姜伊鸣

姜伊鸣博士，bm11222宝马娱乐网站副教授，中山大学逸仙新锐学者。研究方向为药物代谢对肝脏生理和病理的调控作用的相关研究。2008至2018年在bm11222宝马娱乐网站进行本科、硕士及博士学习，2017年受国际交流项目资助赴美国国立卫生研究院访问学习。先后主持国家自然科学基金面上项目、国家自然科学基金青年项目、广东省自然科学基金面上项目、广州市科技计划等项目6项，参与国家重点研发计划等国家级项目9项。研究成果共发表SCI论文30余篇，其中一作/通讯发表在Adv Sci、Hepatology、Br J Pharmacol、Toxicol Sci、Acta Pharmacol Sin等知名学术刊物上。申请国家发明专利9项，已获授权4项；2018年获得中国药理学会药物代谢-刘昌孝人才奖。

2024年招生计划：招药理学硕1名，药物评价专硕1名

教育与工作经历

2008.09-2012.06，bm11222宝马娱乐网站，药学专业，获学士学位

2012.09-2015.06，bm11222宝马娱乐网站，药学硕士专业，获硕士学位

2015.09-2018.06，bm11222宝马娱乐网站，药理学专业，获博士学位

2017.09-2017.12, 美国国立卫生研究院（NIH），访问学习

2018.08-2021.08，bm11222宝马娱乐网站，特聘副研究员

2021.09-至今，bm11222宝马娱乐网站，副教授

学术/社会任职

中国药理学会药物代谢青年委员会委员

广东省药理学会药物代谢委员会委员

广东省药理学会临床药理委员会委员

广东省药理学会药理毒理委员会委员

科研项目

1. 国家自然科学基金-面上项目，82173881，负责人；
2. 国家自然科学基金-青年项目，82003840，负责人；
3. 广州市科技基础与应用基础研究项目，2024A04J9901，负责人
4. 中央高校基本科研业务项目，22qntd4502，负责人
5. 广东省自然科学基金-面上项目，2019A1515010247，负责人；
6. 广州市科技基础与应用基础研究项目，202102020717，负责人。

代表性论文

1. Tingting Zhao#, Guoping Zhong#, Ying Wang, Renjie Cao, Shaofei Song, Yuan Li, Guohui Wan, Haiyan Sun, Min Huang*, Huichang Bi*, Yiming Jiang (姜伊鸣)*. Pregnane X Receptor Activation in Liver Macrophages Protects against Endotoxin-induced Liver Injury. Adv Sci. 2024, e2308771. DOI: 10.1002/advs.202308771.
2. Shaofei Song#, Hong Peng#, Yuan Li, Tingting Zhao, Renjie Cao, Lei Zheng, Min Huang, Yiming Jiang (姜伊鸣)*. Oleanolic acid promotes liver regeneration after partial hepatectomy via regulating pregnane X receptor signaling pathway in mice. Chemico-Biological Interactions. 2024. https://doi.org/10.1016/j.cbi.2024.110970
3. Yiming Jiang# (姜伊鸣), Yanying Zhou#, Shaofei Song, Shicheng Fan, Yue Gao, Yuan Li, Min Huang*, Huichang Bi*. St. John's Wort Exacerbates Acetaminophen-Induced Liver Injury by Activation of PXR and CYP-Mediated Bioactivation. Toxicol Sci. 2022 Oct 27;190(1):54-63.
4. Yiming Jiang (姜伊鸣), Xinpeng Yao, Shicheng Fan, Yue Gao, HuizhenZhang, Min Huang*, Huichang Bi*. Lipidomic profiling reveals triacylglycerol accumulation in the liver during pregnane X receptor activation-induced hepatomegaly. J Pharm Biomed Anal. 2021 Feb 20:195:113851.
5. Yiming Jiang# (姜伊鸣), MinghuaJin#, Jingkao Chen#, Jinwu Yan, PeiqingLiu, Meicun Yao, Weibin Cai, Rongbiao Pi*.Discovery of a novel niacin-lipoic aciddimer N2L attenuating atherosclerosis and dyslipidemia with non-flushing effects. Eur J Pharmacol. 2020 Feb 5;868:172871.
6. Yiming Jiang (姜伊鸣), Dechun Feng, Xiaochao Ma, Shicheng Fan, Yue Gao, Kaili Fu, Ying Wang, Jiahong Sun, Xinpeng Yao, Conghui Liu, Huizhen Zhang,Leqian Xu, Aiming Liu, Frank J. Gonzalez, Yingzi Yang, Bin Gao, Min Huang, Huichang Bi*. Pregnane X Receptor Regulates Liver Size and Liver Cell Fate via Yes-associated Protein Activation. Hepatology. 2019 Jan;69(1):343-358.
7. Hang Zeng#, Yiming Jiang# (姜伊鸣，共同一作),Pan Chen, Xiaomei Fan, Dongshun Li, Aiming Liu, Xiaochao Ma, Wen Xie, Peiqing Liu, Frank J Gonzalez, Min Huang and Huichang Bi*, Schisandrol B protects against cholestatic liver injury through pregnane X receptors. Br J Pharmacol. 2017 Apr;174(8):672-688.
8. Huizhen Zhang#, Yiming Jiang# (姜伊鸣，共同一作), Jingjing Wu, Chuanqi Zheng, Xiaorong Ran, Dongshun Li, Min Huang, Huichang Bi*.Metabolic mapping of Schisandra sphenanthera extract and its active lignans using a metabolomic approach based on ultra high performance liquid chromatography with high-resolution mass spectrometry. J Sep Sci. 2017 Jan;40(2):574-586.
9. Yiming Jiang# (姜伊鸣), Ying Wang#, Huasen Tan, Tao Yu, Xiaomei Fan, Pan Chen, Hang Zeng, Min Huang*, Huichang Bi*. Schisandrol B protects against acetaminophen-induced acute hepatotoxicity in mice via activation of the NRF2/ARE signaling pathway. Acta Pharmacol Sin. 2016 Mar;37(3):382-9.
10. Yiming Jiang# (姜伊鸣), Xiaomei Fan#, Ying Wang , Huasen Tan, Pan Chen, Hang Zeng , Min Huang*,Huichang Bi*. Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation. Chem Biol Interact. 2015 25;231:83-9.
11. Ying Wang#, Yiming Jiang# (姜伊鸣，共同一作), Xiaomei Fan, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen, Min Huang, Huichang Bi*. Hepato-protective effect of resveratrol against acetaminophen-induced liver injury is associated with inhibition of CYP-mediated bioactivation and regulation of SIRT1-p53 signaling pathways. Toxicol Lett. 2015 16;236(2):82-9.
12. Yiming Jiang# (姜伊鸣), Xiaomei Fan#, Ying Wang, Pan Chen, Hang Zeng,Huasen Tan, Frank J. Gonzalez, Min Huang* and Huichang Bi*. Schisandrol B protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of liver regeneration. Toxicol Sci. 2015 Jan;143(1):107-15.

Xiaomei Fan#, Yiming Jiang# (姜伊鸣，共同一作), Ying Wang, Huasen Tan, Hang Zeng, Yongtao Wang, Pan Chen,Aijuan Qu, Frank J. Gonzalez, Min Huang, and Huichang Bi*. Wuzhi tablet (Schisandra Sphenanthera extract) protects against acetaminophen-induced hepatotoxicity by inhibition of CYP-mediated bioactivation and regulation of NRF2-ARE and p53/p21 pathways. Drug Metab Dispos. 2014 Dec;42(12):1982-90.