ZHAO

赵春顺

教授

研究领域：药物新剂型与新技术

办公电话： 020-39943118

联系邮箱： zhaocs@mail.sysu.edu.cn

联系方式

办公电话：020-39943118

电子邮箱：zhaocs@mail.sysu.edu.cn

办公地址：广州市大学城外环东路132号 bm11222宝马娱乐网站，邮编：510006

 

赵春顺   博士，教授，博士生导师。2003毕业于沈阳药科大学药剂学专业，获理学博士学位；1995年7月至1997年8月于河北制药集团从事新药研发工作；1999年9月至2000年8月于石药集团从事新药研发工作；2009年11月至2010年11月在北卡罗来纳大学教堂山分校bm11222宝马娱乐网站从事靶向递药系统研究；2003年9月入职bm11222宝马娱乐网站。近几年负责国家科技重大专项“新药研究开发关键技术研究”专项、“大品种技术改造”专项、国家自然科学基金、广东省科技计划重点项目、平台项目、广州市科技计划重大项目等多项课题。同时，负责并完成企业合作项目30余项；申请专利9项，授权7项；国际PCT 2项，目前已获15个国家授权；发表研究论文60余篇。

研究方向

药物新剂型与新技术

教学情况

本科生：药剂学；药物制剂设计策略与实例

研究生：药物吸收与剂型设计

主持科研项目

  1. 国家自然科学基金面上项目，“基于II型幽门螺旋杆菌为载体的胃癌光动力-免疫治疗及免疫微环境重塑” （82173748，2022-2025）
  2. 国家自然科学基金面上项目，“原位肿瘤疫苗的光激活协同IDO阻断和抗骨重吸收用于乳腺癌骨转移治疗的研究” （81973256，2020-2023）
  3. 国家自然科学基金面上项目，“基于光触发同步释放ROS与药物的眼内长效植入系统的构建及其用于后囊浑浊防治的评价” （81673369，2017-2020）
  4. 国家自然科学基金面上项目，“双功能晶状体囊袋植入系统的构建与性能评价” （81173003，2012-2015）
  5. 广东省科技计划重点项目，“抗缺血性脑卒中候选药物--异吲哚酮类化合物的筛选及临床前研究”，（2015，2015B020211005）
  6. “十一五”国家科技重大专项“重大新药创制”项目“新药研究开发关键技术研究”专项，“高生物利用度及稳定性药物晶型的制备与分析技术及产业化应用”,（2009，2009ZX09501-022，分题负责人）；
  7. “十一五”国家科技重大专项“重大新药创制”项目“大品种技术改造”专项，“丁苯酞高端制剂及其作用靶点、机理研究”，（2008，2008ZX09201-007，分题负责人）；
  8. 企业合作项目30余项。

