熊小峰

简单介绍

熊小峰  男、博士、教授、博导、院长助理，先后入选国家级高层次青年人才项目、广东省杰青、珠江青年学者、中山大学“百人计划”急需青年杰出人才。2003-2012于四川大学华西bm11222宝马娱乐网站分别获得药学学士和药物化学博士学位，2017年通过中山大学“百人计划”回国工作，主要研究领域为基于药物新靶点的药物化学和化学生物学研究。先后主持国家自然科学基金面上、青年项目，广东省杰出青年科学基金、珠江学者项目、丹麦Lundbeck基金、NovoNodisk基金、中山大学“百人计划”等十余项科研项目，以第一作者或通讯作者在Nature Chemistry、Angew Chem Int Ed、Chem Sci、J Med Chem、Acta Pharma Sin B、Sci Chin Chem、Eur J Med Chem、Org Lett等期刊发表论文30余篇。

本课题组尚有2025年博士生及硕士生（学硕+专硕）招生计划，欢迎联系。

研究方向

药物化学

多肽和蛋白质的化学修饰  

有机合成化学

教育经历

2007年9月至2012年7月：理学博士，药物化学专业，四川大学华西bm11222宝马娱乐网站，导师：陈应春教授

2003年9月至2007年7月：理学学士，药学专业，四川大学华西bm11222宝马娱乐网站

工作经历

2015年1月至2016年11月：助理教授，生物制药中心，丹麦哥本哈根大学

2012年9月至2015年1月：博士后，丹麦哥本哈根大学，合作导师：Kristian Strømgaard教授

教学情况

药物化学

药物合成策略与实例

基础有机化学实验

药学概论

有机化学

科研项目

11. 国家自然科学面上项目，主持，项目编号：82373722，2024.1-2027.12。

11. 广东省卓越青年团队，子课题负责人，2023B1515040006，2024.1-2026.12。

10. 国家“万人计划”青年拔尖人才项目，项目负责人，2023.1-2025.12。

9. 国家自然科学面上项目，主持，项目编号：22077144，2021.1-2024.12。

8. 中山大学青年教师重点培育项目，主持，项目编号：20ykzd15，2020.1-2021.12。

7. 广东省杰出青年科学基金，主持，项目编号：2018B030306017，2018.5-2022.4。

6. 国家自然科学青年基金，主持，项目编号：81602972，2017.1-2019.12。

5. 珠江青年学者项目，主持，2018.10-2021.9。

4. 中山大学“百人计划二期”启动项目，主持，2017.1-2019.12。

3. 广州市民生科技攻关专题，子课题负责人，2019.10-2022.9。

2. 丹麦Lundbeck Foundation，主持 ，140万DKK，2016.10-2018.9。

1. 丹麦NovoNodisk Foundation，主持，110万DKK，2014.8-2016.9。

学术兼职

1. 《药学学报》（APSB）中英文两刊青年编委

2. 《中国化学快报》（Chinese Chemical Letter）青年编委

论文

33. Shumin Ouyang, Shuo Shi, Wen Ding, Yang Ge, Yingxue Su, Jianshan Mo, Keren Peng, Qiyi Zhang, Guopin Liu, Wei Xiao, Peibin Yue, Jinjian Lu, Yandong Wang* Xiaofeng Xiong,* and Xiaolei Zhang*, Neuropeptide Precursor VGF Promotes Liver Metastatic Colonization of G𝜶q Mutant Uveal Melanoma by Facilitating Tumor Microenvironment via Paracrine Loops, Adv Sci, 2024, 2407967.

32. Guangjin Fan; Lu Liu; Jia Ye; Wei Xiao; Xiao-Feng Xiong, Design, synthesis and evaluation of quinazoline derivatives as Gαq/11 proteins inhibitors against uveal melanoma, Bioorganic Chemistry, 2024, 143, 107005.

