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黄佳国

教授

研究领域：生物医学技术（包括分子探针、诊断试剂及体外检测设备/技术）的开发及其在重大疾病中的诊断，监测和治疗应用。

联系邮箱： huangjg36@mail.sysu.edu.cn

个人主页： https://www.x-mol.com/groups/huanglab-online

黄佳国，教授，博士生导师，入选国家重大人才计划青年项目，中山大学‘百人计划’中青年杰出人才项目、‘欧盟玛丽居里学者’及广东省珠江人才计划引进创新团队核心成员。博士毕业于德国海德堡大学，随后在德国海德堡大学及新加坡南洋理工大学从事博士后研究。2021年9月加入bm11222宝马娱乐网站。主持国家自然科学基金和广东省自然科学基金等多项科研项目。入选全球前2%顶尖科学家榜单。迄今共发表SCI论文70余篇，申请发明专利10项。其中于第一及通讯作者身份发表论文30多篇，包括Nature Materials (2019, 2022)，Nature Reviews Chemistry (2021)，Angew. Chem. Int. Ed.，Adv. Mater., ACS nano, Adv. Func. Mater., Chemical science等，成果多次被Nat. Rev. Nephrol、Nat. Mater. 等期刊媒体作为亮点进行评述。

课题组网址/Group website：https://www.x-mol.com/groups/huanglab-online

ORCID: https://orcid.org/0000-0003-4012-4406

Google Scholar Profile: https://scholar.google.de/citations?user=ElAPm6sAAAAJ&hl=zh-CN

招生招聘信息

1. 课题组2024年招收硕士和博士若干，欢迎咨询报考。

2. 课题组长期招聘具有药学，化学，分子影像学，分子生物学，生物材料学，基础医学背景，对疾病诊疗领域感兴趣的博士后和专职研究员，待遇从优。

研究方向

生物医学技术（包括分子探针、诊断试剂及体外检测设备/技术）的开发及其在重大疾病中的诊断，监测和治疗应用。

科研项目

国家重大人才计划-青年项目

国家重点研发计划-青年科学家项目

国家自然科学基金-青年项目

国家自然科学基金-面上项目

广东省‘珠江人才计划’创新创业团队

广东自然科学基金面上项目

广州市重点领域研发计划-健康医疗重大科技专项

中山大学百人计划‘中青年杰出人才项目’

