欧田苗

简单介绍

欧田苗，女，1980年2月生，博士，教授，博士生导师。主要应用基因组学的信息，结合药物化学、分子生物学、结构生物学等学科的理论和技术，进行靶向性创新药物的研究，为发现和发展新型分子靶向治疗药物提供理论和实验依据。

教育经历

工作经历

教学情况

《生物化学与基础分子生物学实验》

《生物化学》

《药学英语》

《科研基础训练》

《现代药物发现中的关键技术》

社会/学术任职

广东省药学会药物化学专业委员会副秘书长

科研项目

先后主持包括国家自然科学基金优秀青年基金、面上项目及其它省部级项目，并作为主要参加人参与了NSFC-广东省联合重点项目、国家自然科学基金重大研究计划、国家自然科学基金重点项目、科技部国际（政府间）合作项目等的研究工作。入选广东省特支计划百千万工程青年拔尖人才、广东省优秀青年教师培育计划、广州市珠江科技新星等人才项目。近5年共发表高水平论文超过80篇，总他引次数超过2600次。其中第一作者及通讯作者文章二十余篇，包括Nucleic Acids Research、Cell Chemical Biology等，并有9篇发表在药物化学顶尖杂志Journal of Medicinal Chemistry。

代表性论著

1. Peng W, Sun ZY, Zhang Q, Cheng SQ, Wang SK, Wang XN, Kuang GT, Su XX, Tan JH, Huang ZS, Ou TM*. Design, Synthesis, and Evaluation of Novel p-(Methylthio)styryl Substituted Quindoline Derivatives as Neuroblastoma RAS (NRAS) Repressors via Specific Stabilizing the RNA G-quadruplex.  J. Med. Chem. 2018 Aug 9;61(15):6629-6646.

2. Wang SK, Wu Y, Wang XQ, Kuang GT, Zhang Q, Lin SL, Liu HY, Tan JH, Huang ZS, Ou TM*. Discovery of Small Molecules for Repressing Cap-Independent Translation of Human Vascular Endothelial Growth Factor (hVEGF) as Novel Antitumor Agents. J. Med. Chem. 2017 Jul 13;60(13):5306-5319.

3. Zeng DY, Kuang GT, Wang SK, Peng W, Lin SL, Zhang Q, Su XX, Hu MH, Wang H, Tan JH, Huang ZS, Gu LQ, Ou TM*. Discovery of Novel 11-Triazole Substituted Benzofuro[3,2-b]quinolone Derivatives as c-myc G-Quadruplex Specific Stabilizers via Click Chemistry. J Med Chem. 2017 Jul 13;60(13):5407-5423.

4. Shan C, Yan JW, Wang YQ, Che T, Huang ZL, Chen AC, Yao PF, Tan JH, Li D, Ou TM*, Gu LQ, Huang ZS*. Design, Synthesis, and Evaluation of Isaindigotone Derivatives To Downregulate c-myc Transcription via Disrupting the Interaction of NM23-H2 with G-Quadruplex. J Med Chem. 2017 Feb 23;60(4):1292-1308.

5. Liu HY, Zhao Q, Zhang TP, Wu Y, Xiong YX, Wang SK, Ge YL, He JH, Lv P, Ou TM*, Tan JH, Li D, Gu LQ, Ren J, Zhao Y, Huang ZS*. Conformation Selective Antibody Enables Genome Profiling and Leads to Discovery of Parallel G-Quadruplex in Human Telomeres. Cell Chem Biol. 2016 Sep 27, 23: 1261-1270.

6. Shan C, Lin J, Hou JQ, Liu HY, Chen SB, Chen AC, Ou TM*, Tan JH, Li D, Gu LQ, Huang ZS*. Chemical intervention of the NM23-H2 transcriptional programme on c-MYC via a novel small molecule..Nucleic Acids Res. 2015 Aug 18; 43(14):6677-91.

7. Wu Y, Zan LP, Wang XD, Lu YJ, Ou TM*, Lin J, Huang ZS, Gu LQ. Stabilization of VEGF G-quadruplex and inhibition of angiogenesis by quindoline derivatives. Biochim Biophys Acta. 2014 Sep; 1840(9):2970-7.

8. Wang SK, Wu Y, Ou TM*. RNA G-Quadruplex: The New Potential Targets for Therapy. Curr Top Med Chem. 2015; 15(19):1947-56.

9. Lin J, Hou JQ, Xiang HD, Yan YY, Gu YC, Tan JH, Li D, Gu LQ, Ou TM*, Huang ZS*. Stabilization of G-quadruplex DNA by C-5-methyl-cytosine in bcl-2 promoter: implications for epigenetic regulation. Biochem Biophys Res Commun. 2013 Apr 19; 433(4):368-73.

10. Ou TM, Lin J, Lu YJ, Hou JQ, Tan JH, Chen SH, Li Z, Li YP, Li D, Gu LQ*, Huang ZS*. Inhibition of cell proliferation by quindoline derivative (SYUIQ-05) through its preferential interaction with c-myc promoter G-quadruplex. J. Med. Chem., 2011 Aug, 54:5671-5679.

11. Wang XD, Ou TM, Lu YJ, Li Z, Xu Z, Xi C, Tan JH, Huang SL, An LK, Li D, Gu LQ, Huang ZS. Turning off transcription of the bcl-2 gene by stabilizing the bcl-2 promoter quadruplex with quindoline derivatives. J Med Chem. 2010 Jun 10; 53(11):4390-8. (The first two authors contributed equally to the paper.) 

12. Ou TM, Lu YJ, Zhang C, Huang ZS, Wang XD, Tan JH, Chen Y, Ma DL, Wong KY, Tang JC, Chan AS, Gu LQ. 74. Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives. J Med Chem. 2007 Apr 5; 50(7):1465-74.

13. Ou TM, Lu YJ, Tan JH, Huang ZS, Wong KY, Gu LQ. G-quadruplexes: targets in anticancer drug design. ChemMedChem. 2008 May; 3(5):690-713.

14. Lu YJ, Ou TM, Tan JH, Hou JQ, Shao WY, Peng D, Sun N, Wang XD, Wu WB, Bu XZ, Huang ZS, Ma DL, Wong KY, Gu LQ. 5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation. J Med Chem. 2008 Oct 23; 51(20):6381-92. (The first two authors contributed equally to the paper.)

15. Tan JH, Ou TM, Hou JQ, Lu YJ, Huang SL, Luo HB, Wu JY, Huang ZS, Wong KY, Gu LQ. Isaindigotone derivatives: a new class of highly selective ligands for telomeric G-quadruplex DNA. J Med Chem. 2009 May 14; 52(9):2825-35. (The first two authors contributed equally to the paper.) 

16. Zhou JL, Lu YJ, Ou TM, Zhou JM, Huang ZS, Zhu XF, Du CJ, Bu XZ, Ma L, Gu LQ, Li YM, Chan AS. Synthesis and evaluation of quindoline derivatives as G-quadruplex inducing and stabilizing ligands and potential inhibitors of telomerase. J Med Chem. 2005 Nov 17; 48(23):7315-21.

获奖情况

欧田苗教授所在研究团队的研究项目《基于天然产物结构改造的靶向性药物先导化合物的基础性研究》于2010年获广东省科学技术奖一等奖和高等学校优秀成果奖-自然科学奖二等奖。

欧田苗教授所在教学团队的教学研究项目《教研融合—药学、化学相关专业本科生物化学立体化课程教学体系的创建与实践》于2017年获广东省教学成果奖一等奖。