蓝文健

联系方式

办公电话：020-39943042

电子邮箱：lanwj@mail.sysu.edu.cn

简单介绍

蓝文健：bm11222宝马娱乐网站教授、博导。美国Oregon State University访问学者，广东省高等学校 “千百十人才培养工程”培养对象。在中山大学化学学院海洋天然产物研究所获得博士学位后留校任教，多年来一直致力于南海海洋生物共生微生物的药用活性物质研究。建立了高效的微生物分离与种属鉴定技术；发展了氨基酸导向培养方法等多种培养策略，激活微生物“沉默基因”，诱导真菌多产、高产结构新颖活性生物碱等代谢产物；开展基于化学结构新颖性和生物活性的代谢产物研究，发现先导化合物；探讨重要代谢产物的生源合成途径。从南海软珊瑚、海绵、海星等生物体内分离纯化1000多株真菌和细菌，鉴定数百株微生物种属；开展部分真菌代谢产物研究，从中发现500余个化合物，近百个化合物具有显著抗肿瘤、抗病毒、抗菌等药用活性。近两年重点探索深海、热液、冷泉等极端环境微生物活性代谢产物，发现治疗恶性肿瘤、病毒性感染等重大疾病的候选药物。先后主持3项国家自然科学基金、8项广东省科技计划和自然科学基金等10余项科研项目。以第一或通讯作者在Organic Letters，Journal of Natural Products，Bioorganic Chemistry，Frontiers in Microbiology等国际著名期刊发表高水平文章50余篇；申请专利7件，其中4件获得授权。目前担任广东药学会第十七届制药专委会常务委员，中国菌物学会化学专委会委员。

研究方向

1．海洋微生物（真菌、细菌、放线菌等）活性代谢产物的发现与药用研究。

2．岭南中药的活性成分研究。

课题组长期招聘微生物学、天然药物化学、药物化学、生物化学与分子生物学等专业的特聘研究员、特聘副研究员和博士后。

教学情况

本科生：《天然药物化学》（理论和实验课）《有机化学实验》
研究生：《天然产物化学及其研究方法》

论著专利

以通讯作者发表的部分论文：

1. Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41-1 to Maximize Alkaloid Diversity. Organic Letters, 2017, 19(18), 4888-4891.
2. Pseudellones A−C, Three Alkaloids from the Marine-Derived Fungus Pseudallescheriaellipsoidea F42−3. Organic Letters, 2015, 17(21), 5156-5159. 
3. Potential Antidiabetic Fumiquinazoline Alkaloids from the Marine-Derived Fungus Scedosporium apiospermum F41‑1. Journal of Natural Products. 2020, 83(4), 1082-1091.
4. L-Tryptophan Induces a Marine-Derived Fusarium sp. to Produce Indole Alkaloids with Activity against the Zika Virus. Journal of Natural Products, 2020, 83(11), 3372-3380.
5. L‑Phenylalanine Alters the Privileged Secondary Metabolite Production in the Marine-Derived Fungus Trichoderma erinaceum F1‑1. Journal of Natural Products, 2020, 83 (1), 79-87.
6. β-Carboline Alkaloids from the Deep-Sea Fungus Trichoderma sp. MCCC 3A01244 as a New Type of Anti-Pulmonary Fibrosis Agent that Inhibits TGF-b/Smad Signaling Pathway. Frontiers in Microbiology, 2022.
7. Biotransformations of Anthranilic Acid and Phthalimide to Potent Antihyperlipidemic Alkaloids by the Marine-Derived Fungus Scedosporium apiospermum F41-1. Bioorganic Chemistry, 2021, 116, 105375: 1-8.
8. Phomaligols F-I, Polyoxygenated Cyclohexenone Derivatives from Marine-Derived Fungus Aspergillus flavus BB1. Bioorganic Chemistry, 2021, 115, 105269: 1-8.
9. Pseudapenes A-C, Sesquiterpenoids from the Marine-Derived Fungus Pseudallescheria apiosperma F52-1. Tetrahedron Letters, 2019, 60(34), 150953: 1-4.
10. Characterization, Antioxidant and Antitumor Activities of Oligosaccharides Isolated from Evodia lepta (Spreng) Merr. by Different Extraction Methods. Antioxidants 2021, 10(11), 1842.
11. Secondary Metabolites with Chemical Diversity from the Marine-Derived Fungus Pseudallescheria boydii F19-​1 and Their Cytotoxic Activity. RSC Advances, 2016, 6(80), 76206-76213.
12. Discovery of Aromadendrane Anologues from the Marine-Derived Fungus Scedosporium dehoogii F41-4 by NMR-Guided Isolation. RSC Advances, 2016, 6(80), 94763-94770.
13. NMR Screening Approach for Discovery of New 6-Methylpyridinone Derivatives from the Marine-Derived Fungus Leptosphaerulina sp. Arabian Journal of Chemistry, 2017, 10(2), 288-294.
14. Methyl Sartortuoate Inhibits Colon Cancer Cell Growth by Inducing Apoptosis and G2/M-Phase Arrest. International Journal of Molecular Sciences, 2015, 16(8), 19401-19418.
15. Exploration of Indole Alkaloids from Marine Fungus Pseudallescheria boydii F44-1 Using an Amino Acid-Directed Strategy. Marine Drugs, 2019, 17(2), 77: 1-9.

其余文章省略。