31. Lu Liu; Zhendong Song; Guangjin Fan; Linlin Lou; Yuanxiang Wang; Xiaolei Zhang; Xiao-Feng Xiong, Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling, Bioorganic & Medicinal Chemistry, 2023, 93, 117457.

30. Zhendong Song, Linlin Lou; Guangjin Fan; Lu Liu; Yang Ge; He Liu; Albert S.C. Chan; Xiaolei Zhang; Xiao-Feng Xiong, Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects, European Journal of Medicinal Chemistry, 2023, 245, 114907.

29. Qi-Long Hu, Jia-Tian Liu, Guangjin Fan, Jian Li, Hu, QL;Liu, JT;Fan, GJ;Li, J;Li, YX;Chan, ASC; Xiong, XF, On-resin peptide modification of methionine residue by employing 2-bromoacetate derivatives, Chin Chem Lett, 2023, 34, 198-202.

28. Feng Zhou, Qi-Long Hu, Ke-Qiang Hou,* Hu, QL;Liu, JT;Fan, GJ;Li, J;Li, YX;Chan, ASC;Xiong, XF*, Construction of α,β-Diamino Diacid Derivatives with Adjacent Acyclic Tetrasubstituted Stereocenters, J. Org. Chem., 2022,87, 8709-8718.

27. Feng Zhou, Yue Huang, Lu Liu, Zhendong Song, Ke-Qiang Hou, Yifan Yang, Hai-Bin Luo, Yi-You Huang*, Xiao-Feng Xiong*, Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects, Biochemical Pharmacology, 2022, 202, 115123.

26. Jun-Jie Deng , Lu Liu , Yang Ge, Zhendong Song  Jie Huang, Guangjin Fan  Xiao-Feng Xiong*, Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma,  Eur. J. Med. Chem, 2022, 239, 114520.

25. Yang Ge, Jun-Jie Deng, Jianzheng Zhu, Lu Liu, Shumin Ouyang, Zhendong Song, Xiaolei Zhang*, Xiao-Feng Xiong*, Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma, Acta Pharmaceutica Sinica B, 2022, 12, 3326-3340.

24. Jian Li, Qi-Long Hu, Zhendong Song, Albert S. C. Chan*, Xiao-Feng Xiong*, Cleavable Cys labeling directed Lys-site-selective stapling and single-site modification, Sci. Chin. Chem, 2022,  65, 1356-1361.

23. Zhendong Song, Yi-You Huang, Ke-Qiang Hou, Lu Liu, Feng Zhou, Yue Huang, Guohui Wan, Hai-Bin Luo,* and Xiao-Feng Xiong*, Discovery and structural optimization of Toddacoumalone derivatives as novel PDE4 Inhibitors for the topical treatment of Psoriasis,  J. Med. Chem. 2022,  65, 4238−4254.

22. Jian Li, Weihong Lai, Ao Pang, Lu Liu, Lianbao Ye, Xiao-Feng Xiong*, On-resin synthesis of linear aryl thioether containing peptides and in-solution cyclization via cysteine S N Ar reaction, Organic Letters, 2022, 24, 1673-1677.

21. Guangjin Fan, Linlin Lou, Zhendong Song*, Xiaolei Zhang*, Xiao-Feng Xiong*, Targeting mutated GTPase KRAS in tumor therapies, Eur. J. Med. Chem, 2021, 226, 113816.

20. Qi-Long Hu, Jia-Tian Liu, Jian Li, Yang Ge, Zhendong Song, Albert S. C. Chan; Xiao-Feng Xiong*, Demethylative alkylation of methionine residue by employing the sulfonium as the key intermediate, Organic Letters, 2021, 23: 8543-8548  

19. Yang Ge,§ Shuo Shi,§ Jun-Jie Deng, Xue-Ping Chen, Zhendong Song, Lu Liu, Linlin Lou, Xiaolei Zhang,* Xiao-Feng Xiong*, Design, Synthesis and Evaluation of Small Molecule Gαq/11 Protein Inhibitors for the Treatment of Uveal Melanoma, J. Med. Chem. 2021, 64, 3131-3152.

