陆明

个人简介

陆明，博士，副教授。2007年毕业于中山大学，高分子物理与化学专业，获博士学位，留校从事药剂学研究。2015-2016年赴美国普渡大学bm11222宝马娱乐网站Dr. Lynne S. Taylor课题组进行合作研究。研究兴趣为热熔挤出制剂技术、药物过饱和溶液的相行为和药物固态化学研究。研究成果主要发表在Angewandte Chemie, Chemical Communications, Communications Chemistry, Crystal Growth&Design, International Journal of Pharmaceutics, Pharmaceutical Research等药剂学、化学和晶体学主流期刊上。担任上述期刊审稿人，任中国晶体学会药物晶体学专业委员会理事。

ORCID:  https://orcid.org/0000-0002-2622-1528

ResearchGate:  https://www.researchgate.net/profile/Ming_Lu26

Google Scholar: https://scholar.google.com/citations?user=Cl0aa6IAAAAJ&hl=en

代表性专著章节

1. Ming Lu. Chapter 9. Novel excipients and materials used in 3D printing of pharmaceutical dosage forms. 3D and 4D printing in biomedical applications: Process engineering and additive manufacturing. Editor: Mohammed Maniruzzaman. Publisher: John Wiley, UK, 2019.
2. Ming Lu. Chapter 10: Continuous cocrystallization of poorly soluble APIs to enhance dissolution. Practical guide to hot-melt extrusion: continuous manufacturing and scale-up methodologies. Editor: Mohammed Maniruzzaman. Publisher: SmithersRapra, UK, 2015.

