于

于世慧

副教授

研究领域：抗肺部耐药性病原菌感染的新型递药系统研究

联系邮箱： yushh8@mail.sysu.edu.cn

教育及工作经历

2009-09 -2013-06   沈阳药科大学         bm11222宝马娱乐网站    药学学士

2013-09 -2018.06   沈阳药科大学         bm11222宝马娱乐网站    药剂学博士

2017.09 -2018.06    Purdue University bm11222宝马娱乐网站    博士联合培养

2018.07-2020.10     Purdue University bm11222宝马娱乐网站    药剂学 博士后

2021.02-2024.02     中山大学               bm11222宝马娱乐网站     药剂学 博士后

2024.04-2025.07     中山大学               bm11222宝马娱乐网站     药剂学 特聘副研究员

2025.08-至今            中山大学               bm11222宝马娱乐网站     药剂学 副教授

 

 

科研项目及成果

  1. 国家自然科学基金青年科学基金项目：清除铜绿假单胞菌生物被膜及分散细菌且防治并发症的自驱动微纳米马达递药系统的功能研究（项目负责人，No.82104080，2022.01～2024.12）

  2. 广东省基础与应用基础研究自然科学基金面上项目：靶向铜绿假单胞菌生物被膜的微环境响应吸入制剂抗肺部慢性感染的研究（项目负责人，No. 2023A1515012909，2023.01～2025.12）

  3. 广东省基础与应用基础研究自然科学基金面上项目：智能吸入制剂摧毁“黏液-感染-炎症”铁三角系统增强抗肺部铜绿假单胞菌感染的研究（项目负责人，No. 2025A1515011086，2025.01~2027.12）

  4. 中山大学青年教师培育项目：靶向铜绿假单胞菌生物被膜的微环境响应吸入制剂抗肺部慢性感染的研究（项目负责人，No. 22qntd4509，2022.01～2022.12）

  5. 广州市基础与应用基础研究项目：多粘菌素B智能纳米递药系统抗临床多重耐药铜绿假单胞菌的研究（项目负责人，No. 2025A04J4525，2025.01~2026.12）

  6. 国家自然科学基金面上项目：脲酶响应型非抗生素抗生物被膜联合免疫激活自组装纳米胶束的构建及清除幽门螺杆菌作用机制的研究（项目第一参与人，No. 82273870，2023.01～2026.12）

  7. 广州市科技计划重点项目：清除幽门螺杆菌感染缓解胃黏膜损伤非抗生素制剂的研发与产业化（项目第一参与人，No. 2023B03J0022，2023.04～2026.03）

  8. 广东省基础与应用基础研究自然科学基金面上项目：智能吸入递药经“除膜四步曲+细菌外膜扰动+抗毒力”策略抗铜绿假单胞菌所致慢性肺部感染（项目第一参与人，No. 2024A1515011193，2024.01～2026.12）

 

发表论文情况

  1. Yuanyuan Li#, Suqi Hao#, Yuhan Fan, Jiabao Hao, Aojie Li, Yalong Wang, Haiyan Hu*, Shijie Ma*, Shihui Yu*, Development of berberine derivative-loaded nanovesicles for ROS-driven eradication of Helicobacter pylori: Overcoming antibiotic resistance and disruption of gut microbiota. Nano Res. DOI: 10.26599/NR.2025.94907674. (一区，IF=9)

  2. Shuqi Zhang#, Shijie Ma#, Suqi Hao, Jieyi Pan, Yuanyuan Li, Gang Yuan, PengyuY Li*, Haiyan Hu*, Shihui Yu*, Fucoidan-modified antibiotic-free nanovesicles: A multidimensional approach to eradicate intracellular and extracellular Helicobacter pylori and restore gastrointestinal homeostasis. Int J Biol Macromol.2025,307(Pt 2):141786. (一区，IF=8.5)

