顾 琼

顾琼

教授

研究领域：研究兴趣：1、活性天然产物的发现、结构优化、作用靶标和成药性研究;2、基于中药的创新药物研究。研究领域：天然药物化学，药物设计

联系邮箱： guqiong@mail.sysu.edu.cn

简介

顾琼，bm11222宝马娱乐网站教授，博士生导师。中科院昆明植物研究所博士，美国北卡罗莱纳大学教堂山分校访问学者。研究方向为基于天然产物的创新药物研究。从中药中寻找具有抑制铁死亡和抗骨质疏松活性的天然产物，对活性分子进行靶标鉴定和成药性优化，发现药物先导物。以第一或通讯作者，在Nat Comm, ACS Cent Sci, Mol Ther, J Med Chem, Org Lett, J Nat Prod和Phytomedicine等经典期刊发表文章70余篇，申请专利19项，授权专利10项。作为项目负责人获得了1项科技部863计划，3项国家自然科学基金和其他多项省市基金的支持。

研究兴趣

1、活性天然产物的发现、结构优化、作用靶标和成药性研究

2、基于中药的创新药物研究

研究领域

天然药物化学，药物化学

工作经历

2024/4 – 至今，中山大学 bm11222宝马娱乐网站，教授

2015/1 – 2024/4，中山大学 bm11222宝马娱乐网站，副教授

2014/8 - 2015/8，美国北卡罗来纳大学教堂山分校，访问学者

2010/3 - 2014/12，中山大学 bm11222宝马娱乐网站，讲师

2007/7 -  2009/12，中山大学，bm11222宝马娱乐网站，博士后

2001/9 - 2007/3，中科院昆明植物研究所，天然药物化学，博士

主持科研项目

  1. 国家自然科学基金面上基金项目, 22277152, 鸡骨香中二萜类铁死亡抑制剂的发现、结构修饰及其作用机制研究，2023/01-2026/12, 54万元。
  2. 广州市科技计划项目，2023B03J0016，基于抗骨流失药效物质基础和作用机制的四妙丸二次开发研究，2023/4-2026/3，50万元。
  3. 广东省中医药局，20231069，中药单体ATD抗肺纤维化活性作用机制研究，2023/01-2024/12，0.5万元。
  4. 广东省自然科学基金-面上项目，靶向RANKL/RANK通路的二萜类抗骨质疏松先导化合物的设计、合成和活性研究，2019/10-2020/09,10万元。
  5. 国家高新技术发展计划（863计划）, 2012AA020304, 基于中西药学融合的靶向发现与药物分子设计技术，2012/01-2015/12，290万元。
  6. 国家自然科学基金面上基金项目, 81573310, 基于倍半萜内酯片段重组的抗骨质疏松先导化合物的发现、优化和机理研究，2016/01-2019/12, 60万元。
  7. 国家自然科学基金青年基金项目, 81001372, 基于结构片段从天然产物库中筛选以Aß为靶点抗老年痴呆先导化合物，2010/01-2013/12, 20万元, 已结题。
  8. 广东省科技计划项目，基于天然产物片段发现与组装的先导化合物骨架创新技术，2016A020217005，2016/01-2018/12，30万元。
  9. 校内青年教师重点培育项目, 17ykzd13，基于天然产物片段的抗EBV活性先导化合物设计、合成和作用机制研究，2017/01-2018/12, 30万元。
  10. 中科院昆明植物所植物化学与西部植物资源持续利用国家重点实验室开放基金，P2010-KF08，两种菊科植物的化学成分与抗乙肝病毒活性研究，2011/01-2012/12，8万元，已结题。
  11. 企业合作，抗骨质疏松化合物优化及作用靶点确认，2023/09-2024/09，20万元。
  12. 企业合作，天然广谱抗病毒消杀剂的制备工艺和质控标准研究，2022/10-2023/9，21万元。
  13. 企业合作，M001化学成分的分离和结构鉴定，2021/01-2022/01，2.9万元。
  14. 企业合作，抗代谢类和抗炎药物苗头化合物的筛选，2019/04-2020/04, 60万元。
  15. 企业合作，银蓝调脂胶囊组方药材化学组分的提取，2014/01-2014/10,10万元，已结题。
  16.  企业合作，降血脂，抗衰老，抗炎，抗病毒的药物先导化合物筛选研究，2011/10-2014/10，5万元，已结题。