研究论文

  1. Zeqian Huang#, Yong Luo#, Tao Zhang#, Yaqing Ding, Meixu Chen, Jie Chen, Qiuxing Liu, Yanjuan Huang, and Chunshun Zhao*. A Stimuli-Responsive Small-Molecule Metal-Carrying Prochelator: A Novel Prodrug Design Strategy for Metal Complexes. Angew Chem Int Ed. 2022; 61(28):e202203500. doi: 10.1002/anie.202203500.
  2. Yanjuan Huang#, Zilin Guan#, Lingling Ren#, Yong Luo, Meixu Chen, Yue Sun, Yuanfeng He, Zishan Zeng, Xiuling Dai, Jingwen Jiang, Zeqian Huang, Chunshun Zhao*. Bortezomib prodrug catalytic nanoreactor for chemo/chemodynamic therapy and macrophage re-education. J Control Release. 2022; 350:332-349. https://doi.org/10.1016/j.jconrel.2022.08.037
  3. Jie Chen#, Xiaomin Tan#, Yanjuan Huang#*, Congjun Xu, Zishan Zeng, Ting Shan, Zilin Guan, Xiaoyu Xu, Zeqian Huang, Chunshun Zhao*. Reactive oxygen species-activated self-amplifying prodrug nanoagent for tumor-specific Cu-chelate chemotherapy and cascaded photodynamic therapy. Biomaterials. 2022; 284:121513. doi: 10.1016/j.biomaterials.2022.121513.
  4. Meixu Chen, Zeqian Huang, Meng Xia, Yaqing Ding, Ting Shan, Zilin Guan, Xiuling Dai, Xiaoyu Xu, Yanjuan Huang, Min Huang, Chunshun Zhao*. Glutathione-responsive copper-disulfiram nanoparticles for enhanced tumor chemotherapy. J. Control Release. 2022; 341:351-363. DOI: 10.1016/j.jconrel.2021.11.041
  5. Yanjuan Huang#, Tao Zhang#, Qin Wei#, Zishan Zeng, Yujun Gong, Xiaoyu Xu, Meixu Chen, Chunshun Zhao*. “NIR-triggered ROS storage”photodynamic intraocular implant for high-efficient and safe posterior capsular opacification prevention. Asian J Pharm Sci. 2022; 17(6):838–854. doi: 10.1016/j.ajps.2022.10.004.
  6. Yong Luo#, Zishan Zeng#, Ting Shan, Xiaoyu Xu, Jie Chen, Yuanfeng He, Tao Zhang, Zeqian Huang, Guihong Chai, Yanjuan Huang, Yanfang Zhao, and Chunshun Zhao*. Fibroblast activation protein α activatable theranostic pro-photosensitizer for accurate tumor imaging and highly-specific photodynamic therapy. Theranostics. 2022 May 1;12(8):3610-3627. doi: 10.7150/thno.70308.
  7. Zeqian Huang#, Yaqing Ding#, Yong Luo, Meixu Chen, Zishan Zeng, Tao Zhang, Yue Sun, Yanjuan Huang, Chunshun Zhao*. ROS-triggered cycle amplification effect: A prodrug activation nanoamplifier for tumor-specific therapy. Acta Biomaterialia. 2022; 152:367–379. doi: 10.1016/j.actbio.2022.08.072.
  8. Yanjuan Huang#, Xiuling Dai#, Zilin Guan#, Di Liu, Lingling Ren, Meixu Chen, Zishan Zeng, Jingwen Jiang, Yong Luo, Yuanfeng He, Min Huang, Chunshun Zhao*. A DNA damage nanoamplifier for the chemotherapy of triple-negative breast cancer via DNA damage induction and repair blocking. Int J Pharm. 2022; 622:121897. doi: 10.1016/j.ijpharm.2022.121897.
  9. Yanjuan Huang, Zilin Guan, Xiuling Dai, Yifeng Shen, Qin Wei, Lingling Ren, Jingwen Jiang, Zhanghong Xiao, Yali Jiang, Di Liu, Zeqian Huang, Xiaoyu Xu, Yong Luo, Chunshun Zhao*. Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer. Nat Commun. 2021; 12(1):4310. doi: 10.1038/s41467-021-24564-0.
  10. Xiaoyu Xu, Zishan Zeng, Xin Ding, Ting Shan, Qiuxing Liu, Meixu Chen, Jie Chen, Meng Xia, Yuanfeng He, Zeqian Huang, Yanjuan Huang, Chunshun Zhao*. Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy. Biomaterials, 2021; 227:121128. DOI: 10.1016/j.biomaterials.2021.121128