  3. Mao Xu #, Shihui Yu #, *, Pengyu Li, Yili Chen, Yujun Chen, Jieyi Pan, Xin Deng *, Haiyan Hu*. Tailored Multilayer Nanoparticle Against Resistant P. aeruginosa by Disrupting the Stubborn Triad of Thickened Mucus, dense biofilm, hyperinflammation. J Control Release. 2024 Dec 20:S0168-3659(24)00892-7. (一区，IF=11.5)

  4. Pengyu Li, Jieyi Pan, Yating Dong, Yingying Sun, Yalong Wang, Kang Liao, Yili Chen, Xin Deng, Shihui Yu*, Haiyan Hu* Microenvironment responsive charge-switchable nanoparticles act on biofilm eradication and virulence inhibition for chronic lung infection treatment. J Control Release. 2024, 365, 219-235. (一区，IF=11.5)

  5. Shihui Yu, Jieyi Pan, Mao Xu, Yujun Chen, Pengyu Li*, Haiyan Hu*. Antibacterial activity and mechanism of colistin-loaded polymeric nanoparticles for combating multidrug-resistant Pseudomonas aeruginosa biofilms: A synergistic approach. Int J Biol Macromol. 2024 Oct 20;282(Pt 1):136757. (一区，IF=8.5)

  6. Yingying Sun, Tianli Lu, Jieyi Pan, Haonan He, Mao Xu, Yujun Chen, Yan Chen, Pengchao Fang, Xiaoxing Ye, Shuxuan Li, Haiyan Hu *, Yu Shihui *. Dual tobramycin and docosahexaenoic acid loaded nanoemulsions combating Pseudomonas aeruginosa-induced pulmonary infection. Colloids Surf B Biointerfaces. 2024 Jul 11; 242: 114088. (二区，IF=5.6)

  7. Xuan Yang, Yalong Wang, Junke Zhao, Hehui Rong, Yujun Chen, Mengting Xiong, Xiaoxing Ye, Shihui Yu*, Haiyan Hu*. Coordinated regulation of BACH1 and mitochondrial metabolism through tumor-targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy. Acta Pharm Sin B. 2022, 12(10): 3934-3951. (一区，IF=14.6)

  8. Hehui Rong, Yating Dong, Junke Zhao, Xuefei Zhang, Shuxuan Li, Yingying Sun, Tianli Lu, Shihui Yu*, Haiyan Hu*, Fetal milieu-simulating hyaluronic acid-dopamine-chondroitin sulfate hydrogel promoting angiogenesis and hair regeneration for wound healing. Int J Biol Macromol. 2023 Sep 1; 248: 125739. (一区，IF=8.5)

  9. Mengting Xiong, Yuanyuan Li, Haonan He, Suqi Hao, Pengchao Fang, Mao Xu, Yan Chen, Yujun Chen, Shihui Yu*, Haiyan Hu*, Cyclosporine A-loaded colon-targeted oral nanomicelles self-assembly by galactosylated carboxymethyl chitosan for efficient ulcerative colitis therapy. Eur J Pharm Biopharm. 2023 Aug; 189: 152-164. (二区，IF=4.3)

  10. Yiqin Rao, Yingying Sun, Pengyu Li, Mao Xu, Xiaonan Chen, Yalong Wang, Yan Chen, Xin Deng, Shihui Yu*, Haiyan Hu*, Hypoxia-sensitive adjuvant loaded liposomes enhance the antimicrobial activity of azithromycin via phospholipase-triggered releasing for Pseudomonas aeruginosa biofilms eradication. Int J Pharm. 2022 Jul 25; 623: 121910. (二区，IF=5.2)

  11. Shihui Yu, Xiaohui Pu, Maizbha Uddin Ahmed, Heidi H. Yu, Tarun Tejasvi Mutukuri, Jian Li, Qi Tony Zhou*, Spray-freeze-dried inhalable composite microparticles containing nanoparticles of combinational drugs for potential treatment of lung infections caused by Pseudomonas aeruginosa. Int J Pharm. 2021 Dec 15; 610: 121160. (二区，IF=5.2)