论著专利

代表性论文：（*通讯作者）

  1.  Yuying Fang, Xiucai Chen, Qiongyun Tan, Huihao Zhou, Jun Xu*, Qiong Gu*. Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: a new mechanism of action. ACS Cent Sci 2021, 7, 980-989.
  2. Dane Huang#, Chao Zhao#, Ruyue Li, Bingyi Chen, Yuting Zhang, Zhejun Sun, Junkang Wei, Huihao Zhou*, Qiong Gu*, Jun Xu*. Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis. Nat Commun, 2022, 13: 5338.
  3. Mengjiao Hao, Zhuoji Guan, Zhikang Zhang, Haopeng Ai, Xing Peng, Huihao Zhou, Jun Xu*, Qiong Gu*. Atractylodinol prevents pulmonary fibrosis through inhibiting TGF-b receptor 1 recycling by stabilizing vimentin. Mol Ther, 2023, 31 (10): 3015-3033.
  4. Hao Chen†, Pei Hua†, Dane Huang, Yuting Zhang, Huihao Zhou, Jun Xu*, Qiong Gu*. Discovery of spiro[pyrrolidine-3,3'-oxindole] LXRβ agonists for the treatment of osteoporosis. J Med Chem, 2023, 66(1): 752-765. 
  5. Xing Peng, Qingyun Tan, Zhikang Zhang, Deyin Wu, Jun Xu, Huihao Zhou, Qiong Gu*. Discovery of neo-clerodane diterpenoids from Ajuga campylantha as neuroprotective agents against ferroptosis and neuroinflammation. J Nat Prod, 2023, 86, 2006-2021.

