bm11222宝马娱乐网站第二届教授沙龙暨药学前沿大讲堂第57讲

G Protein signaling and proteoglycan synthesis in human vascular smooth muscle cells.

发布人：高级管理员 发布日期：2013-02-27
主题
G Protein signaling and proteoglycan synthesis in human vascular smooth muscle cells.
活动时间
-
活动地址
中山大学东校区药学楼125讲学厅
主讲人
Prof. Peter J. Little, B. Pharm., Ph. D., AM
主持人
郑文华 教授
主　题：G Protein signaling and proteoglycan synthesis in human vascular smooth muscle cells.

 

报告人：Prof. Peter J. Little, B. Pharm., Ph. D., AM

 

Head, Diabetes and Cell Biology Laboratory, BakerIDI Heart and Diabetes Institute, Melbourne, Australia.

 

主持人：郑文华 教授  bm11222宝马娱乐网站

 

时　间：2010年4月29日上午10：30～12：00

 

地　点：中山大学东校区药学楼125讲学厅

 

摘　要：GPCR are the most important receptors in cardiovascular physiology and pathology and the target of many cardiovascular drugs. In our investigation of the agents regulating proteoglycan synthesis in vascular smooth muscle cells (VSMC) we have investigated various GPCR agonists. Cultured VSMCS respond poorly to angiotensin II so we have concentrated on thrombin and endothelin‑1. Thrombin and endothelin‑1 stimulate proteoglycan synthesis in VSMCs and we have described the relevant signaling pathways. In very recent work we have discovered a new GPCR signaling pathway whose impact almost certainly extends beyond proteoglycan synthesis and initial data will be presented on this novel pathway.

 

 

Peter教授简介：

 

Peter J Little教授是世界知名的心脏和糖尿病专家，就职于国际知名的科研机构——澳大利亚墨尔本Baker IDI心脏和糖尿病研究所，现任澳大利亚生物脉管学会会长和Diabetes and Cell Biology实验室主任，是澳大利亚心脏科学和糖尿病学科的学科带头人，澳大利亚Monash University荣誉教授及Royal Melbourne Institute of Technology University兼职教授，他致力于促进心脏科学心血管药物研究等方面的发展,为此作出了重要贡献并在澳大利亚及世界上获得多种奖项。现担任“nutrition”等多家国际知名杂志编辑和审稿人，撰写多篇高影响因子的论文发表于circulation， J Biol Chem， Cell Mol Life Sci， J Cell Mol Med， Atherosclerosis， Curr Opin Lipidol，等高水平杂志上。