kong Young Scientist Award（winner） 

Selected publications

  1. Liu, M.; Liu, H.; Yang, Y.; Xiong, X.*; Zou, T.* "Subcellular Photocatalysis Enables Tumor-Targeted Inhibition of Thioredoxin Reductase I by Organogold(I) Complexes", J. Am. Chem. Soc., 2025, doi: 10.1021/jacs.5c03186.

  2. Lu, Y.; Wang, F.-Y.; Levine, M. S.; Shi, H.-R.; Wang, Y.; Xiong, X.; Yang, L.-M.; Shi, Y.-Q.; Zou, T.*; Sessler J. L.*; Liang, H.*; Huang, K,-B.*, "Oxoisoaporphine Alkaloid Iridium(III) Derivative: An Immunogenic Cell Death Inducer that Engages the Autophagy-Dependent Regulator Cathepsin D." J. Am. Chem. Soc.2025, doi: 10.1021/jacs.5c00255.

  3. Xie, Z.†; Cao, B.†; Zhao,†; Liu, M.†; Lao, Y.; Luo, H.; Zhong, Z.; Xiong, X.; Wei, W.*; Zou, T.* "Ion Pairing Enables Targeted Prodrug Activation via Red Light Photocatalysis: A Proof-of-Concept Study with Anticancer Gold Complexes." J. Am. Chem. Soc.2024, 146, 8547-8556.

  4. Huang, K.-B.*; Wang, F.-Y.; Lu, Y.; Yang, L.-M.; Long, N.; Wang, S.-S.; Xie, Z.; Levine, M.; Zou, T.*; Sessler, J. L.*; Liang, H.* "Cu(II) complex that synergistically potentiates cytotoxicity and an antitumor immune response by targeting cellular redox homeostasis." Proc. Natl. Acad. Sci.2024, 121, e2404668121.

  5. Liu, M.; Luo, Y.; Yan, J.; Xiong, X.; Xing, X.*; Kim, J. S.*; Zou, T.* "Photoactivation of Boronic Acid Prodrugs via a Phenyl Radical Mechanism: Iridium(III) Anticancer Complex as an Example." J. Am. Chem. Soc.2023, 145, 10082-10091.

  6. Jiang, J.†; Xiong, X.†; Zou, T.* "Modulating the Chemical Reactivity of Gold Complexes in Living Systems: From Concept to Biomedical Applications." Acc. Chem. Res. 2023, 56, 1043-1056.

  7. Luo, Y.; Cao, B.; Zhong, M.; Liu, M.; Xiong, X.; Zou, T.*, "Organogold(III) Complexes Display Conditional Photoactivities: Evolving From Photodynamic into Photoactivated Chemotherapy in Response to O2 Consumption for Robust Cancer Therapy." Angew. Chem. Int. Ed. 2022, 61 e202212689.

  8. Xiong, X.†; Huang, K.-B.†; Wang, Y.†; Cao, B.; Luo, Y.; Chen, H.; Yang, Y.; Long, Y.; Liu, M.; Chan, A. S. C.; Liang, H.*; Zou, T.*, "Target Profiling of an Iridium(III)-based Immunogenic Cell Death Inducer Unveils the Engagement of Unfolded Protein Response Regulator BiP." J. Am. Chem. Soc.2022, 144, 10407-10416..

  9. Jiang, J.†; Cao, B.†; Chen, Y.†; Luo, H.; Xue, J.; Xiong, X.; Zou, T.*, "Alkylgold(III) Complexes Undergo Unprecedented Photo-Induced β-Hydride Elimination and Reduction for Targeted Cancer Therapy."Angew. Chem. Int. Ed.2022, 61, e202201103.

  10. Xiong, X.; Liu, L.-Y.; Mao, Z.-W.*; Zou, T.* "Approaches towards understanding the mechanism-of-action of metallodrugs." Coord. Chem. Rev.2022, 453, 214311.

  11. Long, Y.†; Cao, B.†; Xiong, X.; Chan, A. S. C.; Sun, R. W.-Y.; Zou, T.*, "Bioorthogonal Activation of Dual Catalytic and Anti-Cancer Activities of Organogold(I) Complexes in Living Systems." Angew. Chem. Int. Ed.2021, 60, 4133-4141. (Hot Paper)

  12. Luo, H.; Cao, B.; Chan, A. S. C.; Sun, R. W.-Y.; Zou, T.*, "Cyclometalated Gold(III)-Hydride Complexes Exhibit Visible Light-Induced Thiol Reactivity and Act as Potent Photo-Activated Anti-Cancer Agents." Angew. Chem. Int. Ed.2020, 59, 11046-11052. (Hot Paper, highlighted as inside back cover)

专利

  1. 邹滔滔，罗和江，陈新滋，一种光响应的环金属金(III)氢化物及其制备方法和应用。中国发明专利申请，专利号201911367140.1.

  2. Chi Ming Che, Taotao Zou, Novel gold(III) complexes containing N-heterocyclic carbene ligand, synthesis, and applications in cancer treatment and thiol detection. PCT Int. Appl. US 14/078,742, US8828984 B2 (granted), EP2920186A1, EP2920186A4, US20140142080, WO2014075394A1.

  3. Chi Ming Che, Taotao Zou, A method of using binuclear gold(I) compounds for cancer treatment. PCT Int. Appl. US 14/070,096, US9238659 B2 (granted), CN105452258A, EP2920187A1, EP2920187A4, US20140142065, WO2014075574A1.

  4. Chi Ming Che, Sin Ki Fung, Taotao Zou, A method of using d8 square planar metal complexes to target mismatched DNA. PCT Int. Appl. US 2016-0369354-A1.