其他通讯作者论文：

  1. Qingyun Tan, Deyin Wu, Yating Lin, Haopeng Ai, Jun Xu, Huihao Zhou, Qiong Gu*. Identifying eleven new ferroptosis inhibitors as neuroprotective agents from FDA-approved drugs. Bioorg Chem, 2024, 146, 107261.
  2. Xing Peng, Shaonan Liu, Yuting Zhang, Jun Xu, Qiong Gu*. Identification and structural modification of ent-rosane diterpenoids from Euphorbia milii inhibiting RANKL-induced osteoclastogenesis. Bioorg Chem, 2024, 145, 107253.
  3. Yuying Fang, Qingyun Tan, Huihao Zhou, Jun Xu*, Qiong Gu*. Discovery and optimization of 2-(trifluoromethyl)benzimidazole derivatives as novel ferroptosis inducers in vitro and in vivo. Eur J Med Chem, 2023, 245, 114905.
  4. Xiufen Jiang, Xifeng Teng, Huiwen Shi, Liudan Cao, Lin He*, Qiong Gu*. Discovery and optimization of olanzapine derivatives as new ferroptosis inhibitors. Bioorg Chem, 2023, 133, 106393.
  5. Shijie Huang, Huifang Li, Jun Xu, Huihao Zhou, Navindra P. Seeram, Hang Ma*, Qiong Gu*. Chemical constituents of industrial hemp roots and their anti-inflammatory activities. Journal of Cannabis Research, 2023, 5:1. 2023-01-16
  6. Huiwen Shi, Xiufen Jiang, Liudan Cao, Xing Peng, Qingyun Tan, Xifeng Teng, Qiong Gu, Lin He. Fitoterapia, 2023, 166: 105461.
  7. Xing Peng, Qingyun Tan, Leiming Wu, Deyin Wu, Jun Xu, Huihao Zhou, Qiong Gu*. Ferroptosis inhibitory aromatic abietane diterpenoids from Ajuga decumbens and structural revision of two 3,4-epoxy group-containing abietanes. J Nat Prod, 2022, 85 (7): 1808-1815.
  8. Zhejun Sun, Yuting Zhang, Xing Peng, Shijie Huang, Huihao Zhou, Jun Xu,* Qiong Gu.* Diverse sesquiterpenoids and polyacetylenes from Atractylodes lancea and their anti-osteoclastogenesis activity. J Nat Prod, 2022, 85, 866-877.
  9. Yanfang Cheng#, Qian Wang#, Zhikang Zhang#, Chao Zhao,* Huihao Zhou, Jun Xu, Qiong Gu.* Saucerneol attenuates nasopharyngeal carcinoma cells proliferation and metastasis through selectively targeting Grp94. Phytomedicine, 2022, 101, 154133.
  10. Yuying Fang#, Qingyun Tan#, Huihao Zhou, Qiong Gu*, Jun Xu*. Discovery of novel diphenylbutene derivative ferroptosis inhibitors as neuroprotective agents. Eur J Med Chem, 2022, 231, 114151.
  11. Mengjiao Hao, Yijun Guo, Zhikang Zhang, Huihao Zhou, Qiong Gu,* Jun Xu.* 6-acrylic phenethyl ester-2-pyranone derivative induces apoptosis and G2/M arrest by targeting GRP94 in colorectal cancer. Bioorg Chem, 2022, 123: 105802.
  12. Yuting Zhang, Chen Hu, Songxuan Zhang, Huihao Zhou, Jun Xu, Jianda Ma, Lie Dai,* Qiong Gu.* Euphoesulatin A prevents osteoclast differentiation and bone loss via inhibiting RANKL-induced ROS production and NF-κB and MAPK signal pathways. Bioorg Chem, 2022, 119: 105511.
  13. Yuting Zhang,^ Xing Peng,^ Zhejun Sun, Chen Hu, Huihao Zhou, Jun Xu, Qiong Gu*. Diverse polyacetylenes from Atractylodes chinensis and their anti-osteoclastogenesis activity. Fitoterapia, 2022, 161, 105233.
  14. Mengyang Xu, Chao Zhao, Biying Zhu, Liangyue Wang, Huihao Zhou, Daoguang Yan,* Qiong Gu.* Jun Xu.* Discovering high potent Hsp90 inhibitors as antinasopharyngeal carcinoma agents through fragment assembling approach. J Med Chem, 2021, 64, 2010-2023.
  15. Songxuan Zhang, Yuting Zhang, Yuying Fang, Hao Chen, Mengjiao Hao, Qingyun Tan, Chen Hu, Huihao Zhou, Jun Xu, Qiong Gu*. Synthesis and evaluation of andrographolide derivatives as potent anti-osteoporosis agents in vitro and in vivo. Eur J Med Chem, 2021, 213, 113185.
  16. Qingyun Tan#, Yuying Fang#, Xing Peng, Huihao Zhou, Jun Xu, Qiong Gu*. A new ferroptosis inhibitor, isolated from Ajuga nipponensis, protects neuronal cells via activating NRF2-antioxidant response elements (AREs) pathway. Bioorg Chem, 2021, 115, 105177.