18. Jian Li, Jun-Jie Deng, Zhibin Yin, Qi-Long Hu, Yang Ge, Zhen-Dong Song, Ying Zhang, Albert S. C. Chan, Huilin Li, and Xiao-Feng Xiong*, Cleavable and Tunable Cysteine-Specific Arylation Modification by Aryl Thioethers, Chemical Science, 2021, 12, 5209-5215.

17.  Xue-Ping Chen, Ke-Qiang Hou, Feng Zhou, Albert S. C. Chan, and Xiao-Feng Xiong*, Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via [4 + 2] Cyclization of 2‑Benzothiazolimines and Aldehydes, J. Org. Chem., 2021, 86, 1667-1675.

16. Zhen-Dong Song, Mei-Jing Wang, Yang Ge, Xue-Ping Chen, Zi-Yang Xu, Yang Sun*, Xiao-Feng Xiong*, Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies, Acta Pharmaceutica Sinica B, 2021, 11, 13-29.

15. Ke-Qiang Hou, Feng Zhou, Xue-Ping Chen, Yang Ge, Albert S.C. Chan and Xiao-Feng Xiong*, Asymmetric Synthesis of Oxindole-Derived Vicinal Tetrasubstituted Acyclic Amino Acid Derivatives by Mannich-Type Reaction, J. Org. Chem., 2020, 85, 9661-9667.

14. Qi-Long Hu, Ke-Qiang Hou, Jian Li, Yang Ge, Zhen-Dong Song, Albert S.C. Chan and Xiao-Feng Xiong*, Silanol: A bifunctional group for peptide synthesis and late-stage functionalization, Chemical Science, 2020, 11, 6070-6074。 

13. Jun-Xiang Huang, Ke-Qiang Hou, Qi-Long Hu, Xue-Ping Chen, Jian Li, Albert S. C. Chan, and Xiao-Feng Xiong*, Organo-catalytic Asymmetric Three-component Povarov Reactions  of Anilines and Aldehydes, Organic Letters, 2020, 22, 1858-1862.

12. Ke-Qiang Hou, Xue-Ping Chen, Yiyou Huang, Albert S. C. Chan, Hai-Bin Luo, Xiao-Feng Xiong*, Asymmetric total synthesis and biological evaluation of the nutural PDE4 inhibitor toddacoumalone. Organic Letters, 2020, 22, 584-588.

11. Jian Li, Qi-Long Hu, Xue-Ping Chen, Ke-Qiang Hou, Albert S.C. Chan*, Xiao-Feng Xiong*, Asymmetric synthesis of tetrahydropyran[3,2-c]quinolinones via an  organocatalyzed formal [3+3] annulation of quinolinones and MBH 2-naphthoates of nitroolefifin, Chin. Chem. Lett., 2020, 21, 697-670.

10. Jian Li, Yang Ge, Jun-Xiang Huang, Kristian Strømgaard, Xiaolei Zhang, Xiao-Feng Xiong*,,  Heterotrimeric G Proteins as Therapeutic Targets in Drug Discovery, J. Med. Chem. 2020, 63, 5013-5020.

9. Xiao-Feng Xiong,  Hang Zhang, Michael W. Boesgaard, Christina R. Underwood, Hans Bräuner-Osborne, Kristian Strømgaard, Structure-activity relationship study of natural Gq protein inhibitor YM-254890, ChemMedChem, 2019, 14, 865-870. 

8. Xiao-Feng Xiong, Hang Zhang, Christina R. Underwood, Kasper Harpsøe, Thomas J. Gardella, Mie F. Wöldike, Micheal Mannstadt, David. E. Gloriam, Hans Bräuner-Osore, Kristian Strømgaard. “Total synthesis and structure-activity relationship study of a series of selective Gq protein inhibiotrs “. Nature Chemistry. 2016, 8, 1035-1041. 

