黄艳娟

黄艳娟

副教授

研究领域：创新药物制剂（包括智能响应水凝胶递药系统，基于干细胞/免疫细胞的仿生型递药系统，肿瘤靶向智能药物递送与控释系统）的开发及其在临床重大疾病中的预防与治疗应用。

联系邮箱： huangyj256@mail.sysu.edu.cn

个人简介

黄艳娟，bm11222宝马娱乐网站，副教授，硕导。2020年毕业于bm11222宝马娱乐网站，获药剂学博士学位。先后主持国家自然基金青年项目、广东省自然科学基金-青年提升项目、广东省自然科学基金面上项目、广东省区域联合基金-青年基金、中国博士后基金面上项目、广州市青年博士启航项目、中山大学青年教师培育项目共5项课题。研究成果共发表SCI论文30余篇，其中以第一作者/通讯作者（含共同）先后在Nat Commun、J Control Release、Acta Pharm Sin B、Biomaterials、ACS Nano、Chem Eng J、Asian J Pharm Sci、Int J Pharmaceut、Nanoscale等国内外知名学术刊物发表论文15篇，其中11篇IF>10。申请发明专利5项，其中4项已授权。担任ACS Appl. Mater. Interfaces、Int. J. Pharmaceut.、Acta Biomater.、Acs omega、Int J Biol Macromol等期刊审稿人。Chinese chemical letters杂志青年编委，pharmaceutics 杂志特刊主题"ROS-Mediated Nano Drug Delivery for Antitumor Therapy"客座编辑（欢迎投稿，截稿日期2025.02.28).

研究方向

创新药物制剂（包括智能响应水凝胶递药系统，基于干细胞/免疫细胞的仿生型递药系统，肿瘤靶向智能药物递送与控释系统）的开发及其在临床重大疾病中的预防与治疗应用。

主持科研项目

（1）国家自然科学基金青年基金，82104077/H3408，2022.01至2024.12，30万，主持；

（2）广东省自然科学基金-青年提升, 2024A1515030081，2024.01 - 2026.12，30万，主持;