  17. Qingyun Tan, Yuying Fang, Qiong Gu*. Mechanisms of modulation of ferroptosis and its role in central nervous system diseases. Front Pharmacol, 2021, 657033.
  18. Xing Peng, Qingyun Tan, Huihao Zhou, Jun Xu, Qiong Gu.* Discovery of phloroglucinols from Hypericum japonicum as ferroptosis inhibitors. Fitoterapia, 2021, 153, 104984.
  19. Zhejun Sun, Yuting Zhang, Huihao Zhou, Jun Xu,* Qiong Gu.* Diverse Diterpenoids and sesquiterpenoids from Siegesbeckia pubescens and their activity against RANKL-induced osteoclastogenesis. Bioorg Chem, 2020, 107, 104537.
  20. Shengheng Yuan#, Pei Hua#, Chao Zhao, Huihao Zhou, Jiake Xu, Jun Xu*, Qiong Gu*. Jatrophane diterpenoids from Euphorbia esula as inhibitors of RANKL-induced osteoclastogenesis. J Nat Prod, 2020, 83 (4): 1005-1017.
  21. Pei Hua, Hui Cui, Jun Xu, Runlin Cai, Zhigang She,* Qiong Gu.* Diaporisoindole E inhibits RANKL-induced osteoclastogenesis via suppression of PI3K/AKT and MAPK signal pathways. Phytomedicine, 2020, 75:153234.
  22. Jayachandra Rayadurgam,* Sravani Sana, M. Sasikumar, Qiong Gu.* Palladium catalyzed C-C and C-N bond forming reactions: an update on the synthesis of pharmaceuticals from 2015-2020. Org Chem Front, 2021, 8, 384.
  23. Shengheng Yuan, Yuting Zhang, Pei Hua, Huihao Zhou, Jun Xu, Qiong Gu*. Discovery of ingenane and jatrophane diterpenoids from Euphorbia esula as inhibitors of RANKL-induced osteoclastogenesis. Fitoterapia, 2020, 146: 104718.
  24. Wenjuan Xia#, Pan Luo#, Pei Hua, Peng Ding, Chanjuan Li, Jun Xu, Huihao Zhou, Qiong Gu*. Discovery of a new pterocarpan-type antineuroinflammatory compound from Sphora tonkinensis through suppression of the TLR4/NFκB/MAPK signaling pathway with PU.1 as a potential target. ACS Chem Neurosci, 2019, 10, 295-303.
  25. Yuying Fang, Huihao Zhou, Qiong Gu*, Jun Xu*. Synthesis and evaluation of tetrahydroisoquinoline-benzimidazole hybrids as multifunctional agents for the treatment of Alzheimer's disease. Eur J Med Chem, 2019, 167, 133-145.
  26. Chao Zhao#, Dane Huang#, Ruyue Li, Yida Xu, Shimin Su, Qiong Gu,* Jun Xu.* Identifying novel anti-osteoporosis leads with a chemotype-assembly approach. J Med Chem, 2019, 62, 5885-5900.
  27. Zhiyong Yin, Yan Dai, Pei Hua, Zhejn Sun, Yanjang Cheng, Shengheng Yuan, Ziyang Chen, Qiong Gu.* Discovery of diverse diterpenoid scaffolds from Euphorbia antiquorum and their activity against RANKL-induced osteoclastogenesis. Bioorg Chem, 2019, 92, 103292.
  28. Dane Huang,# Xiangkun Luo,# Zhiyong Yin, Jun Xu,* Qiong Gu.* Diterpenoids from the aerial parts of Flueggea acicularis and their activity against RANKL-induced osteoclastogenesis. Bioorg Chem, 2019, 103453.
  29. Chao Zhao, Dane Huang, Ruyue Xu, Jiake Xu, Qiong Gu*, Jun Xu*. Discovery of new inhibitors against both NF-kappaB and osteoclastogenesis from in-house library with alpha, beta-unsaturated-enone fragment. Bioorg Chem, 2019, 87: 638-646.
  30. Yan Dai#, Shaonan Liu#, Jun Xu, Chao Zhao, Qiong Gu*. Trtiterpenoids from Euphorbia pulcherrima with inhibitory effects on osteoclastogenesis. Fitoterapia, 2019, 134: 355-361.
  31. Yanfang Cheng, Zhiyong Yin, Fuqiang Jiang, Jun Xu, Hao Chen,* Qiong Gu.* Two new lignans from the aerial parts of Saururus chinensis with cytotoxicity toward nasopharyngeal carcinoma. Fitoterapia, 2020, 141: 104344.
  32.  Pan Luo#, Yanfang Cheng#, Zhiyong Yin, Chanjuan Li, Jun Xu*, Qiong Gu*. Monomeric and dimeric cytotoxic guaianolide-type sesquiterpenoids from the aerial parts of Chrysanthmeum indicum. J Nat Prod, 2019, 82 (2): 349-357.
