
谭嘉恒
教授
研究领域:药物化学生物学
联系邮箱: tanjiah@mail.sysu.edu.cn
2024年入学研究生招生计划
尚余学硕名额1位,欢迎同学们咨询报考!
个人简介
谭嘉恒,男,1980年11月生,博士,教授,博士生导师。研究方向为核酸化学生物学与核酸药物化学。
作为负责人先后主持4项国家自然科学基金,获广东省自然科学杰出青年基金及广东特支计划科技青年拔尖人才项目,共发表高水平论文100余篇。其中,作为通讯作者在J. Am. Chem. Soc.、Angew. Chem., Int. Ed.、Nucleic Acids Res.、Chem. Sci.、J. Med. Chem.、Anal. Chem.、Biosens. Bioelectron.等知名学术期刊发表论文30多篇。获授权专利20余项,部分探针已成功商品化。现任Sci. Rep.杂志化学领域编委会成员,2017年获第二十届中国药学会-施维雅青年药物化学奖,2019年入选教育部国家级高层次青年人才。
教育经历
1999.09-2003.07 中山大学化学与化学工程学院,应用化学专业,获学士学位
2003.09-2008.07 bm11222宝马娱乐网站,药物化学专业,获博士学位
工作经历
2008年7月-至今 bm11222宝马娱乐网站
教学情况
生物有机化学;药物化学实验;药物发现中的关键技术
社会/学术任职
Scientific Reports杂志化学领域编委会成员;广东省药学会第十届药物化学专业委员会委员
科研项目(项目负责人)
1. 线粒体DNA G-四链体在癌细胞能量代谢调控中的生物功能与作用机制研究,22277148,国家自然科学基金—面上项目,2023-2026,54万元
2. G-四链体RNA在癌细胞内介导“相分离”过程的分子机制与生物学意义探究,21977124,国家自然科学基金—面上项目,2020-2023,66万元
3. 靶向G-四链体新型荧光原位杂交探针的设计合成及其在RNA结构与功能研究中的应用,21672268,国家自然科学基金—面上项目,2017-2020,65万元
4. 应用多芳基取代咪唑类荧光探针研究癌基因启动子G-四链体作为转录调控元件的分子机制,21272291,国家自然科学基金—面上项目,2013-2016,80万元
5. rDNA G-四链体荧光探针在靶向抗肿瘤药物研发中的应用,2015A030306004,广东省自然科学基金项目—杰出青年科学基金,2015-2019,100万元
6. 特异性靶向识别端粒G-四链体DNA 的Isaidigotone衍生物:结构,结合模式与生物活性的关系,81001400, 国家自然科学基金—青年基金项目,2011-2013, 20万元
7. “广东特支计划”科技青年拔尖人才,2015TQ01R342,2016-2019,30万元
奖励情况
教育部国家级高层次青年人才,2019-2022
第二十届中国药学会-施维雅青年药物化学奖,2017
指导本科生发表第一作者论文
1. Li, Z.-C. (Sophomore); Wu, T.-Y.; Zeng, S.-T.; Fang, L.; Mao, J.-X.; Chen, S.-B.; Huang, Z.-S.; Chen, X.-C.*; Tan, J.-H.* Benzoselenazolium-based hemicyanine dye for G-Quadruplex detection. Bioorganic & Medicinal Chemistry Letters 2022, 70, 128801.
2. Chen, S.-B. (Senior); Tan, J.-H.*; Ou, T.-M.; Huang, S.-L.; An, L.-K.; Luo, H.-B.; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Pharmacophore-based discovery of triaryl-substituted imidazole as new telomeric G-quadruplex ligand. Bioorganic & Medicinal Chemistry Letters 2011, 21, 1004-1009.
代表作
1. Yuan, J.-H.; Tu, J.-L.; Liu, G.-C.; Chen, X.-C.; Huang, Z.-S.; Chen, S.-B.*; Tan, J.-H.* Visualization of ligand-induced c-MYC duplex-quadruplex transition and direct exploration of the altered c-MYC DNA-protein interactions in cells. Nucleic Acids Research 2022, 50, 4246-4257.
2. Chen, X.-C.; Tang, G.-X.; Luo, W.-H.; Shao, W.; Dai, J.; Zeng, S.-T.; Huang, Z.-S.; Chen, S.-B.*; Tan, J.-H.* Monitoring and modulating mtDNA G-quadruplex dynamics reveal its close relationship to cell glycolysis. Journal of the American Chemical Society 2021, 143, 20779-20791.
3. Shao, W.; Zeng, S.-T.; Yu, Z.-Y.; Tang, G.-X.; Chen, S.-B.; Huang, Z.-S.; Chen, X.-C.*; Tan, J.-H.* Tracking stress granule dynamics in live cells and in vivo with a small molecule. Analytical Chemistry 2021, 93, 16297-16301.