7. Xiao-Feng Xiong, Mette H. Poulsen, Rama Ashraf, Niels G. Nørager, Kristian Strømgaard, “Structure-activity relationship study of spider polyamine toxins as inhibitors of ionotropic glutamate receptors“. ChemMedChem, 2014, 9, 2661-2670. 封面文章

6. Xiao-Feng Xiong, Quan Zhou, Jing Gu, Lin Dong, Tan-Yu Liu, Ying-Chun Chen, “Trienamine Catalysis with 2,4-Dienones: Development and Application in Asymmetric Diels-Alder Reaction”, Angew. Chem. Int. Ed. 2012, 51, 4401-4404. VIP及封面文章

5. Xiao-Feng Xiong, Hang Zhang, Jing Peng, and Ying-Chun Chen, “Direct Asymmetric Michael Addition of cyclic N-sulfonylimines to α,β-Unsaturated Aldehydes”, Chem. Eur. J. 2011, 17, 2358-2360.

4. Xiao-Feng Xiong, Zhi-Jun Jia, Wei Du, Kun Jiang, Tian-Yu liu, Ying-Chun Chen, “Merging chiral organocatalysts: enantio- and diastereoselective directvinylogous Mannich reaction of alkylimines”, Chem. Commun. 2009, 6994-6996.

3. Kelly L Roszko, Bi Ruiye, Caroline Gorvin, Hans Bräuner-Osborne, Xiao-Feng Xiong,  Asuka Inoue, Rajesh V Thakker, Kristian Strømgaard, Thomas Gardella, Michael Mannstadt, "Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors", JCI Insight, 2017, 2(3):e91079. doi:10.1172/jci.insight.91079

2. Hang Zhang, Xiao-Feng Xiong, Michael W. Boesgaard, Christina R. Underwood, Hans Bruner-Osborne, and Kristian Strømgaard. "Structure–Activity Relationship Studies of the Cyclic Depsipeptide Natural Product YM-254890, Targeting the Gq Protein", ChemMedChem, 2017, DOI: 10.1002/cmdc.201700155.

1. Bo Han, Qing-Ping Liu, Rui Li, Xu Tian, Xiao-Feng Xiong, Jing-Gen Deng, Ying-Chun Chen, “Discovery of Bifunctional Thiourea/Secondary-Amine Organocatalysts for the Highly Stereoselective Nitro-Mannich Reaction of α-Substituted Nitroacetates”,  Chem. Eur. J. 2008，14 , 8094-8097.

书籍和专利

1. Polyamine toxins from spiders and wasps, Xiao-Feng Xiong, Kristian Strømgaard, 2015, Polyamiens: A Universal Molecular Nexus for Growth, Survival, and Specialized Metabolism. Springer, Japan, 201-214.

2. 《药物化学》在线试题库，国家级规划教材，邓卫平、尤启东...熊小峰等，2021， ISBN 978-7-122-37883-5。

3.一种四氢咪唑[1,2-a]吡嗪类化合物、组合物及其制备方法与应用，熊小峰；张小雷；葛阳；石硕；邓俊杰；刘璐；陈新滋；授权号：ZL202011327191.4

4.一种Toddacoumalone 类化合物或其药学上可接受的盐及其制备方法和应

用，熊小峰；侯克强；陈雪萍；黄俊翔；授权号：ZL201910779476.

5.一种环酯肽类 Gq 蛋白抑制剂及其制备方法和应用，熊小峰；李坚；胡启龙；黄俊翔；申请号：201910779900.3

6.一种喹啉酮骨架的PDE4 抑制剂及其制备方法与应用，熊小峰；宋振东；罗海彬；黄仪有；刘璐；侯克强；申请号：202111543984.4

7.一种寡核苷酸 RNA 双链分子及其在制备治疗恶性肿瘤药物中的应用，张小雷；刘培庆；熊小峰；朱剑征；欧阳淑敏；石硕；葛阳；申请号：202111034572.8

诚聘特聘研究员、博士后。除正常薪资外，课题组将每年提供额外津贴。欢迎具有化学、药学或生物学背景的同学加入本课题组。