李民

联系方式

电子邮箱：limin65@mail.sysu.edu.cn

办公地址：bm11222宝马娱乐网站329

简单介绍

李民：教授，博士生导师。2007年博士毕业，2007-2012匹兹堡大学和印第安纳大学博士后和研究助理教授。2012年中山大学百人计划副教授入职bm11222宝马娱乐网站。主要从事分子药理研究、基于自噬调控重大疾病的机理及调节剂研究。主持国家自然科学基金面上项目、广东省自然科学基金等科研项目。以通讯作者在权威学术期刊 Medicinal Research Reviews, Autophagy, Redox Biology, APSB, JBC, Cell Death&Disease 等发表论文多篇。授权专利4项。2021年荣获广东省药理学会科技成果奖一等奖（排名第一）。编写《药理学实验教程》（主编）、《药物筛选和成药性评价的基础与实践》（副主编）。目前为广东省成药性评估与评价工程实验室副主任、广东省药理学会药物筛选与评价专委会以及内分泌与代谢药理专委会常务委员。

教学情况

药理学

药理学实验（课程负责人）

药物筛选技术与进展

研究方向

1、分子药理、药效学评价及成药性评估。
2、基于自噬调控重大疾病的机制研究、新靶点发现及选择性抑制剂研究。
3、非经典自噬发生机制及、细胞器互作。

社会/学术任职

中国药理学会表观遗传药物专业委员会，委员

广东省药理学会新药筛选与评价专业委员会，常务委员

广东省药理学会内分泌与代谢药理专业委员会，常务委员

广东省成药性评估与评价工程实验室，副主任

科研项目

国自然面上项目（2017-2020, 2020-2023, 2025-2028）

省自然项目 （2013, 2016, 2019, 2021）

论著专利 （2011年后）

第一/通讯文章

[39] Z. Xu#, J. Huang#, M. Wen#, X. Zhang, D. Lyu, S. Li, H. Xiao, M. Li*, C. Shen*, H. Huang*, Gentiopicroside ameliorates glucose and lipid metablism in T2DM via targeting FGFR1, Phytomedicine, 2024, 132: 155780.

[38] L. Liang#, J. Zeng#, R. Liu#, Z. Zheng, D. Lyu, X. Zhang, M. Wen, M. Li, H. Xiao, X. Sun, M. Li*, H. Huang*, Polydatin attenuates diabetic renal inflammatory fibrosis via the inhibition of STING pathway, Biochemical Pharmacology, 2024, 226: 116373.

[37] Y. Wang, A. Huang, L. Chen, F. Sun, M. Zhao, M. Zhang, Y. Xie, S. Xu, M. Li*, L. Hong*, G. Li*, R. Wang*, Design and synthesis of dual BRD4/Src inhibitors for treatment of triple-negtive breast cancer, European Journal of Medicinal Chemistry, 2024, 264: 116009.

[36] Y. Dai#, W. Yang#, H. Song#, X. He, R. Guan, Z. Wu, X. Jiang, M. Li*, P. Liu*, J. Chen*, Long-term effects of chronic exposure to electronic cigarette aerosol on the cardiovascular and pulmonary system in mice: A comparative study to cigarette smoke, Environment International, 2024, 185: 108521.

[35] J. Tang#, D. Fang#, J. Zhong, M. Li*, Missing WD40 Repeats in ATG16L1 Delays Canonical Autophagy and Inhibits Noncanonical Autophagy, Int. J. Mol. Sci., 2024, 25: 4493.

[34] C. Sun#, Y. Chen#, Q. Gu#, Y. Fu, Y. Wang, C. Liu, H. Xie, Y. Liao, Z. Zheng, P. Liu, M. Li*, UBE3C tunes autophagy via ATG4B ubiquitination, Autophagy, 2024, 20: 645-658.

[33] M. Zhao#, W. Fan#, Y. Wang#, P. Qiang, Z. Zheng, H. Shan, M. Zhang, P. Liu, Y. Wang, G. Li*, M. Li*, L. Hong*, M335, a novel small-molecule STING agonist activates the immune response and exerts antitumor effects, European Journal of  Medicinal Chemistry, 2024, 264: 116018

[32] Z. Zheng, M. Zhao, H. Shan, D. Fang, Z. Jin, J. Tang, Z. Liu, L. Hong, P. Liu*, M. Li*, Noncanonical autophagy is a new strategy to inhibit HSV-1 through STING1 activation, Autophagy, 2023, 19: 3096-3112.

[31] L. Wang#, Y. Wang#, X. Yang#, K. Duang, X. Jiang, J. Chen, P. Liu*, M. Li*, Cytotoxicity and cell injuries of flavored electronic cigarette aerosol and mainstream cigarette smoke: A comprehensive in vitro evaluation, Toxicology Letters, 2023, 374: 96-110.