  33. Lin Zhou, Qian Liu, Guoju Hong, Fangming Song, Jinmin Zhao, Jinbo Yuan, Jun Xu, Renxiang Tan, Jennifer Tickner, Qiong Gu*, Jiake Xu*. Cumambrin A prevents OVX-induced osteoporosis via the inhibition of osteoclastogenesis, bone resorption, and RANKL signaling pathways. FASEB journal, 2019, 33 (6): 6726-6735.
  34. Hongao Zhang, Wei Liu, Zhihong Liu, Yingchen Ju, Mengyang Xu, Yue Zhang, Xinyu Wu, Qiong Gu*, Zhong Wang*, Jun Xu*. Discovery of indoleamine 2,3-dioxygenase inhibitors using machine learning based virtual screening. MedChemComm, 2018, 9, 937-945.
  35. Yuying Fang, Wenjuan Xia, Bao Cheng, Pei Hua, Huihao Zhou, Qiong Gu,* Jun Xu.* Design, synthesis, and biological evaluation of compounds with a new scaffold as anti-neuroinflammatory agents for the treatment of Alzheimer’s disease. Eur J Med Chem, 2018, 149, 129-138.
  36. Zhiyong Yin, Yanfang Cheng, Junkang Wei, Xiangkun Luo, Pan Luo, Shaonan Liu, Jun Xu, Hao Chen*, Qing Gu*. Chemical constituents from Daphne tangutica and their cytotoxicity against nasopharyngeal carcinoma cells. Fitoterapia, 2018, 130: 105-111.
  37. Zhihong Liu, Jiewen Du, Xin Yan, Jiali Zhong, Lu Cui, Jinyuan Lin, Lizhu Zeng, Peng Ding, Pin Chen, Xinxin Zhou, Huihao Zhou, Qing Gu*, Jun Xu*. TCMAnalyzer: A chemo- and bioinformatics web service for analyzing traditional chinese medicine. J Chem Inf Model, 2018, 58, 550-555.
  38. Pan Luo, Zhiyong Yin, Zhejun Sun, Hao Chen, Chanjuan Li, Huihao Zhou, Qiong Gu*, Jun Xu. Cembrane-type diterpenoids from Macaranga pustulata. Fitoterapia, 2018, 129, 162-166.
  39. Chanjuan Li,# Bao Cheng,# Sai Fang, Huihao Zhou, Qiong Gu*, Jun Xu*. Design, syntheses and lipid accumulation inhibitory activities of novel resveratrol mimics, Eur J Med Chem, 2018, 143, 114-122.
  40. Xiang-Kun Luo,# Jie Cai,# Zhi-Yong Yin, Pan Luo, Chan-Juan Li, Hang Ma, Navindra P. Seeram, Qiong Gu,* Jun Xu. Fluvirosaones A and B, two indolizidine alkaloids with a pentacyclic skeleton from Flueggea virosa. Org Lett, 2018, 20, 991-994.
  41. Shao-Nan Liu,# Jiayuan Hu,# Shen H. Tan, Qian Wang, Jun Xu, Yan Wang, Yan Yuan,* Qiong Gu*. ent-Rosane diterpenoids from Euphorbia milii showing an Epstein–Barr virus lytic replication assay. RSC Adv., 2017, 7, 46938-46947.
  42. Pan Luo, # Qian Yu, # Shao-Nan Liu, Wen-Juan Xia, Yu-Ying Fang, Lin-Kun An, Qiong Gu*, Jun Xu. Diterpenoids with diverse scaffolds from Vitex trifolia as potential topoisomerase I inhibitor. Fitoterapia, 2017, 120, 108-116.
  43. Pan Luo, Wenjuan Xia, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Yu Zhao*, Qiong Gu*, Jun Xu. Vitepyrroloids A–D, 2-Cyanopyrrole-containing labdane diterpenoid alkaloids from the leaves of Vitex trifolia. J Nat Prod, 2017, 80, 1679-1683.
  44. Yongsheng Lin, Qian Wang, Qiong Gu,* Hongao Zhang, Cheng Jiang, Jiayuan Hu, Yan Wang, Yuan Yan,* Jun Xu*. Semisynthesis of (–)-Rutamarin derivatives and their inhibitory activity on Epstein-Barr virus lytic replication. J Nat Prod, 2017, 1, 53-60.
  45. Jiewen Du, # Xin Yan, # Zhihong Liu, Lu Cui, Peng Ding, Xiaoqing Tan, Xiuming Li, Huihao Zhou, Qiong Gu,* Jun Xu*, cBinderDB: a covalent binding agent database, Bioinformatics, 2016, 33, 1258-1260.
  46. Shao-Nan Liu, Dane Huang, Susan L. Morris-Natschke, Hang Ma, Zhihong Liu, Navindra P. See-ram, Jun Xu, Kuo-Hsiung Lee, Qiong Gu* Euphomilones A and B, ent-rosane diterpenoids with 7/5/6 and 5/7/6 skeletons from Euphorbia milii. Org Lett, 2016, 18, 6132-6135.
