药学前沿大讲堂第443讲

题  目: Adventures of Nucleic Acids in Molecular Crowding World

报告人: Prfo. Naoki Sugimoto，Konan University

主持人: 谭嘉恒 教授，bm11222宝马娱乐网站

时  间: 2019年3月23日（周六）9:30-11:00

地  点: 中山大学东校园bm11222宝马娱乐网站112会议室

报告人简介:

Non-canonical structures of nucleic acids such as a triplex and a quadruplex are stabilized under conditions that mimic the crowded cellular conditions and have been detected in cells. It is possible that the non-canonical structures act as “functional codes” triggered by different molecular environments that regulate gene expression epigenetically. As sequences capable of forming the non-canonical structures are found in telomeres and promoter regions of known oncogenes, alterations of the non-canonical structures could play important roles in the progression of cancer and in other diseases.

In this lecture, Prof. Sugimoto will talk and discuss how the structures, topologies, and functions of nucleic acids differ under various conditions such as highly crowded environments and affect the gene expression.

N. Sugimoto and colleagues, Anal. Chem. 2019, in press, J. Am. Chem. Soc. 2018,140, 5774-5783, J. Am. Chem. Soc. 2018,140, 642-651, Angew. Chem. Int. Ed. 2018, 57, 15723-15727, Angew. Chem. Int. Ed. 2018, 57, 6868-6872, Nature Struct. Mol. Bio. 2018, 25, 279-288, Nucleic Acids Res., 2018, 46, 4301–4315, Proc. Natl. Acad. Sci. U. S. A. 2017, 114, 9605-9610, J. Am. Chem. Soc. 2017, 139, 7768-7779, Nucleic Acids Res. 2017, 45, 7021-7030, Nucleic Acids Res. 2017, 45, 461-469, and so on.