[30] H. Xie#, P. Qiang#, Y. Wang, F. Xia, P. Liu, M. Li*, Discovery and mechanism studies of a novel ATG4B inhibitor Ebselen by drug repurposing and its anti-colorectal cancer effects in mice, Cell & Bioscience, 2022, 12: 206.

[29] J. Long#, X. Luo#, D. Fang#, H. Song, W. Fang, H. Shan, P. Liu, B. Lu, X.-M. Yin*, L. Hong*, M. Li*, Discovery of an autophagy inducer J3 to lower mutang huntingtin and alleviate Huntington's disease-related phenotype, Cell & Bioscience, 2022, 12: 167.

[28] W. Li, L. X. Luo, Q. Q. Zhou, ...W.-Y. Sun*, M. Li*, R.-R. He*, Phospholipid peroxidation inhibits autophagy via stimulating the delipidation of oxidized LC3-PE, Redox Biology, 2022, 55: 102421.

[27] F. Xia#, Y. Fu#, H. Xie#, Y. Chen, D. Fang, W. Zhang, P. Liu, M. Li*, Suppression of ATG4B by copper inhibits autophagy and involves in Mallory body formation, Redox Biology, 2022, 52: 102284.

[26] L. Wang#, Y. Wang#, J. Chen, P. Liu*, M. Li*, A Review of Toxicity Mechanism Studies of Electronic Cigarettes on Respiratory System, Int. J. Mol. Sci. 2022, 23: 5030.

[25] M. Zhao, H. Xie, H. Shan, Z. Zheng, G. Li, M. Li*, Liang Hong*, Development of thyroid hormones and synthetic thyromimetics in non-alcoholic fatty liver disease, Int. J. Mol. Sci. ,2022, 23: 1102.

[24] L. Wang, Y. Wang, J. Chen, X. M. Yang, X. T. Jiang, P. Liu*, M. Li*, Comparison of biological and transcriptomic effects of conventional cigarette and electronic cigarette smoke exposure at toxicological dose in BEAS-2B cells, Ecotoxicology and Enviromental Safety, 2021, 222: 112472.

[23] Y. Luo#, Y. Fu#, Z. Huang*, M. Li*, Transition metals and metal complexes in autophagy and diseases, Journal of Cellular Physiology, 2021, 236: 7144–7158.

[22] D. Fang, H. Xie, T. Hu, H. Shan, M. Li*, The binding features and functions of ATG3, Frontiers in Cell and Developmental Biology, 2021, 9: 685625.

[21] F. Xia, P. Liu*, M. Li*, The regulatory factors and pathological roles of autophagy‐related protein 4 in diverse diseases: Recent research advances, Medicinal Research Reviews, 2021, 41:1644-1675.

[20] G. Li#, M. Zhao#, J. Xie#, Y. Yao, L. Mou, X. Zhang, X. Guo, W. Sun, Z. Wang, J. Xu, T. Hu, M. Zhang, M. Li*, L. Hong*, Efficient synthesis of cyclic amidine-based fluorophores via 6p-electrocyclic ring closure, Chemical Science, 2020, 11: 3586-3591.

[19] Y. Fu#, Q. Gu#, L. Luo#, J. Xu, Y. Luo, F. Xia, F. Han, L. Hong, X.M. Yin, Z. Huang*, M. Li*,  New anti-cancer strategy to suppress colorectal cancer growth through inhibition of ATG4B and lysosome function, Cancers, 2020, 12: 1523. 

[18] X. Zheng#, Z. Yang#, Q. Gu, F. Xia, Y. Fu, P. Liu, X.M. Yin, M. Li*,  The protease activity of human ATG4B is regulated by reversible oxidative modification, Autophagy, 2020, 16: 1838-1850. 

[17] Q. Dai, Z. Zheng, F. Xia, P. Liu*, M. Li*, A one-step specific assay for continuous detection of sirtuin 2 activity, Acta Pharmaceutica Sinica. B, 2019, 9: 1183-1192.

[16] Y. Fu#, Z. Huang#, L. Hong, J.H. Lu, D. Feng, X.M. Yin*, M. Li*, Targeting ATG4 in Cancer Therapy, Cancers, 2019, 11: 649. 

[15] H. Shan#, X. Zheng#, M. Li*, The effects of Astragalus membranaceus active extracts on autophagy-related diseases, Int. J. Mol. Sci., 2019, 20: e1904. 