  11. Congjun Xu,† Zhanghong Xiao,† Jing Wang, Hualu Lai, Tao Zhang, Zilin Guan, Meng Xia, Meixu Chen, Lingling Ren, Yuanfeng He, Yuqi Gao, and Chunshun Zhao*. Discovery of a Potent Glutathione Peroxidase 4 Inhibitor as a Selective Ferroptosis Inducer. J Med Chem. 2021, 64(18):13312-13326. doi: 10.1021/acs.jmedchem.1c00569.
  12. Yifeng Shen, Congjun Xu, Jie Chen, Zilin Guan, Yanjuan Huang, Zishan Zeng, Xiaoyu Xu, Xiaomin Tan, Chunshun Zhao*. Phototriggered Self-Adaptive Functionalized MOC-Based Drug Delivery Platform Promises High Antitumor Efficacy. Adv Healthc Mater. 2021, 10(19):e2100676. doi: 10.1002/adhm.202100676.
  13. Congjun Xu, Haolan Yang, Zhanghong Xiao, Tao Zhang, Zilin Guan, Jie Chen, Hualu Lai, Xiaoyu Xu, Yanjuan Huang, Zeqian Huang, Chunshun Zhao*. Reduction-responsive dehydroepiandrosterone prodrug nanoparticles loaded with camptothecin for cancer therapy by enhancing oxidation therapy and cell replication inhibition. Int J Pharm. 2021; 603:120671. doi: 10.1016/j.ijpharm.2021.120671.
  14. Yanjuan Huang, Zhanghong Xiao, Zilin Guan, Yifeng Shen, Yali Jiang, Xiaoyu Xu, Zeqian Huang, Chunshun Zhao*. A light-triggered self-reinforced nanoagent for targeted chemophotodynamic therapy of breast cancer bone metastases via ER stress and mitochondria mediated apoptotic pathways. J. Control Release, 2020;319:119-134. https://doi.org/10.1016/j.jconrel.2019.12.043
  15. Zeqian Huang, Yanjuan Huang, Meixu Chen, Jie Chen, Zishan Zeng, Xiaoyu Xu, Binyao Huang, Yong Luo, Zhanghong Xiao, Yaqing Ding, Chunshun Zhao*. Bone-targeted oxidative stress nanoamplifier for synergetic chemo/chemodynamic therapy of bone metastases through increasing generation and reducing elimination of ROS. Chem. Eng. J., 2020; 399:125667, https://doi.org/10.1016/j.cej.2020.125667
  16. Xiaoyu Xu, Zishan Zeng, Jie Chen, Binyao Huang, Zilin Guan, Yanjuan Huang, Zeqian Huang, Chunshun Zhao*. Tumor-targeted supramolecular catalytic nanoreactor for synergistic chemo/chemodynamic therapy via oxidative stress amplification and cascaded Fenton reaction. Chem. Eng. J., 2020; 390:124628, https://doi.org/10.1016/j.cej.2020.124628
  17. Yanjuan Huang#, Yali Jiang#, Zhanghong Xiao#, Yifeng Shen, Liangfeng Huang, Xiaoyu Xu, Gaofei Wei, Congjun Xu, Chunshun Zhao⁎ . Three birds with one stone: A ferric pyrophosphate based nanoagent for synergetic NIR-triggered photo/ chemodynamic therapy with glutathione depletion. Chem. Eng. J., 2020;380:122369.
  18. Yanjuan Huang, Zhanghong Xiao, Zilin Guan, Zishan Zeng, Yifeng Shen, Xiaoyu Xu, Chunshun Zhao*. Bone-seeking nanoplatform co-delivering cisplatin and zoledronate for synergistic therapy of breast cancer bone metastasis and bone resorption. Acta Pharm Sin B, 2020;10(12):2384-2403. https://doi.org/10.1016/j.apsb.2020.06.006
  19. Xiaoyu Xu#, Binyao Huang#, Zishan Zeng, Jie Chen, Zeqian Huang, Zilin Guan, Meixu Chen, Yanjuan Huang, Chunshun Zhao*. Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy. Theranostics, 2020; 10(23): 10513-10530. doi: 10.7150/thno.49731
  20. Xiaoyu Xu, Zishan Zeng, Zeqian Huang, Yangwen Sun, Yanjuan Huang, Jie Chen, Junxian Ye, Haolan Yang, Chanzhen Yang, Chunshun Zhao⁎. Near-infrared light-triggered degradable hyaluronic acid hydrogel for ondemand drug release and combined chemo-photodynamic therapy. Carbohyd Polym, 2020; 229:115394.