代表性论文

1. Molly Lightowler+, Shuting Li+, Xiao Ou, Jungyoun Cho, Ao Li, Gerhard Hofer, Jiaoyan Xu, Taimin Yang, Xiaodong Zou, Ming Lu*, Hongyi Xu*. Phase identification and discovery of an elusive polymorph of drug-polymer inclusion complex using automated 3D electron diffraction. Angewandte Chemie International Edition, 2024, e202317695. https://doi.org/10.1002/anie.202317695.
2. Binbin Liu+, Changrui Li+, Ziqiao Chena, Xiao Oua, Shuting Lia, Ao Lia, Pin Chen*, Ming Lu*.Molecular insights into the formation of drug-polymer inclusion complex. International Journal of Pharmaceutics, 2024, 652(5): 123761. https://doi.org/10.1016/j.ijpharm.2023.123761
3. Shuting Li, Binbin Liu, Xiao Ou, Haowei Rong, Ming Lu*. Ritonavir revisited: Melt crystallization can easily find the late appearing polymorph II and unexpectedly discover a new polymorph III. Molecular Pharmaceutics, 2023, 20, 8: 3854–3863. https://doi.org/10.1021/acs.molpharmaceut.2c00994
4. Shuting Li,+ Molly Lightowler,+ Xiao Ou, Siyong Huang, Yifan Jiang, Xizhen Li,  Xiaodong Zou, Hongyi Xu,* Ming Lu*. Polymorphism of vemurafenib: Direct structure determination from spherulites using 3D electron diffraction. Communications Chemistry, 2023, 6:18. https://doi.org/10.1038/s42004-022-00804-2
5. Ao Li, Shuting Li, Jiashu Wang, Yunyun Chen, Ming Lu*. Pterostilbene-nicotinamide cocrystal: A case reported of single crystals grown from melt micro droplets. Crystal Growth & Design, 2023, 23(1): 6-10. https://doi.org/10.1021/acs.cgd.2c01073
6. Xiao Ou,+ Shuting Li,+ Yunyun Chen, Haowei Rong, Ao Li, Ming Lu*. Polymorphism in griseofulvin: New story between an old drug and polyethylene glycol. Crystal Growth & Design, 2022, 22, 6: 3778-3785. https://doi.org/10.1021/acs.cgd.2c00156 (Highlighted as the outside front cover)
7. Molly Lightowler,+ Shuting Li,+ Xiao Ou, Xiaodong Zou, Ming Lu,* Hongyi Xu.* Indomethacin polymorph δ revealed to be two plastically bendable crystal forms by 3D electron diffraction: Correcting a 47-year-old misunderstanding. Angewandte Chemie International Edition, 2022, 61(7): e202114985, https://doi.org/10.33774/chemrxiv-2021-s9fhf (Highlighted as the outside front cover)
8. Huanyue Zhou, Yu Wang, Shuting Li, Ming Lu.* Improving chemical stability of resveratrol in hot melt extrusion based on formation of eutectic with nicotinamide. International Journal of Pharmaceutics, 2021, 607: 121042. https://doi.org/10.1016/j.ijpharm.2021.121042
9. Xizhen Li,+ Xiao Ou,+ Bingquan Wang,+ Haowei Rong, Bing Wang, Chao Chang, Baimei Shi, Lian Yu, Ming Lu*. Rich polymorph in nicotinamide revealed by melt crystallization and crystal structure prediction. Communications Chemistry, 2020, 3, 152. https://doi.org/10.1038/s42004-020-00401-1
10. Xizhen Li, Xiao Ou, Haowei Rong, Siyong Huang, Jonas Nyman, Lian Yu, Ming Lu.* The twelfth solved structure of ROY: Single crystals of Y04 grown from melt microdroplets. Crystal Growth & Design. 2020, 20(11): 7093-7097. https://doi.org/10.1021/acs.cgd.0c01017 (Highlighted as the outside front cover)
11. Xiao Ou,+ XizhenLi,+ Haowei Rong, Lian Yu, Ming Lu*. A general method for cultivating single crystals from melt micro droplets. Chemical Communications, 2020, 56: 9950-9953. https://doi.org/10.1039/D0CC03157G
12. Deen Huang, Ziyuan Xie, Qiuhong Rao, Evangelos Liamas, Piaopiao Pan, Shixia Guan*, Zhenyu Jason Zhang, Ming Lu*, Qingguo Li*. Hot melt extrusion of heat-sensitive and high melting point drug: Inhibit the recrystallization of the prepared amorphous drug during extrusion to improve the bioavailability. International Journal of Pharmaceutics, 2019, 565: 316-324. https://doi.org/10.1016/j.ijpharm.2019.04.064
13. Zhengwei Huang, Ling Lin, Cushla McGoverin, Hu Liu, Lili Wang, Qi (Tony) Zhou, Ming Lu*, Chuanbin Wu. Dry powder inhaler formulations of poorly water-soluble itraconazole：A balance between in-vitro dissolution and in-vivo distribution is necessary. International Journal of Pharmaceutics, 2018，551(1-2): 103-110. https://doi.org/10.1016/j.ijpharm.2018.09.018
14. Yongcheng Li, Ming Lu*, Chuanbin Wu*. PVP VA64 as a novel release-modifier for sustained-release mini-matrices prepared via hot melt extrusion. Drug Delivery and Translation Research. 2018, 8(6): 1670-1678. https://doi.org/10.1007/s13346-017-0437-9
15. Ling Lin, Guilan Quan, Tingting Peng, Zhengwei Huang, Vikramjeet Singh, Ming Lu*, Chuanbin Wu*. Development of fine solid-crystal suspension with enhanced solubility, stability, and aerosolization performance for dry powder inhalation. International Journal of Pharmaceuticals. 2017, 533(1): 84-92. https://doi.org/10.1016/j.ijpharm.2017.09.024
16. Ming Lu, Lynne S*. Taylor. Vemurafenib: A tetramorphic system displaying concomitant crystallization from the supercooled liquid. Crystal Growth & Design, 2016, 16 (10): 6033–6042. https://doi.org/10.1021/acs.cgd.6b01066
17. Pin Dong, Ling Lin, Yongcheng Li, Zhengwei Huang, Tianqun Lang, Chuanbin Wu*, Ming Lu*. In-situ synchrotron wide-angle X-ray diffraction as a rapid method for cocrystal/salt screening. International Journal of Pharmaceutics. 2015, 496(1): 107-116. https://doi.org/10.1016/j.ijpharm.2015.03.045
18. Ming Lu, Zhefei Guo, Yongcheng Li, Huishi Pang, Ling Lin, Xin Pan*, Chuanbin Wu*. Application of hot melt extrusion for poorly water-soluble drugs: Limitations, Advances and Future prospects. Current Pharmaceutical Design. 2014, 20(3):369-387. http://doi.org/10.2174/13816128113199990402
19. Zhefei Guo, Ming Lu*, Yongcheng Li, Huishi Pang, Ling Lin, Xu Liu, Chuanbin Wu*. The utilization of drug-polymer interactions for improving the chemical stability of hot-melt extruded solid dispersions. Journal of Pharmacy and Pharmacology. 2014, 66(2): 285-296. https://doi.org/10.1111/jphp.12145
20. Yongcheng Li, Huishi Pang, Zhefei Guo, Ling Lin, Yixuan Dong, Ge Li, Ming Lu*, Chuanbin Wu. Interactions between drugs and polymers influencing hot melt extrusion. Journal of Pharmacy and Pharmacology. 2014, 66(2): 148-166. https://doi.org/10.1111/jphp.12183
21. Xu Liu, Ming Lu*, Zhe fei Guo, Lin Huang, Xin Feng, Chuanbin Wu*. Improving the chemical stability of amorphous solid dispersion with cocrystal technique by hot melt extrusion. Pharmaceutical Research. 2012, 29(3): 806-817. https://doi.org/10.1007/s11095-011-0605-4

