
徐晓宇
副教授
研究领域:智能药物递送及控释系统,工程化免疫细胞治疗,临床疾病多模式诊疗一体化
联系邮箱: xuxy296@mail.sysu.edu.cn
徐晓宇,博士,bm11222宝马娱乐网站副教授,博导。2021年博士提前毕业于bm11222宝马娱乐网站,获药剂学博士学位。2021-2024年期间在中国科学院深圳先进技术研究院从事博士后研究工作。2024年8月入职bm11222宝马娱乐网站。先后主持国家自然科学基金青年项目、深圳市基础研究面上项目、广东省区域联合基金青年项目、中国博士后科学基金面上一等资助、先进院优秀青年创新基金共5项课题,并参与广东省纳米医药重点实验室、国家重点研发计划子课题等科研项目。迄今相关研究成果共发表SCI论文20余篇,其中以第一作者(含共同)在Advanced Functional Materials、ACS Nano、Nano Today、Biomaterials、Chemical Engineering Journal、Theranostics、Carbohydrate Polymers、ACS Applied Materials & Interfaces、European Journal of Medicinal Chemistry等国际权威学术期刊发表论文10余篇。申请国家发明专利10余项。担任ACS Applied Materials & Interfaces、Journal of Controlled Release、International Journal of Biological Macromolecules、International Journal of Pharmaceutics等药剂学领域期刊审稿人。现担任Exploration杂志青年编委,Pharmaceutics杂志特刊主题“ROS-Mediated Nano Drug Delivery for Antitumor Therapy”客座编辑(欢迎投稿,截稿日期2025.02.28)。
教育与工作经历
2010.09---2014.07, bm11222宝马娱乐网站,药学,理学学士
2014.09---2017.07, bm11222宝马娱乐网站,药剂学,理学硕士
2018.09---2021.07, bm11222宝马娱乐网站,药剂学,理学博士
2021.07---2024.07, 中国科学院深圳先进技术研究院(SIAT),博士后
2024.08------至今, bm11222宝马娱乐网站,药剂学教研室,副教授,博士生导师
研究方向
智能药物递送及控释系统,工程化免疫细胞(CAR-T,NK等)疗法,临床疾病多模式诊疗一体化
方向描述:以临床肿瘤等重大疾病的预防、诊断和治疗所面临的科学难题及迫切需求为导向,融合药学,临床医学,细胞/分子生物学,免疫学,生物医学工程等交叉学科,设计及开发基于生物活性功能元件的智能药物制剂及多模式诊疗一体化系统,以期实现临床重大疾病的精准可控,安全高效的诊断和治疗模式。
科研项目
国家自然科学基金青年项目,82204302,2023.01-2025.12,30万,主持
深圳市基础研究面上项目,JCYJ20220531095815034,2022.10-2025.10,30万,主持
广东省区域联合基金青年项目,2021A1515110884,2021.10-2024.09,10万,主持
中国博士后科学基金第71批面上一等资助,2022M710160,2022.08-2024.07,12万,主持
深圳先进技术研究院优秀青年创新基金,E2G0441001,2022.03-2023.12,10万,主持
代表性论文
- X. Xu, M. Chen, S. Jiang, Z. Pan, C. Zhao, Endoplasmic Reticulum-Targeting Iridium(III) Nanosonosensitizer Amplifies Immunogenic Cell Death for Boosted Tumor Sono-Immunotherapy, Advanced Functional Materials (2024) 2314780. (中科院1区,Top,IF=19.0)
- X. Xu, J. Zheng, N. Liang, X. Zhang, S. Shabiti, Z. Wang, S. Yu, Z. Pan, W. Li, L. Cai, Bioorthogonal/Ultrasound Activated Oncolytic Pyroptosis Amplifies In Situ Tumor Vaccination for Boosting Antitumor Immunity, ACS Nano 18 (2024) 9413-9430. (中科院1区,Top,IF=17.1)
- X. Xu, S. Shabiti, X. Zhang, J. Zheng, N. Liang, Z. Wang, S. Yu, Y. Wang, S. Jiang, Z. Pan, W. Li, L. Cai, Membrane-Anchoring Clickable Iridium(III) Nanosonosensitizer In Situ Evokes PANoptosis for Augmented Tumor Sono-Immunotherapy, Nano Today (2024) 102270. (中科院1区,Top,IF=17.4)