  47. Xiangkun Luo, Chanjuan Li, Pan Luo, Xin Lin, Hang Ma, Navindra P. Seeram, Ching Song, Jun Xu,* Qiong Gu*. Pterosin sesquiterpenoids from Pteris cretica as hypolipidemic agents via activating liver X receptors. J Nat Prod, 2016, 79, 3014-3021.
  48. Cheng Jiang, Pan Luo, Jialing Hong, Susan L. Morris-Natschke, Jun Xu, Chin-Ho Chen, Kuo-Hsiung Lee,* Qiong Gu.* Carolignans from the aerial parts of Euphorbia sikkimensis and their anti-HIV activity. J Nat Prod, 2016,79: 578-583.
  49. Taizong Wu,# Qian Wang,# Cheng Jiang, Susan L. Morris-Natschke, Hui Cui, Yan Wang, Yuan Yan, Jun Xu, Kuo-Hsiung Lee,* Qiong Gu.* neo-Clerodane diterpenoids from Scutellaria barbata with activity against Epstein-barr virus lytic replication. J Nat Prod, 2015, 78 (3): 500-509.
  50. Taizong Wu,# Cheng Jiang,# Ling Wang, Susan L. Morris-Natschke, Hui Miao, Lianquan Gu, Jun Xu, Kuohsiung Lee,* Qiong Gu.* 3,5-Diarylpyrazole derivatives obtained by ammonolysis of the total flavonoids from Chrysanthemum indicum extract show potential for the treatment of Alzheimer’s disease. J Nat Prod, 2015, 78: 1593-1599.
  51. Fang Sai, Lei Chen, Miao Yu, Bao Cheng, Yongsheng Lin, Susan L. Morris-Natschke, Kuo-Hsiung Lee, Qiong Gu,* Jun Xu.* Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives. Org. Biomol. Chem, 2015, 13: 4714-4726.
  52. Xin Yan, Chenzhong Liao, Zhihong Liu, Arnold. T. Hagler, Qiong Gu,* Jun Xu.* Chemical structure similarity search for ligand-based virtual screening: methods and computational resources. Curr Drug Targets 2015.
  53. Yali Li, Ling Wang, Zhihong Liu, Chanjuan Li, Jiake Xu, Qiong Gu,* Jun Xu.* Predicting selective liver X receptor β agonists using multiple machine learning methods. Molecular BioSystems, 2015, 11 (5): 1241-1250.
  54. Xiu Le, Qing Gu*, Jun Xu*. Identifying MurI uncompetitive inhibitors by correlating decomposed binding energies with bioactivity. RSC Adv., 2015, 5:40536-40545.
  55. Qianzhi Ding, Chanjuan Li, Ling Wang, Yali Li, Huihao Zhou, Qiong Gu*, Jun Xu*. Identifying farnesoid X receptor agonists by naive Bayesian and recursive partitioning approaches. MedChemComm, 2015, 6, 1393-1403.
  56. L. Wang,* R. R. Zeng, X.Q. Pang, Q. Gu,* W. Tan.* The mechanisms of flavonoids inhibiting conformational transition of amyloid-β42 monomer: a comparative molecular dynamics simulation study. RSC Adv, 2015, 5, 66391.
  57. Ling Wang, Xiu Le, Long Li, Yingchen Ju, Zhongxiang Lin, Qiong Gu*, Jun Xu*. Discovering new agents active against methicillin-resistant Staphylococcus aureus with ligand-based approaches. J Chem Inf Model, 2014, 54, 3186-3197.
  58. Yingying Cao, Ling Wang, Zhongxiang Lin, Fengyin Liang, Zhong Pei, Jun Xu, Qiong Gu*. Dehydroabietylamine derivatives as multifunctional agents for the treatment of Alzheimer’s disease. MedChemComm, 2014, 5, 1736-1743.
  59. Chanjuan Li, Hu Ge, Lujia Cui, Yali Li, Bao Cheng, Guodong Zhang, Ziying Zhang, Hao Qi, Yan Ruan, Qiong Gu,* Jun Xu*. Molecular mechanism of action of K (D) PT as an IL-1RI antagonist for the treatment of rhinitis. RSC Adv, 2014, 4:48741-48749.
  60. Ling Wang, Lei Chen, Zhihong Liu, Minghao Zheng, Qiong Gu*, Jun Xu*. Predicting mTOR Inhibitors with a Classifier Using Recursive Partitioning and Naïve Bayesian Approaches. Plos one, 2014, 9 (5): e95221.
  61. Lei Chen, Ling Wang, Qiong Gu*, Jun Xu*. An in silico protocol for identifying mTOR inhibitors from natural products. Mol Divers, 2014, 18: 841-852.
  62. Taizong Wu, Hui Cui, Bao Cheng, Sai Fang, Jun Xu, Qiong Gu*. Chemical constituents from the roots of Elephantopus scaber L. Biochemical Systematics and Ecology. 2014, 54:65-67.