  21. Xiaoqi Sun, Di Liu, Xiaoyu Xu, Yifeng Shen, Yanjuan Huang, Zishan Zeng, Meng Xia, Chunshun Zhao*. NIR-triggered thermo-responsive biodegradable hydrogel with combination of photothermal and thermodynamic therapy for hypoxic tumor. Asian J Pharm Sci, 2020; 15(6): 713-727. https://doi.org/10.1016/j.ajps.2019.1007
  22. Zeqian Huang#, Gaofei Wei#, Zishan Zeng, Yanjuan Huang, Liangfeng Huang, Yifeng Shen, Xiaoqi Sun, Congjun Xu, Chunshun Zhao*. Enhanced cancer therapy through synergetic photodynamic/immune checkpoint blockade mediated by a liposomal conjugate comprised of porphyrin and IDO inhibitor. Theranostics, 2019; 9(19):5542-5557.
  23. Gaofei Wei, Liangfeng Huang, Yifeng Shen, Zeqian Huang, Xiaoyu Xu, and Chunshun Zhao*. Porphyrin-based porous organic frameworks as oxygen reservoirs to overcome tumor hypoxia for enhanced photodynamic therapy. Adv. Ther., 201900059.
  24. Gaofei Wei#*, LiangfengHuang#, YaliJiang#, YifengShen, ZeqianHuang, YanjuanHuang, XiaoqiSun,  Chunshun Zhao*. Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion. Eur J Med Chem., 2019; 169:53-64.
  25. Liangfeng Huang#, Gaofei Wei#,*, Xiaoqi Sun, Yali Jiang, Zeqian Huang, Yanjuan Huang, Yifeng Shen, Xiaoyu Xu, Yunhui Liao, Chunshun Zhao*. A tumor-targeted Ganetespib-zinc phthalocyanine conjugate for synergistic chemo-photodynamic therapy. Eur J Med Chem., 2018; 151: 294-303.
  26. Xuefei Zhang, Binyao Huang, Yifeng Shen, Chanzhen Yang, Zeqian Huang, Yanjuan Huang, Xiaoyu Xu, Yali Jiang, Xiaoqi Sun, Xining Li, Mina Yan and Chunshun Zhao*. Near infrared light triggered reactive oxygen species responsive nanoparticles for chemo-photodynamic combined therapy. J. Mater. Chem. B, 2018; 6: 2347-2357.
  27. Yuanfeng He1, Yanjuan Huang1, Ziyuan Huang, Yali Jiang, Xiaoqi Sun, Yifeng Shen, Weijing Chu, Chunshun Zhao*. Bisphosphonate-functionalized coordination polymer nanoparticles for the treatment of bone metastatic breast cancer. J Control Release. 2017; 264:76-88.
  28. Xiaoyu Xu, Ziyuan Huang, Zeqian Huang, Xuefei Zhang, Siyu He, Xiaoqi Sun, Yifeng Shen, Mina Yan, Chunshun Zhao*. Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemo-Photothermal Synergistic Cancer Therapy. ACS Appl Mater Interfaces. 2017;9(24):20361-20375
  29. Yanjuan Huang, Yuanfeng He, Ziyuan Huang, Yali Jiang, Weijing Chu, Xiaoqi Sun, Liangfeng Huang, Chunshun Zhao*. Coordination self-assembly of platinum-bisphosphonate polymer-metal complex nanoparticles for cisplatin delivery and effective cancer therapy. Nanoscale. 2017, 9:10002-10019
  30. Ziyuan Huang, Liangfeng Huang, Yanjuan Huang, Yuanfeng He, Xiaoqi Sun, Xiang Fu, Xiaoyu Xu, Gaofei Wei, Dawei Chen and Chunshun Zhao*. Phthalocyanine-based coordination polymer nanoparticles for enhanced photodynamic therapy. Nanoscale. 2017, 9, 15883–15894.
  31. Weijing Chu, Yanjuan Huang, Chanzhen Yang, Yunhui Liao, Xuefei Zhang, Mina Yan, Shengmiao Cui*, Chunshun Zhao*. Calcium phosphate nanoparticles functionalized with alendronate- conjugated polyethylene glycol (PEG) for the treatment of bone metastasis. Int J Pharm., 2017; 516(1-2):352–363
  32. Mina Yan, Chanzhen Yang, Binyao Huang, Zeqian Huang, Liangfeng Huang, Xuefei Zhang, Chunshun Zhao*. Systemic toxicity induced by aggregated layered double hydroxide nanoparticles.  Int J Nanomed., 2017; 12: 7183–7195.
  33. Jiani Huang, Wenyan Gong, Zhiquan Chen, Junying Huang, Qiuhong Chen, Heqing Huang*, Chunshun Zhao*. Emodin self-emulsifying platform ameliorates the expression of FN, ICAM-1 and TGF-β1 in AGEs-induced glomerular mesangial cells by promoting absorption. Eur J Pharm Sci., 2017; 99:128-136.