[14] Y. Liu#, X. Luo#, H. Shan#, Q. Gu, X. Zheng, Q. Dai, F. Xia, Z. Zheng, P. Liu, X. M. Yin, L. Hong*, M. Li*, Niclosamide triggers non-canonical LC3 lipidation, Cells, 2019, 8: 248.

[13] Y. Fu#, L. Hong#, J. Xu#, G. Zhong#, Q. Gu, Q. Gu, Y. Guan, X. Zheng, Q. Dai, X. Luo, C. Liu, Z. Huang, X.M. Yin, P. Liu*, M. Li*, Discovery of a small molecule targeting autophagy via ATG4B inhibition and cell death of colorectal cancer cells in vitro and in vivo, Autophagy, 2019, 15: 295-311.

[12] W. Wen#, J. Chen#, L. Ding, X. Luo, X. Zheng, Q. Dai, Q. Gu, C. Liu, M. Liang, X. Guo, P. Liu*, M. Li*, Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy, Arch Biochem Biophys, 2018, 657: 31-40.

[11] J. Chu#, Y. Fu#, J. Xu#, X. Zheng, Q. Gu, X. Luo, Q. Dai, S. Zhang, P. Liu, L. Hong*, M. Li*, ATG4B inhibitor FMK-9a induces autophagy independent on its enzyme inhibition, Arch Biochem Biophys, 2018, 644: 29-36.

[10] S.T. Li, Q. Dai, S.X. Zhang, Y.J. Liu, Q.Q. Yu, F. Tan, S.H. Lu, Q. Wang, J.W. Chen, H.Q. Huang, P.Q. Liu*, M. Li*, Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-kappaB signaling pathway and activating the PI3K/Akt/Nrf2 pathway, Acta Pharmacol Sin, 2018, 39: 1294-1304.

[9] M. Li*, Y. Fu, Z. Yang, X.M. Yin*, Measurement of the activity of the Atg4 cysteine proteases, Methods Enzymol, 2017, 587: 207-225.

[8] Y. Gao#, Y. Liu#, L. Hong, Z. Yang, X. Cai, X. Chen, Y. Fu, Y. Lin, W. Wen, S. Li, X. Liu, H. Huang, A. Vogt, P. Liu*, X.M. Yin*, M. Li*, Golgi-associated LC3 lipidation requires V-ATPase in noncanonical autophagy, Cell Death Dis, 2016, 7: 2330.

[7] M. Zhang, W.S. Sun, G.M. Zhu, G.J. Bao, B.Z. Zhang, L. Hong*, M. Li*, R. Wang*, Enantioselective dearomative arylation of isoquinolines, ACS Catal, 2016, 6: 5290-5294.

[6] J. Zhou, Z. Yang, F. Zhang, H.B. Luo, M. Li*, R. Wu*, A salt bridge turns off the foot-pocket in class-II HDACs, Phys Chem Chem Phys, 2016, 18: 21246-21250.

[5] M. Li*, Z. Yang, L.L. Vollmer, Y. Gao, Y. Fu, C. Liu, X. Chen, P. Liu, A. Vogt, X.M. Yin*, AMDE-1 is a dual function chemical for autophagy activation and inhibition, PLoS One, 2015, 10: e0122083.

[4] S. Gao, H. Li, Y. Cai, J.T. Ye, Z.P. Liu, J. Lu, X.Y. Huang, X.J. Feng, H. Gao, S.R. Chen, M. Li*, P.Q. Liu*, Mitochondrial binding of alpha-enolase stabilizes mitochondrial membrane: its role in doxorubicin-induced cardiomyocyte apoptosis, Arch Biochem Biophys, 2014, 542: 46-55.

[3] M. Li, B. Khambu, H. Zhang, J.H. Kang, X. Chen, D. Chen, L. Vollmer, P.Q. Liu, A. Vogt, X.M. Yin*, Suppression of lysosome function induces autophagy via a feedback down-regulation of MTOR complex 1 (MTORC1) activity, J Biol Chem, 2013, 288: 35769-35780.

[2] M. Li, X. Chen, Q.Z. Ye, A. Vogt, X.M. Yin*, A high-throughput FRET-based assay for determination of Atg4 activity, Autophagy, 2012, 8: 401-412.

[1] M. Li, Y.F. Hou, J.S. Wang, X.Y. Chen, Z.M. Shao, X.M. Yin*, Kinetics comparisons of mammalian Atg4 homologues indicate selective preferences toward diverse Atg8 substrates, J Biol Chem, 2011, 286: 7327-7338.

其他

本课题组招收特聘研究员、副研究员及博士后人员，欢迎对抗病毒药物分子机制、自噬发生机制、自噬在疾病调控中的作用、细胞器等方向感兴趣。直接联系本人。

欢迎研究生报考！