药学前沿大讲堂第101讲-Recent developments in PBPK models on drug absorption and disposition
Recent developments in PBPK models on drug absorption and disposition
题目：Recent developments in PBPK models on drug absorption and disposition
报告人：K. Sandy Pang, PhD, Professor
Department of Pharmaceutical Sciences, University of Toronto.
主持人：黄民 教授
bm11222宝马娱乐网站
时间：2011年10月10日下午3：00
地点：中山大学东校区bm11222宝马娱乐网站125会议室
主讲人简介：
Dr. Pang, received her B.Sc. (Pharmacy) from the University of Toronto and Ph.D. (Pharm Chem) in the area of pharmacokinetics with Dr. Malcolm Rowland from the University of California. She received further postdoctoral training as a Fogarty fellow at the National Institutes of Health, Bethesda, MD, under the sponsorship of Dr. James R. Gillette. She is now Professor of Pharmacy and Pharmacology at the Faculties of Pharmacy and Medicine at the University of Toronto.Her research interest is to apply pharmacokinetic theory to study drug transport and metabolism.Her laboratory has developed physiologically-based models. The models include transporters, enzymes and their heterogeneity, as well as binding to explain route-dependent metabolism of drugs during intestinal absorption, and other models of drug clearances for the liver and kidney. The concepts she has developed have provided a solid basis towards the understanding of metabolism, transport, and removal of drugs and metabolites in eliminating organs.
Her recent interests include examination of the role of the vitamin D receptor (VDR) on the regulation of transporter and enzyme target genes in the Caco-2 and LS-180 cell monolayers, human hepatocytes, and in animals, including gene knock- out mice.
She serves as the Editor of Biopharmaceutics and Drug Disposition, and Editorial Review Board Member of Journals: American Journal of Physiology, Drug Metabolism and Disposition, the Journal of Pharmacology and Experimental Therapeutics, and the Journal of Pharmacokinetics and Pharmacodynamics, etc.
She has published more than 200 papers in journals such as Molecular Pharmaceutics, Drug Metabolism and Disposition, Journal of Pharmacology and Experimental Therapeutics, Journal of Pharmaceutical Sciences, Journal of Pharmacokinetics and Pharmacodynamics, and Biopharmaceutics and Drug Disposition, etc.
She was the recipient of the NIH Research Career Development Award, Faculty Development award from the Medical Research Council of Canada, the McNeil Award from the Faculties of Pharmacies in Canada, and the Research Achievement Award in Pharmacokinetics, Pharmacodynamics and Drug Metabolism from the American Association of Pharmaceutical Scientists (AAPS).