 

专利：

  1. 顾琼，徐峻，一种苯并咪唑类化合物在制备抗白血病药物中的应用，申请号 2023110766105，申请日 2023-08-24
  2. 顾琼，徐峻，郝梦娇，多烯炔类化合物在制备预防和/或治疗肺纤维化的药物中的应用，申请号 202310621955.8，申请日 2023-08-25
  3. 顾琼，徐峻，郝梦娇, 倍半萜类化合物在制备预防和/或治疗肺纤维化的药物中的应用，申请号 202310787853.3，申请日 2023-10-06
  4. 顾琼，徐峻，陈心春，一种苯并咪唑类化合物在制备抗结核药中的应用，申请号 202211158317.9，申请日 2022-09-22
  5. 顾琼，胡晨，张毓婷，孙喆君，徐峻，多烯炔类化合物及其制备方法和应用。申请号 202111595603，申请日 2021-12-23 授权日2024年2月2日
  6. 顾琼，徐峻，房玉影，一种苯并咪唑类化合物及其制备方法和在制备铁死亡抑制剂中的应用。专利号ZL 2021 1 0097009.9 申请日2021-01-25  授权日2022年9月16日
  7. 顾琼，孙喆君，张毓婷，一种吉马烷型倍半萜内酯类化合物及其制备方法和应用。专利号ZL 2020 1 0880632.7 申请日 2020-08-27。 授权日2023年7月28日
  8. 顾琼，程燕芳，尹智勇，徐峻，一种倍半萜内酯类化合物及其制备方法和在制备防治鼻咽癌的药物中的应用，专利号：ZL 201910773503.5，申请日 2019-08-21 授权日2021年7月13日
  9. 顾琼，佘志刚，华沛，异吲哚酮类化合物在制备防治溶骨性疾病药物中的应用. 专利号：ZL 201910887569.7 申请日：2019-09-19 授权日2023年8月29日
  10. 顾琼，徐峻，黄丹娥，噻唑酰胺衍生物在制备抗骨质疏松药物中的应用，专利号 ZL 201710058515.0 申请日 2017-01-23 授权日 2019年11月26日
  11. 顾琼，徐峻，程燕芳，一种三白草提取物及其在制备抗肿瘤药物中的应用，申请号：201910240029.X
  12. 顾琼，程燕芳，徐峻，三白草中提取的化合物及其在防治鼻咽癌治疗中的应用, 申请号：201910757024.4.
  13. 顾琼，房玉影，徐峻，房玉影，夏文娟，周晖皓，程宝. 一种抗神经炎症的二苯乙烯类似物及其制备方法和应用，专利号：ZL 201810134754.4 申请日 2018-02-09 授权日2021年6月25日
  14. 顾琼，徐峻，房玉影. 一种多功能抗阿尔茨海默病的苯并咪唑衍生物及其制备方法和应用, 专利号：ZL 201811543923.6 申请日 2018-12-17 授权日2021年7月27日
  15. 顾琼，徐峻，程燕芳. 一种野菊花提取物及其制备方法和在制备治疗鼻咽癌感染药物中的应用, 专利号：ZL 201811572377.9 申请日 2018-12-21 授权日2022年2月22日
  16.  顾琼，徐峻，赵超，黄丹娥. N-噻唑-乙酰胺衍生物作为破骨细胞分化抑制剂在制备抗骨质疏松药物中的应用，专利号：ZL 201811625045.2，申请日 2018-12-28 授权日 2021年3月23日
  17.  顾琼、徐峻、黄丹娥、赵超. 噻唑苯甲酰胺衍生物在制备抗骨质疏松、抗骨关节炎药物中的应用, 专利号：ZL 201811623081.5，申请日2018-12-28 授权日 2021年12月24日
  18.  顾琼，徐峻，黄丹娥，一种毛白饭树提取物及其制备方法和在制备治疗骨质疏松药物中的应用，专利号：ZL 201811647789.4 申请日2018-12-29 授权日 2024年4月2日
  19. 顾琼，徐峻，黄丹娥. 一类苯内酰烯酯酰胺类衍生物在制备抗骨质疏松药物中的应用。专利号：ZL 201710058514.6 申请日2017-01-23 授权2019年9月20日
  20. 顾琼，徐峻，刘少南. 一种铁海棠提取物及其制备方法和在制备防治EBV病毒感染药物中的应用。专利号：ZL 2016 1 1208207.3 申请日 2016年12月23日 授权日 2020年12月08日