药学前沿大讲堂第55讲-Discovery and Mechanistic Studies of Novel Angiogenesis Inhibitors from the Johns Hopkins Drug Library

报告题目：Discovery and Mechanistic Studies of Novel Angiogenesis Inhibitors from the Johns Hopkins Drug Library

主 讲 人：刘钧  教授  

美国霍普金斯大学医学院药理和分子科学系、肿瘤学系

主 持 人： 黄民  教授  bm11222宝马娱乐网站院长

讲座时间：2010年4月6日　星期二 下午15:00

讲座地点：中山大学东校区药学楼125讲学厅

Abstract：
Contemporary drug discovery and development is a costly and time-consuming process.  It has been estimated that it now takes about a decade and costs close to one billion US dollars to develop a new drug from start to finish.  To speed up the drug development process, we have built a library of mostly clinical drugs, called the Johns Hopkins Drug Library (JHDL).  We have screened JHDL in multiple assays including endothelial cell proliferation in search for inhibitors of angiogenesis. We have found several known drugs with previously unappreciated anti-angiogenic activity.  Subsequent mechanistic studies have led to new insights on the functions of the targets of the inhibitors.  Preclinical evaluations revealed that these inhibitors are efficacious in blocking angiogenesis and tumor growth in vivo, paving the way for these inhibitors to enter human clinical trials.

刘钧教授简介：

刘钧教授1983年毕业于南京大学，1986年于美国俄亥俄洲立大学获硕士学位，1990年于美国麻省理工学院获博士学位，1992年于美国哈佛大学做博士后研究。之后于美国麻省理工学院任助理教授、副教授。从2001年起供职于美国霍普金斯大学医学院，历任神经科学系、药理和分子科学系及肿瘤学系教授。刘钧教授具有化学和生物学的双重学术背景，是目前国际范围内新兴的化学生物学领域中最优秀的年轻教授之一。

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2010年4月1日