（3）广东省自然科学基金-面上项目，2021A1515010475，2021.01至2023.12，10万，主持；

（4）广东省区域联合基金-青年基金，2020A1515110305，2020.10至2023.06，10万，主持；

（5）中国博士后科学基金面上项目，2020M683145，2020.11至2023.06，8万，主持；

（6）广州市基础与应用基础研究-青年博士“启航”项目， 2024A04J4148，2024.01-2025.12，5万，主持；

（7）中山大学青年教师培育项目，22qntd4505，2022.01至2023.06，5.9万，主持。

代表性成果

  1. Y. Huang, Z. Guan, X. Dai, Y. Shen, Q. Wei, L. Ren, J. Jiang, Z. Xiao, Y. Jiang, D. Liu, Z. Huang, X. Xu, Y. Luo, C. Zhao*. Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer, Nature Communications, 12(1), (2021), 1-22.（中科院1区Top，IF: 17.694）
  2. Y. Huang#, X. Dai#, Y. Gong#, L. Ren, Y. Luo, Y. Sun, M. Chen, J. Jiang, Z. Guan, C. Zhao*, ROS-responsive sprayable hydrogel as ROS scavenger and GATA6+ macrophages trap for the prevention of postoperative abdominal adhesions, Journal of Controlled Release, 369 (2024) 573-590. （中科院1区Top，IF: 10.8）
  3. T. Zhang#, Y. Huang#（共一第二）, Y. Gong#, X. Shi, D. Xiao, L. Ren, X. Dai, Z. Zeng, C. Zhao*, A ROS-responsive and scavenging hydrogel for postoperative abdominal adhesion prevention, Acta Biomaterialia, 2024, publish online.（中科院1区Top，IF: 9.4）
  4. Y. Huang#, Z. Guan#, Lingling Ren#, Y. Luo, M. Chen, Y. Sun, Y. He, Z. Zeng, X. Dai, J. Jiang, Z. Huang, C. Zhao*. Bortezomib prodrug catalytic nanoreactor for chemo/chemodynamic therapy and macrophage re-education, Journal of Controlled Release, 350, (2022), 332-349.（中科院1区Top，IF: 11.467）
  5. J. Chen#, X. Tan#, Y. Huang#, *(共一第三，共通讯), C. Xu, Z. Zeng, T. Shan, Z. Guan, X. Xu, Z. Huang, C. Zhao*. Reactive oxygen species-activated self-amplifying prodrug nanoagent for tumor-specific Cu-chelate chemotherapy and cascaded photodynamic therapy, Biomaterials, 284, (2022) 121513.（中科院1区Top，IF: 15.304）
  6. Y. Huang#, Z. Xiao#, Z. Guan, Y. Shen, Y. Jiang, X. Xu, Z. Huang, C. Zhao*. A light-triggered self-reinforced nanoagent for targeted chemo-photodynamic therapy of breast cancer bone metastases via ER stress and mitochondria mediated apoptotic pathways, Journal of Controlled Release, 319, (2020), 119-134.（中科院1区Top，IF: 11.467）
  7. Y. Huang, Z. Xiao, Z. Guan, Z. Zeng, Y. Shen, X. Xu, C. Zhao*. Bone-seeking nanoplatform co-delivering cisplatin and zoledronate for synergistic therapy of breast cancer bone metastasis and bone resorption, Acta Pharmaceutica Sinica B, 10(12), (2020), 2384-2403.（中科院1区Top，IF: 14.903）
  8. Y. Huang#, Y. Jiang#, Z. Xiao#, Y. Shen, L. Huang, X. Xu, G. Wei, C. Xu, C. Zhao*. Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/chemodynamic therapy with glutathione depletion, Chemical Engineering Journal, 380, (2020), 122369.（中科院1区Top，IF: 16.744）
  9. Y. Huang#, H. Lai#, J. Jiang#, X. Xu, Z. Zeng, L. Ren, Q. Liu, M. Chen, T. Zhang, X. Ding, C. Zhao, S. Cui*. pH-activatable oxidative stress amplifying dissolving microneedles for combined chemo-photodynamic therapy of Melanoma, Asian Journal of Pharmaceutical Sciences,17, (2022), 679-696.（中科院1区Top，IF: 9.273）
  10. Y. Huang#, T. Zhang#, Q. Wei#, Z. Zeng, Y. Gong, X. Xu, M. Chen, C. Zhao*. “NIR-triggered ROS storage” photodynamic intraocular implant for high-efficient and safe posterior capsular opacification prevention, Asian Journal of Pharmaceutical Sciences, 17(6), (2022), 838-854.（封面论文，中科院1区Top，IF: 9.273）
  11. Y. Huang#, X. Dai#, Z. Guan#, D. Liu, L. Ren, M. Chen, Z. Zeng, J. Jiang, Y. Luo, Y. He, M. Huang, C. Zhao*. A DNA damage nanoamplifier for the chemotherapy of triple-negative breast cancer via DNA damage induction and repair blocking, International journal of pharmaceutics, 622,(2022), 121897（药学2区Top，IF: 6.51）
  12. Y. Huang#, Y. He#, Z. Huang, Y. Jiang, W. Chu, X. Sun, L. Huang, C. Zhao*. Coordination self-assembly of platinum-bisphosphonate polymer-metal complex nanoparticles for cisplatin delivery and effective cancer therapy. Nanoscale, 9 (28), (2017), 10002-10019.（中科院2区Top，IF: 8.307）
  13. J. Jiang#, Y. Huang#（共一第二）, Z. Zeng and C. Zhao*. Harnessing Engineered Immune Cells and Bacteria as Drug Carriers for Cancer Immunotherapy, ACS Nano, 17, (2023), 843–884.（中科院1区Top，IF: 18.027）
  14. Y. He#; Y. Huang#（共一第二）, Z. Huang, Y. Jiang, X. Sun, Y. Shen, W. Chu, C. Zhao*, Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer. Journal of Controlled Release, 264, (2017), 76-88.（中科院1区Top，IF: 11.467）
  15. W. Chu#, Y. Huang#（共一第二）, C. Yang, Y. Liao, X. Zhang, M. Yan, S. Cui, C. Zhao*. Calcium phosphate nanoparticles functionalized with alendronate-conjugated polyethylene glycol (PEG) for the treatment of bone metastasis. International journal of pharmaceutics, 516 (1-2), (2017), 352-363.（药学2区Top，IF: 6.51）
  16. Z. Huang, Y. Huang（第二作者）, M. Chen, J. Chen, Z. Zeng, X. Xu, B. Huang, Y. Luo, Z. Xiao, Y. Ding, Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS, Chemical Engineering Journal 399 (2020) 125667（中科院1区Top，IF: 16.744）.
  17. 黄艳娟，赵春顺，关梓琳。一种近红外光激活型巨噬细胞-纳米前药靶向递药系统的构建及其应用，专利号：202110760793.7，发明授权