  12. Shihui Yu#, Shaoning Wang#, Peizhi Zou, Guihong Chai, Yu-Wei Lin, Tony Velkov, Jian Li, Weisan Pan⁎, Qi Tony Zhou⁎. Inhalable liposomal powder formulations for co-delivery of synergistic ciprofloxacin and colistin against multi-drug resistant gram-negative lung infections. Int J Pharm. 2020, 575: 118915. (二区，IF=5.2)

  13. Shihui Yu, Huiya Yuan, Guihong Chai, Kuan Peng, Peizhi Zou, Xuxi Li, Jian Li, Fanfan Zhou, Hak-Kim Chan, Qi Tony Zhou*. Optimization of inhalable liposomal powder formulations and evaluation of their in vitro drug delivery behavior in Calu-3 human lung epithelial cells. Int J Pharm. 2020 Aug 30;586:119570. (二区，IF=5.2)

  14. Shaoning Wang#, Yu Shihui#, Yuwei Lin, Peizhi Zou, Guihong Chai, Heidi H. Yu, Hasini Wickremasinghe, Nivedita Shetty, Junhong Ling, Jian Li, Qi (Tony) Zhou*. Co-Delivery of Ciprofloxacin and Colistin in Liposomal Formulations with Enhanced In Vitro Antimicrobial Activities against Multidrug Resistant Pseudomonas aeruginosa. Pharm Res. 2018, 35(10): 187. (三区，IF=4.3)

  15. Shihui Yu, Xiaoyu Zhang, Guoxin Tan, Lei Tian, Dandan Liu, Yaxuan Liu, Xinggang Yang*, Weisan Pan*. A novel pH-induced thermosensitive hydrogel composed of carboxymethyl chitosan and poloxamer cross-linked by glutaraldehyde for ophthalmic drug delivery. Carbohydr Polym. 2017, 155:208-217. (一区，IF=12.5)

  16. Shihui Yu, Guoxin Tan, Dandan Liu, Xinggang Yang*, Weisan Pan*. Nanostructured lipid carrier (NLC)-based novel hydrogels as potential carriers for nepafenac applied after cataract surgery for the treatment of inflammation: design, characterization and in vitro cellular inhibition and uptake studies. RSC Adv. 2017, 7(27): 16668-16677. (三区，IF=4.6)

  17. Shihui Yu, Qi Li, Yuenan Li, Haiying Wang, Dandan Liu, Xinggang Yang*, Weisan Pan*. A novel hydrogel with dual temperature and pH responsiveness based on a nanostructured lipid carrier as an ophthalmic delivery system: enhanced trans-corneal permeability and bioavailability of nepafenac. New J Chem. 2017, 41(10): 3920-3929. (三区，IF=2.5) 

  18. Shihui Yu, Qi-Ming Wang, Xin Wang, Dandan Liu, Wenji Zhang, Tiantian Ye, Xinggang Yang, Weisan Pan*. Liposome incorporated Ion sensitive in situ gels for ophthalmic delivery of Timolol Maleate. Int J Pharm. 2015, 480(1–2):128-136. (二区，IF=5.2)

 

申请专利3项

1.朱志红，潘卫三，曲绪楷，杨星钢，梁静阁，李淑娟，于世慧

盐酸曲美他嗪双层渗透泵控释片及制备方法。中国发明专利：201410013277.8;103735528B.

2.潘卫三，张文骥，孔郡，李雪东，陈奋，于世慧，李静，李三鸣

一种金雀异黄素阳离子纳米脂质载体及其制备方法. 中国发明专利：CN 103271892.

3.胡海燕; 李彭宇; 潘洁怡; 董雅婷; 徐茂; 于世慧

抗铜绿假单胞菌感染的纳米粒及制备方法和肺部吸入制剂。中国发明专利：ZL 202310311992.9.