郭磊

简单介绍

郭磊 博士、副教授、博士生导师。2017年1月通过中山大学“百人计划”引进入职bm11222宝马娱乐网站。主要研究领域：开发高选择性磷酸二酯酶PDE抑制剂治疗心脑血管疾病，肺动脉高压、肺纤维化等，基于靶标结构开发特异性荧光探针分子及其应用。曾在Acta Pharm. Sin. B.、Adv. Sci.、JACS、Angewante、Adv. Mater.、CCL., Eur. J.  Med. Chem.等国际高影响力期刊上发表论文多篇。

教育经历

2001.09 – 2005.07  中国药科大学，制药工程，学士

2005.09 – 2008.07  中国药科大学，药物化学，硕士

2006.10 – 2008.06  中科院上海有机化学研究所，生命有机国家重点实验室，联合培养

2009.09 – 2013.02  香港浸会大学，有机化学，博士

工作经历

2008.07 – 2009.08  中科院上海有机化学研究所，研究助理

2013.05 – 2016.12  香港浸会大学，博士后

2017.01 – 至今       bm11222宝马娱乐网站，副教授，药物化学

科研项目

国自然面上项目:  靶向磷酸二酯酶PDE10新型苯并咪唑类抑制剂的发现及抗肺动脉高压作用研究  （2023.01-2026.12）

国自然青年科学基金项目:  肿瘤细胞靶向、核仁RNA结构选择性染色的红色吲哚半花菁类探针分子：设计、合成和作用机制研究 (2018.01-2020.12)

广东省自然科学基金-面上项目：苯并咪唑类高选择性PDE10抑制剂的结构优化及抗肺动脉高压研究 （2021.01-2023.12）

中山大学“百人计划二期”启动项目，主持（2017-2019）

论著专利

(1) Hongzhe Huang, Huanxin Xue, Anqi Cai, Han Yuan, Yufen Yao, Runduo Liu, Yi Yang, Quan Wang, Zhe Li, Ting Liu, Yi-You Huang, Wei Dai, Hai-Bin Luo, Xiaozhou Zou*, Xiaoying Wang*, Lei Guo*, Discovery of Novel Azetidine-based Imidazopyridines as Selective and Orally Bioavailable Inhibitors of Phosphodiesterase 10A for the Treatment of Pulmonary Arterial Hypertension, Eur. J.  Med. Chem., 2025, 290, 117537. （共同通讯）

(2)  Quan Wang, Xinyue Liu, Han Yuan, Fengcai Zhang, Jiafei Wu, Dongjing Yang, Jiang Qian, Yi-You Huang, Guihong Chai*, Hai-Bin Luo*, Lei Guo*. Inhalable Carbonyl Sulfide Donor-Hybridized Selective Phosphodiesterase 10A Inhibitor for Treating Idiopathic Pulmonary Fibrosis by Inhibiting Tumor Growth Factor‑β Signaling and Activating the cAMP/Protein Kinase A/cAMP Response Element-Binding Protein (CREB)/p53 Axis,  ACS Pharmacol. Transl. Sci.,2025, 8 (1), 256-269. DOI: 10.1021/acsptsci.4c00671.（共同通讯）

(3) Qin Zeng, Xipeng Li, Jiajun Li, Mengting Shi, Yufen Yao,Lei Guo*, Na Zhi, Tao Zhang*,Totally Caged Type I Pro-Photosensitizer for Oxygen-Independent Synergistic Phototherapy of Hypoxic Tumors.Adv. Sci., 2024, 2400462. https://doi.org/10.1002/advs.202400462.（共同通讯）

(4) Han Yuan#, Fengcai Zhang#, Hongzhe Huang#, Jiafei Wu, Yi Yang, Wanyi Huang, Dongjing Yang, Zhuoming Li, Zhe Li, Ling Huang, Yi-You Huang*, Hai-Bin Luo*, Lei Guo*, Discovery of 3-trifluoromethyl-substituted Pyrazoles as Selective Phosphodiesterase 10A Inhibitors for Orally Attenuating Isoprenaline-induced Cardiac Hypertrophy, Chinese Chem. Lett., 2024, 109965, https://doi.org/10.1016/j.cclet.2024.109965.（共同通讯）