- X. Xu, Z. Zeng, X. Ding, T. Shan, Q. Liu, M. Chen, M. Xia, Y. He, Z. Huang, Y. Huang, C. Zhao, Reactive oxygen species-activatable self-amplifying Watson-Crick base pairing-inspired supramolecular nanoprodrug for tumor-specific therapy, Biomaterials 277 (2021) 121128. (中科院1区,Top,IF=14.0)
- X. Xu#, Z. Zeng#, J. Chen, B. Huang, Z. Guan, Y. Huang, Z. Huang, C. Zhao, Tumor-targeted supramolecular catalytic nanoreactor for synergistic chemo/chemodynamic therapy via oxidative stress amplification and cascaded Fenton reaction, Chemical Engineering Journal 390 (2020) 124628. (中科院1区,Top,IF=15.1)
- X. Xu#, B. Huang#, Z. Zeng, J. Chen, Z. Huang, Z. Guan, M. Chen, Y. Huang, C. Zhao, Broaden sources and reduce expenditure: Tumor-specific transformable oxidative stress nanoamplifier enabling economized photodynamic therapy for reinforced oxidation therapy, Theranostics 10 (2020) 10513-10530. (中科院1区,Top,IF=12.4)
- X. Xu, Z. Zeng, Z. Huang, Y. Sun, Y. Huang, J. Chen, J. Ye, H. Yang, C. Yang, C. Zhao, Near-infrared light-triggered degradable hyaluronic acid hydrogel for on-demand drug release and combined chemo-photodynamic therapy, Carbohydrate Polymers 229 (2020) 115394. (中科院1区,Top,IF=11.2)
- X. Xu, Z. Huang, Z. Huang, X. Zhang, S. He, X. Sun, Y. Shen, M. Yan, C. Zhao, Injectable, NIR/pH-Responsive Nanocomposite Hydrogel as Long-Acting Implant for Chemophotothermal Synergistic Cancer Therapy, ACS Applied Materials & Interfaces 9 (2017) 20361-20375. (中科院2区,Top,IF=9.5)
- R. Guan#, X. Xu#, M. Chen#, H. Hu, H. Ge, S. Wen, S. Zhou, R. Pi, Advances in the studies of roles of Rho/Rho-kinase in diseases and the development of its inhibitors, European Journal of Medicinal Chemistry 70 (2013) 613-622. (中科院2区,Top,IF=6.7)
- Z. Zeng#, Y. Luo#, X. Xu, T. Shan, M. Chen, Z. Huang, Y. Huang, C. Zhao, A mitochondria-targeting ROS-activated nanoprodrug for self-augmented antitumor oxidation therapy, Journal of Controlled Release 359 (2023) 415-427. (中科院1区,Top,IF=10.8)
- X. Sun#, D. Liu#, X. Xu, Y. Shen, Y. Huang, Z. Zeng, M. Xia, C. Zhao, NIR-triggered thermo-responsive biodegradable hydrogel with combination of photothermal and thermodynamic therapy for hypoxic tumor, Asian Journal of Pharmaceutical Sciences 15(6) (2020) 713-727. (中科院1区,IF=10.2)
- Z. Lan, X. Xu, W. Xu, J. Li, Z. Liang, X. Zhang, M. Lei, C. Zhao, Discovery of 3-n-butyl-2,3-dihydro-1H-isoindol-1-one as a potential anti-ischemic stroke agent, Drug Design, Development and Therapy 9 (2015) 3377-91. (中科院2区,IF=4.8)
- 蔡林涛,徐晓宇,李文军,潘正银,郑金玲,梁娜,张旭,沙依拜,王子茜。一种生物正交激活的声敏剂、纳米颗粒及制备方法与应用,中国,CN202311833768.2