bm11222宝马娱乐网站十周年院庆系列活动­之药学前沿大讲堂第124讲

bm11222宝马娱乐网站十周年院庆系列活动­————

药学前沿大讲堂第124讲

题  目：Structure-based Antiviral Drug Discovery: Case Studies of Anti-Influenza, HIV and Hepatitis Agents

报告人：Xiaowu Chen（陈小五）Ph.D.

               Sr. Scientist, molecular modeling and structure-based drug discovery, Gilead Sciences, Foster City, California

主持人：徐 峻 教授    bm11222宝马娱乐网站

时  间：2012年8月21日（周二） 下午2:30

地  点：中山大学东校区bm11222宝马娱乐网站  125讲学厅

报告内容：

Viral diseases pose significant threats to humanity.  Influenza, HIV, and hepatitis infections account for majority of deadly viral diseases.  So far Tamiflu is the only oral anti-influenza drug with broad spectrum activity.  During the discovery of Tamiflu at Gilead, an unusual hydrophobic-polar π interaction between charged amino acids of influenza neuraminidase and hydrophobic moiety of Tamiflu has been identified, such interaction is crucial for Tamiflu’s potency. This observation is against conventional thinking in terms of molecular interactions and may provide an additional dimension in future molecular interaction and drug design.  Hepatitis C NS3 protease is another interesting viral target that has attracted significant effort from both academia and pharmaceutical industry.  A scaffold-dependent structure-activity relationship (SAR)  have been predicted by molecular modeling and validated by experimental results. Details of these discoveries will be discussed.

报告人介绍：

    陈小五博士于1984年在厦门大学化学系取得物理化学专业的学士学位，并于1993年在美国宾夕法尼亚州立大学获得生物物理学/物理化学专业的博士学位。于1993-1997年期间在美国加利福尼亚大学进行博士后研究工作。其后，于1997年至今在Gilead Sciences 公司进行分子模拟和基于结构的药物设计研究工作。 陈博士与合作者已获得美国授权专利11项。此外，陈博士还多次被邀请在重大学术会议上做口头报告，并在国际重要期刊上发表论文37余篇。