  34. Ming Lei, Zihang Peng, Qian Dong, Yuanfeng He, Zhaoguo Zhang, Xuefei Zhang, Mina Yan, Chunshun Zhao*. A Novel Capsular Tension Ring as Local Sustained-Release Carrier for Preventing Posterior Capsule Opacification. Biomaterials, 2016; 89:148-156.
  35. Yunhui Liao, Xuefei Zhang, Chenglin Li, Yanjuan Huang, Ming Lei, Mina Yan,Yuefang Zhou, Chunshun Zhao*. Inclusion complexes of HP-β-cyclodextrin with agomelatine:Preparation, characterization, mechanism study and in vivo evaluation. Carbohyd Polym, 2016;147: 415–425
  36. Zhaoguo Zhang, Wenyong Huang, Ming Lei, Yuanfeng He, Mina Yan, Xuefei Zhang, Chunshun Zhao*. Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention. Int J Pharm., 2016;498:1-11
  37. Mina Yan, Zhaoguo Zhang, Shengmiao Cui, Xuefei Zhang,Weijing Chu, Ming Lei, Ke Zeng, Yunhui Liao, Yihui Deng*, Chunshun Zhao*. Preparation and evaluation of PEGylated phospholipid membrane coated layered double hydroxide nanoparticles. Asian J of Pharm. Sci., 2016:396-403
  38. Ke Zeng, Jin Li, Zhaoguo Zhang, Mina Yan, Yunhui Liao, Xuefei Zhang, Chunshun Zhao*. Lipid-coated ZnO nanoparticles as lymphatictargeted drug carriers: study on cell-specific toxicity in vitro and lymphatic targeting in vivo. J. Mater. Chem. B, 2015,3(26):5249-5260
  39. Zujian Lan, Xiaoyu Xu, Wenkai Xu, Jin Li, Zengrong Liang, Xuefei Zhang, Ming Lei, Chunshun Zhao*. Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent. Drug Des Devel Ther., 2015;9:3377-3391
  40. Huafang Zhang, Yan Xiao, Shengmiao Cui, Yuefang Zhou, Ke Zeng, Mina Yan, Chunshun Zhao*. Novel galactosylated poly(ethylene glycol)-cholesterol for liposomes as a drug carrier for hepatocyte-targeting. J of Nanosci and Nanotech., 2015;15(6):4058-4069
  41. Mina Yan, Zhaoguo Zhang, Shengmiao Cui, Ming Lei, Ke Zeng, Yunhui Liao, Weijing Chu, Yihui Deng*, Chunshun Zhao*. Improvement of pharmacokinetic and antitumor activity of layered double hydroxide nanoparticles by coating with PEGylated phospholipid membrane. Int J Nanomed., 2014;9(1):4867-4878
  42. Yuefang Zhou, Weijing Chu, Ming Lei, Jin Li, Wei Du, Chunshun Zhao*. Application of a continuous intrinsic dissolution-permeation system for relative bioavailability estimation of polymorphic drugs. Int J Pharm., 2014;473(1-2):250-258.
  43. Qian Dong, Shaoling Yi, Zihang Peng, Chunshun Zhao*. The preparation and the in vitro pharmacodynamics study of the intracapsular prolong-preparations for the prevention of posterior capsule opacification. Asian J of Pharm. Sci., 2013;8(5):259-267
  44. Wei Du, Yuefang Zhou, Yafei Gong, Chunshun Zhao*. Investigation of physicochemical properties and in-vitro in-vivo evaluation of agomelatine polymorphs. Asian J of Pharm. Sci., 2013;8(4):181-190
  45. Yan Xiao, Huafang Zhang, Zhaoguo Zhang, Mina Yan, Ming Lei, Ke Zeng, Chunshun Zhao*. Synthesis of novel tetravalent galactosylated DTPA-DSPE and study on the hepatocyte targeting efficiency in vitro and in vivo. Int J Nanomed., 2013; 8:3033-3050.
  46. Wanwen Li, Shaoling Yi, Zhouhua Wang, Si Chen, Shuang Xin, Jingwen Xie, Chunshun Zhao*. Self-nanoemulsifying drug delivery system of persimmon leaf extract: Optimization and bioavailability studies. Int J Pharm., 2011; 420(1):161-171.