4. Lyu, K.; Chen, S.-B.; Chan, C.-Y.; Tan, J.-H.*; Kwok, C. K.* Structural analysis and cellular visualization of APP RNA G-quadruplex. Chemical Science 2019, 10, 11095-11102.
5. Hu, M.-H.; Zhou, J.; Luo, W.-H.; Chen, S.-B.; Huang, Z.-S.; Wu, R.*; Tan, J.-H.* Development of a smart fluorescent sensor that specifically recognizes the c-MYC G-quadruplex. Analytical Chemistry 2019, 91, 2480-2487.
6. Chen, X.-C.; Chen, S.-B.; Dai, J.; Yuan, J.-H.; Ou, T.-M.; Huang, Z.-S.; Tan, J.-H.* Tracking the dynamic folding and unfolding of RNA G-quadruplexes in live cells. Angewandte Chemie, International Edition 2018, 57, 4702-4706.
7. Hu, M.-H.; Wang, Y.-Q.; Yu, Z.-Y.; Hu, L.-N.; Ou, T.-M.; Chen, S.-B.*; Huang, Z.-S.; Tan, J.-H.* Discovery of a new four-leaf clover-like ligand as a potent c-MYC transcription inhibitor specifically targeting the promoter G-quadruplex. Journal of Medicinal Chemistry 2018, 61, 2447-2459.
8. Che, T.; Chen, S.-B.; Tu, J.-L.; Wang, B.; Wang, Y.-Q.; Zhang, Y.; Wang, J.; Wang, Z.-Q.; Zhang, Z.-P.; Ou, T.-M.; Zhao, Y.; Tan, J.-H.*; Huang, Z.-S.* Discovery of novel schizocommunin derivatives as telomeric G-quadruplex ligands that trigger telomere dysfunction and the deoxyribonucleic acid (DNA) damage response. Journal of Medicinal Chemistry 2018, 61, 3436-3453.
9. Hu, M.-H.; Chen, S.-B.; Wang, B.; Ou, T.-M.; Gu, L.-Q.; Tan, J.-H.*; Huang, Z.-S.* Specific targeting of telomeric multimeric G-quadruplexes by a new triaryl-substituted imidazole. Nucleic Acids Research 2017, 45, 1606-1618.
10. Wang, Y.-Q.; Huang, Z.-L.; Chen, S.-B.; Wang, C.-X.; Shan, C.; Yin, Q.-K.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Tan, J.-H.*; Huang, Z.-S.* Design, synthesis, and evaluation of new selective NM23-H2 binders as c-MYC transcription inhibitors via disruption of the NM23-H2/G-quadruplex interaction. Journal of Medicinal Chemistry 2017, 60, 6924-6941.
11. Chen, S.-B.; Hu, M.-H.; Liu, G.-C.; Wang, J.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.*; Tan, J.-H.* Visualization of NRAS RNA G-quadruplex structures in cells with an engineered fluorogenic hybridization probe. Journal of the American Chemical Society 2016, 138, 10382-10385.
12. Hu, M.-H.; Chen, S.-B.; Wang, Y.-Q.; Zeng, Y.-M.; Ou, T.-M.; Li, D.; Gu, L.-Q.; Huang, Z.-S.; Tan, J.-H.* Accurate high-throughput identification of parallel G-quadruplex topology by a new tetraaryl-substituted imidazole. Biosensors & Bioelectronics 2016, 83, 77-84.
13. Yan, J.-W.; Chen, S.-B.; Liu, H.-Y.; Ye, W.-J.; Ou, T.-M.; Tan, J.-H.*; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Development of a new colorimetric and red-emitting fluorescent dual probe for G-quadruplex nucleic acids. Chemical Communications 2014, 50, 6927-6930.
14. Chen, S.-B.; Wu, W.-B.; Hu, M.-H.; Ou, T.-M.; Gu, L.-Q.; Tan, J.-H.*; Huang, Z.-S.* Discovery of a new fluorescent light-up probe specific to parallel G-quadruplexes. Chemical Communications 2014, 50, 12173-12176.
15. Yan, J.-W.; Ye, W.-J.; Chen, S.-B.; Wu, W.-B.; Hou, J.-Q.; Ou, T.-M.; Tan, J.-H.*; Li, D.; Gu, L.-Q.; Huang, Z.-S.* Development of a universal colorimetric indicator for G-quadruplex structures by the fusion of thiazole orange and isaindigotone skeleton. Analytical Chemistry 2012, 84, 6288-6292.
16. Tan, J.-H.; Ou, T.-M.; Hou, J.-Q.; Lu, Y.-J.; Huang, S.-L.; Luo, H.-B.; Wu, J.-Y.; Huang, Z.-S.*; Wong, K.-Y.; Gu, L.-Q.* Isaindigotone derivatives: A new class of highly selective ligands for telomeric G-quadruplex DNA. Journal of Medicinal Chemistry 2009, 52, 2825-2835.