(+ Equal contribution, * Corresponding author)

授权专利

1. 陆明，李锡祯，欧霄。化合物单晶及其制备方法。专利号：CN112239890B。（授权日期：2022年6月21日）
2. 陆明，黄思咏，李锡祯，欧霄。化合物单晶及其制备方法。专利号：CN112250663B。（授权日期：2022年8月19日）
3. 吴传斌，董品，陆明。 伊曲康唑的固体分散体制备方法和应用。专利号：201510460617.6。(授权日期：2018年2月5日)
4. 吴传斌，林玲，陆明。伊曲康唑吸入粉雾剂及其制备方法。专利号：CN 104398497B。（授权日期：2017年11月24日）
5. 吴传斌，陆明，黎永诚。富马酸喹硫平缓释制剂及其制备方法。专利号：ZL201410232678.2。（授权日期：2017年10月3日）
6. 吴传斌，陆明，郭喆霏。二氟尼柳固体分散体及其制备方法。专利号：CN 103202811A。（授权日期：2015年4月15日）
7. 吴传斌，刘旭，陆明。一种难溶性药物共晶固体分散体及其制备方法。专利号：CN 102188365 B。（授权日期：2012年12月5日）

主持科研项目

1. 广东省自然科学基金面上项目。剪切流动诱导无定形药物成核及其分子机制研究，2024.1-2026.12。(主持，在研)
2. 广东省自然科学基金面上项目。肠道pH变化所致的克唑替尼原位凝胶化及其机制研究，项目编号2022A1515010393，2021.1-2024.12。(主持，在研)
3. 广州市基础研究计划基础与应用基础研究项目。聚合物熔体高效诱导药物新晶型的分子机制研究，项目编号202102080327，2020.1-2022.12。(主持，结题)
4. 广东省自然科学基金面上项目。基于过冷熔体高效筛选磺酰脲类和格列奈类降糖药物的潜在优势晶型及其调控机制研究，项目编号2020A151501782，2020.3-2023.3。(主持，结题)
5. 广东省自然科学基金面上项目。基于小分子氢键组份的热敏性药物熔融温度调控及其在热熔挤出过程中稳定机制研究，项目编号2018A030313335，2018.5-2021.4。 (主持，结题)
6. 广东省新药设计与评价重点实验室开放基金科研项目。基于过冷液体的药物多晶型研究，2018.9-2020.9。(主持，结题)
7. 国家自然科学基金面上青年基金。基于尺寸效应的剪切诱导聚合物晶型转变研究，项目编号51103184， 2012.1.-2014.12。(主持，结题)
8. 高校基本业务费青年教师培育项目。基于热熔挤出的药物-聚合物相互作用研究，项目编号12ykpy08， 2012.12.1.-2015.12.1。(主持，结题)
9. 广东省医学科研基金。热熔挤出构建伊曲康唑干粉吸入剂及其体内外评价，项目编号A2015169，2015.6-2017.6。(主持，结题)

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