中央高校基本科研业务费-青年拔尖科研人才培育项目

教育背景及工作经历

2017. 06–2021.05  新加坡南洋理工大学   博士后研究员

2016. 06–2017.05  德国海德堡大学       博士后研究员

2012. 10– 2016. 05  德国海德堡大学      博士

2009. 09 - 2012. 07  中南大学           理学硕士

2005. 09 - 2009. 07  南昌大学           理学学士

科研成果：代表性论著                                        

  1. Weiping Xu#, Shujuan Yi#, Jie Liu, Yuyan Jiang, Jiaguo Huang*. Nitrile-aminothiol bioorthogonal near-infrared fluorogenic probes for ultrasensitive in vivo imaging. Nature Communications. 2024, DOI : 10.1038/s41467-024-55452-y.
  2. Mengya Yu#, Lijuan Zhu#, Guoqi Dong, Jianjiao Chen, Bankang Ruan, Yi Liu, Shujuan Yi, Zhenqi Meng, Guanjian Chen, Weiping Xu*, Jiaguo Huang*, Fanghai Han*. Spatiotemporal Mapping of Lymphatic Metastases in Gastric Cancer Using Tumor-trackable and Enzyme-activatable Near-infrared Fluorescent Nanoprobes. ACS nano. 2024, DOI : 10.1021/acsnano.4c12915.
  3. Ya Zhou#, Weiping Xu#, Bankang Ruan, Lijuan Zhu, Yuyan Jiang, Hui Cai, Jiaguo Huang*. Molecular Imaging of Renin Activity using Fluorogenic Nanoprobes for Precise Antihypertensive Therapy. Angew. Chem. Int. Ed. 2024, DOI: 10.1002/anie.202416002. (IF= 16.82)
  4. Yi Liu#, Shanchao Diao#, Bankang Ruan#, Ya Zhou#, Mengya Yu, Guoqi Dong, Weiping Xu, Lulu Ning, Wen Zhou, Yuyan Jiang, Chen Xie*, Quli Fan*, Jiaguo Huang*. Molecular Engineering of Activatable NIR-II Hemicyanine Reporters for Early Diagnosis and Prognostic Assessment of Inflammatory Bowel Disease. ACS nano 2024, 18(11), 8437-8451. (IF= 17.1)
  5. Ya Zhou#, Lijuan Zhu#, Biaoxiang Liu, Weiping Xu, Xingyue Yang, Yi Liu, Bankang Ruan, Shujuan Yi, Baoshuai Liang, Guoqi Dong, Jiaguo Huang*. Tailored Zwitterionic Hemicyanine Reporters for Early Diagnosis and Prognostic Assessment of Acute Renal Failure.Angew. Chem. Int. Ed. 2023, 62, e202315457. (IF= 16.82)
  6. Bankang Ruan, Mengya Yu, Ya Zhou, Weiping Xu, Yi Liu, Biaoxiang Liu, Lijuan Zhu, Shujuan Yi, Yuyan Jiang, Jiaguo Huang*. Size-transformable superoxide-triggered nanoreporters for crosstalk-free dual fluorescence/chemiluminescence imaging and urinalysis in living mice. Angew Chem Int Edit. 2023, e202305812. (IF=16.82)
  7. Jiaguo Huang, Xiaona Chen, Yuyan Jiang, Chi Zhang, Shasha He, Hangxiang Wang, Kanyi Pu. Renal clearable polyfluorophore nanosensors for early diagnosis of cancer and allograft rejection. Nature Materials. 2022, 21, 598-607. (IF= 47.56)
  8. Jiaguo Huang, Jingchao Li, Yan Lyu, Qingqing Miao, and Kanyi Pu. Molecular optical imaging probes for early diagnosis of drug-induced acute kidney injury. Nature Materials. 2019, 18, 1133-1143. (IF= 47.56)
  9. Luling Wu#, Jiaguo Huang#, Kanyi Pu, Tony D. James. Dual-locked spectroscopic probes for sensing and therapy. Nature Reviews Chemistry, 2021, 5, 406-421. (IF= 34.57，共同一作)
  10. Jiaguo Huang, Shiyun Xian, Yi Liu, Xiaona Chen, Kanyi Pu, Hangxiang Wang. A Renal clearable activatable polymeric nanoprobe for early detection of hepatic ischemia-reperfusion injury. Advanced Materials. 2022, 2201357. (IF= 32.08)
  11. Jiaguo Huang, Yuyan Jiang, Jingchao Li, Shasha He, Jingsheng Huang, Kanyi Pu. A renal-clearable macromolecular reporter for near-infrared fluorescence imaging of bladder cancer. Angew Chem Int Ed. 2020, 59, 4415-4420. (IF=16.82)
  12. Jiaguo Huang, Chen Xie, Xiaodong Zhang, Yuyan Jiang, Jingchao Li, Quli Fan, Kanyi Pu. Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction. Angew Chem Int Ed. 2019, 58, 15120-15127. (IF=16.82)
  13. Jiaguo Huang, Yan Lyu, Jingchao Li, Penghui Cheng, Yuyan Jiang, Kanyi Pu. A renal-clearable duplex optical reporter for real-time imaging of contrast-induced acute kidney injury. Angew Chem Int Ed. 2019, 58, 17796-17804. (IF=16.82)
  14. Jiaguo Huang, Kanyi Pu. Activatable molecular probes for second near-infrared fluorescence, chemiluminescence, and photoacoustic Imaging. Angew Chem Int Ed. 2020, 59, 11717-11731. (IF=16.82)
  15. Jingsheng Huang#, Jiaguo Huang#, Penghui Cheng, Yuyan Jiang, Kanyi Pu. Near-infrared chemiluminescent reporters for in vivo imaging of reactive oxygen and nitrogen species in kidneys. Advanced Functional Materials, 2020, 30, 2003628. (IF=18.80，共同一作)
  16. Jiaguo Huang, Kanyi Pu. Near-infrared fluorescent molecular probes for imaging and diagnosis of nephro-urological diseases. Chemical Science, 2021, 12, 3379-3392. (IF= 9.83)
  17. Jiaguo Huang, Stefanie Weinfurter, Cristina Daniele, Rossana Perciaccante, Rodeghiero Federica, Leopoldo Della Ciana, Johannes Pilla and Norbert Gretz. Zwitterionic near infrared fluorescent agents for noninvasive real-time transcutaneous assessment of kidney function. Chemical Science, 2017, 8, 2652-2660. (IF= 9.83)

部分发明专利  

  1. 黄佳国，刘彪翔，柳乂。一种生物标志物响应型荧光示踪剂及其制备方法和应用 (202111482551.2)
  2. 黄佳国、柳乂、阮班康、周娅。一种近红外二区荧光化合物及其制备方法与应用 （202211727312.3）
  3. Kanyi Pu, Jiaguo Huang. Molecular renal reporters for real-time optical imaging of drug-induced acute kidney injury. Application number: 10201900965U.
  4. Della Ciana Leopoldo, Gretz Norbert, Perciaccante Rossana, Rodeghiero Federica, Geraci Stefania, Huang Jiaguo, Herrera Pérez Zeneida, Pill Johannes, Weinfurter Stefanie. Novel tricarbocyanine-cyclodextrin(s) conjugates and uses thereof. Application number: US20150328342A1.
  5. Gretz Norbert, Rudolf Rüdiger, Weinfurter Stefanie, Brenna Cinzia, Huang Jiaguo, Khan Arif ul Maula. Means and Methods for Visualization of Tissue Structures. Application number: PCT/EP2017/081034.
  6. Wenbin Zeng, Zhiguo Liu, Jiaguo Huang. Dansyl molecular probe and synthetic method and application thereof. Application number: CN201010183549