(5) Huanxin Xue#, Jiaye Lu#, Hongwei Yan, Ju Huang, Hai-Bin Luo, Man Shing Wong, Yuqi Gao*, Xiaolei Zhang*, Lei Guo*, γ-Glutamyl Transpeptidase–Activated Indole-Quinolinium Based Cyanine as a Fluorescence Turn-On Nucleolus-Targeting Probe for Cancer Cell Detection and Inhibition, Talanta, 2022, 237, 122898. https://doi.org/10.1016/j.talanta.2021.122898.（共同通讯）

(6) Yuqi Gao, Ju Huang, Qian Zhou, Runduo Liu, Sirui Zhang, Chen Zhang, Yi-You Huang, Zhe Li, Ling Huang, Deyan Wu, Yinuo Wu, Lehui Xiao, Lei Guo*, Hai-Bin Luo*, Discovery of Highly Specific Catalytic-Site-Targeting Fluorescent Probes for Detecting Lysosomal PDE10A in Living Cells, ACS Chem. Biol.202116(5), 857-863.（共同通讯）

(7) Yuncong Yang#, Sirui Zhang#, Qian Zhou#, Chen Zhang, Yuqi Gao, Hao Wang, Zhe Li, Deyan Wu, Yinuo Wu, Yi-You Huang*, Lei Guo*, Hai-Bin Luo*, Discovery of Highly Selective and Orally Available Benzimidazole-Based Phosphodiesterase 10 Inhibitors with Improved Solubility and Pharmacokinetic Properties for Treatment of Pulmonary Arterial Hypertension, Acta Pharm. Sin. B. 2020, 10(12), 2339-2347.（共同通讯）

(8) Yan-Fa Yu#, Chen Zhang#, Yi-You Huang#, Sirui Zhang, Qian Zhou, Xiangmin Li, Zengwei Lai, Zhe Li, Yuqi Gao, Yinuo Wu, Lei Guo*, Deyan Wu*, and Hai-Bin Luo, Discovery and Optimization of Chromone Derivatives as Novel Selective Phosphodiesterase 10 Inhibitors, ACS Chem Neurosci. 2020, 11(7), 1058-1071.（共同通讯）

(9) Lei Guo, Xiao Liu, Tongxin Zhang, Hai-Bin Luo, Hai Hua Fan*, Man Shing Wong*, Star-Shaped Triazine-Cored Ladder-Type Ter(p-phenylene)s for High-Performance Multiphoton Absorption and Amplified Spontaneous Blue Emission, J. Mater. Chem. C2020, 8(5), 1768--1772.

(10) Lei Guo#, Siu Wai Tsang#, Tong-Xin Zhang, Kang-Lun Liu, Yi-Fu Guan, Bo Wang, Han-Dong Sun, Hong-Jie Zhang*, Man Shing Wong*, Efficient Semisynthesis of (-)-Pseudoirroratin A from (-)-Flexicaulin A and Assessment of Their Antitumor Activities, ACS Med. Chem. Lett. 2017, 8(3), 372−376.

(11) Lei Guo, King Fai Li, Xiaoqin Zhang, Kok Wai Cheah, Man Shing Wong, Highly Efficient Multiphoton-Pumped Frequency-Upconversion Stimulated Blue Emission with Ultralow Threshold from Highly Extended Ladder-Type Oligo(p-phenylene)s, Angew. Chem. Int. Ed.2016, 55(36), 10639-10644.

(12) Lei Guo#, Miu Shan Chan#, Di Xu, Dick Yan Tam, Frédéric Bolze*, Pik Kwan Lo*, Man Shing Wong*, Indole-based Cyanine as a Nuclear RNA-Selective Two-Photon Fluorescent Probe for Live Cell Imaging, ACS Chem. Biol. 2015, 10(5):1171-1175.

(13) Lei. Guo, Man Shing Wong*, Multiphoton Excited Fluorescent Materials for Frequency Upconversion Emission and Fluorescent Probes, Adv. Mater. 2014, 26(31), 5400-5428.